Veteriner Hekimlikte İmmünokontrasepsiyon

Year 2022, Volume: 11 Issue: 2, 263 - 268, 30.12.2022

Anıl Gürkan Aksu , Serhan Serhat Ay

https://doi.org/10.31196/huvfd.1153097

Abstract

Hayvan popülasyonundaki kontrolsüz artış üremenin denetlenmesi konusunu daha da önemli hale getirmiştir. Tüm dünyada kontrasepsiyon amacıyla halen kullanılmakta olan cerrahi ve hormonal yöntemlerin birçok dezavantajı bulunmaktadır. İmmünokontrasepsiyon bu dezavantajları ortadan kaldırmak amacıyla yeni bir kontrasepsiyon yöntemi olarak düşünülmüştür. Görevi çeşitli etkenlere karşı vücudu korumak olan immün sistemin fizyolojik tolerans etkisi gebeliğin devam etmesini sağlamaktadır. İmmünokontrasepsiyon ile immün sistemin bu etkisi tersine çevrilerek gebelik ile sonuçlanan reprodüktif süreci bozmaktadır. Farklı deyişle immün sistemin vücudun kendi reprodüktif sürecinde belli aşamalara/dokulara saldırması ile sağlanmaktadır. Bunun için bir antijen-antikor kompleksinin oluşturulması gereklidir. 1970’li yıllardan bu yana çalışılmakta olan immünokontraseptiyon alanında hali hazırda zona pelusida (ZP), gonadotropin salgılatıcı hormon (GnRH) ve lüteinleştirici hormon (LH) reseptörlerine karşı aşılamalar geliştirilmiştir. Sunulan derleme immünokontrasepsiyon ve günümüzde kullanılan aşılar hakkındaki bilgilerin güncellenmesi amacıyla hazırlanmıştır.

Keywords

GnRH aşısı, Üremenin denetlenmesi, İmmünokontrasepsiyon, ZP aşısı

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