Diabetes Mellitus'ta Düzenli Koşu Bandı Egzersizinin Bazı Kan Parametreleri Üzerindeki Etkisi

Year 2023, Volume: 12 Issue: 1, 112 - 117, 22.06.2023

Canan Ceylan , Mehmet Özsan , Nurcan Dönmez

https://doi.org/10.31196/huvfd.1281402

Abstract

Bu çalışma, deneysel diyabet modeli oluşturulan sıçanlarda düzenli koşu bandı egzersizinin bazı kan parametreleri üzerindeki etkilerini belirlemeyi amaçlamaktadır. Çalışmada 36 adet Wistar Albino rat Kontrol (K), Egzersiz (E), Diyabet (D) ve Diyabet+Egzersiz (DE) olmak üzere dört gruba ayrıldı. D ve DE gruplarına diyabet modeli oluşturmak için tek doz 60 mg/kg STZ solüsyonu intraperitoneal (i.p) olarak enjekte edildi. Diyabet indüksiyonu sonrası, E ve DE gruplarına dört hafta boyunca, 20 m/dk hızda ve günlük 45 dk. koşu egzersizi yaptırıldı. Elde edilen verilere göre, K grubuna göre D grubunda lipid profil (TK, LDL, TG) seviyeleri ile karaciğer enzim (ALT, AST) düzeyleri önemli ölçüde artış gösterirken, HDL ve TP düzeylerinin azaldığı tespit edildi. Ancak DE grubunda HDL ve TP dışındaki parametrelerde bir düşüş gözlendi. Yine K grubuna oranla D grubunda mineral ve vitamin (Vit D, kalsiyum, magnezyum ve çinko) seviyelerinin azaldığı gözlenirken, DE grubunda bu değerlerin artma eğiliminde olduğu belirlendi. Sonuç olarak, deneysel diyabetli sıçanlarda dört haftalık düzenli egzersiz programının lipoprotein seviyeleri, karaciğer enzim belirteçleri ve mikro besin seviyeleri üzerinde terapötik, önleyici ve koruyucu bir etkiye sahip olduğunu göstermektedir.

Keywords

diabetes mellitus, egzersiz, lipid profili, karaciğer enzimleri, mikrobesinler

Supporting Institution

Selçuk Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Project Number

21212026

The Effects of Regular Treadmill Exercise on Some Blood Parameters in Diabetes Mellitus

Abstract

This study aims to determine the effects of regular treadmill exercise on some blood parameters in rats with an experimental diabetes model. In the study, 36 Wistar Albino rats were divided into four groups Control (C), Exercise (E), Diabetes (D), and Diabetes+Exercise (DE). A single dose of 60 mg/kg STZ solution was injected intraperitoneally (i.p) into the D and DE groups to create a diabetes model. After diabetes induction, E and DE groups were given running exercises at 20 m/min and 45 minutes daily for four weeks. According to the data obtained, while lipid profile (TC, LDL, TG) and liver enzyme (ALT, AST) levels increased significantly in group D compared to group C, HDL and TP levels were found to decrease. However, a decrease was observed in parameters other than HDL and TP in the DE group. It was also observed that the mineral and vitamin (Vit D, Ca, Mg, and Zn) levels decreased in the D group compared to the C group, while these values tended to increase in the DE group. As a result, the experiment shows that a four week regular exercise program in rats with diabetes has a therapeutic, preventive, and protective effect on lipoprotein levels, liver enzyme markers, and micronutrient levels.

Keywords

Diabetes Mellitus, Exercise, Lipid profile, Liver enzymes, Micronutrients

Project Number

21212026

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