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Kronik Efüzyonlu Kronik Süpüratif Otitis Mediada Trombosit-Lenfosit ve Nötrofil-Lenfosit Oranı Henüz Kullanılabilir mi?

Year 2021, Volume: 7 Issue: 2, 15 - 28, 30.08.2021

Abstract

Amaç: Nötrofil Lenfosit Oranı (NLO) ve Trombosit Lenfosit Oranı (PLR) testleri, tüm hekimler tarafından hesaplanabilen ucuz testlerdir. Bu çalışmanın amacı kronik efüzyonlu süpüratif otitis media tanılı hastalarda NLO ve PLO arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem: Bu çalışmaya Ağustos 2015 ile Ağustos 2018 tarihleri arasında kronik süpüratif otitis media tanısı almış hastalar dahil edildi. Bu hastaların hemogram parametreleri hastane otomasyon sisteminden alınarak retrospektif olarak değerlendirildi. Her hasta için NLO ve PLO değerleri, nötrofili lenfosit ile, trombositi lenfosit sayılarıyla bölünerek hesaplandı. Demografik olarak yaş, cinsiyet, klinik tanı ve laboratuvar parametreleri değerlendirildi. Kontrol grubu, vaka grubundaki her hasta için kronik efüzyonlu kronik süpüratif orta kulak iltihabı tanısı olmayan bir hastadan oluştu.
Bulgular: Yapılan analiz sonucunda; CRP, ESR, WBC, MPV, PLR, NLR değerleri trombosit sayısı dışında kronik otitis media grubunda istatistiksel olarak anlamlı yüksek bulundu (p <0.05), ancak ROC analizinde bu değerler anlamlı bulunmadı.
Sonuç: Literatürde kronik otitis media hastalarında NLO ve PLO ile ilgili sınırlı sayıda çalışma vardır ve bu çalışmalarda bu testlerin henüz kullanılabileceğine dair yeterli kanıt yoktur. Standardizasyonu sağlamak ve bu NLO ve PLO oranlarının klinik önemini araştırmak için daha yüksek hasta sayılarına sahip randomize kontrollü çalışmalara ihtiyaç vardır.

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References

  • 1. Paksoy M, Aydın S, Hardal Ü, Çelebi Ö, Eken M. Kronik Otitis Mediada Kemik Zincir, Kulak Zarı Perforasyonları ve işitme Kayıpları ile ilişkisi, Otoscope. 2005; 2: 51 -57.
  • 2. Balta S, Demirkol S, Unlu M, Arslan Z, Celik T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer 2013;109(12):3125-26.
  • 3. Djordjevic D, Rondovic G, Surbatovic M, Stanojevic I, Udovicic I, Andjelic T, et al. Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia? Mediators Inflamm. 2018;2018:3758068. doi: 10.1155/2018/3758068.
  • 4. Buettner S, Spolverato G, Kimbrough CW, Alexandrescu S, Marques HP, Lamelas J, et al. The impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio among patients with intrahepatic cholangio carcinoma. Surgery. 2018;164(3):411-418. doi: 10.1016/j.surg.2018.05.002.
  • 5. Zhang JY, Ge P, Zhang PY, Zhao M, Ren L. Role of Neutrophil to Lymphocyte Ratio or Platelet to Lymphocyte Ratio in Prediction of Bone Metastasis of Prostate Cancer. Clin Lab. 2019;65(5). doi: 10.7754/Clin.Lab.2018.181040.

Is Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratio Valid in Chronic Suppurative Otitis Media with Chronic Effusion Yet?

Year 2021, Volume: 7 Issue: 2, 15 - 28, 30.08.2021

Abstract

Aim: Neutrophil to lymphocyte ratio (NLR) and Platelet-lymphocyte ratio (PLR) tests are inexpensive tests that can be calculated by all physicians. The aim of this study was to investigate the relationship between NLR and PLR in patients with chronic suppurative otitis media with chronic effusion.
Materials and Methods: In this study, patients diagnosed with chronic suppurative otitis media between August 2015 and August 2018 were included. Hemogram parameters of these patients were obtained from hospital system and evaluated retrospectively. The NLR and PLR values for each patient calculated as dividing neutrophil by lymphocyte, platelet by lymphocyte counts respectively. Demographically, age, gender, clinical diagnosis and laboratory parameters were evaluated. The control group consisted of one patient without a diagnosis of chronic suppurative otitis media with chronic effusion for each patient in the case group.
Results: As a result of the analysis it was found that; CRP, ESR, WBC, MPV, PLR, NLR values were statistically significantly higher in the chronic otitis media group except platelet count (p <0.05), but in ROC analysis these values were not found to be significant.
Conclusion: There are a limited number of studies in the literature on NLR and PLR for chronic otitis media patients, and there is not enough evidence in these studies that these tests can be used yet. Randomized controlled studies with higher patient numbers are needed to ensure standardization and to investigate the clinical significance of these NLR and PLR ratios.

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References

  • 1. Paksoy M, Aydın S, Hardal Ü, Çelebi Ö, Eken M. Kronik Otitis Mediada Kemik Zincir, Kulak Zarı Perforasyonları ve işitme Kayıpları ile ilişkisi, Otoscope. 2005; 2: 51 -57.
  • 2. Balta S, Demirkol S, Unlu M, Arslan Z, Celik T. Neutrophil to lymphocyte ratio may be predict of mortality in all conditions. Br J Cancer 2013;109(12):3125-26.
  • 3. Djordjevic D, Rondovic G, Surbatovic M, Stanojevic I, Udovicic I, Andjelic T, et al. Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Mean Platelet Volume-to-Platelet Count Ratio as Biomarkers in Critically Ill and Injured Patients: Which Ratio to Choose to Predict Outcome and Nature of Bacteremia? Mediators Inflamm. 2018;2018:3758068. doi: 10.1155/2018/3758068.
  • 4. Buettner S, Spolverato G, Kimbrough CW, Alexandrescu S, Marques HP, Lamelas J, et al. The impact of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio among patients with intrahepatic cholangio carcinoma. Surgery. 2018;164(3):411-418. doi: 10.1016/j.surg.2018.05.002.
  • 5. Zhang JY, Ge P, Zhang PY, Zhao M, Ren L. Role of Neutrophil to Lymphocyte Ratio or Platelet to Lymphocyte Ratio in Prediction of Bone Metastasis of Prostate Cancer. Clin Lab. 2019;65(5). doi: 10.7754/Clin.Lab.2018.181040.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Sevil Alkan Çeviker 0000-0003-1944-2477

Dursun Mehmet Mehel 0000-0002-5613-3393

Doğukan Özdemir 0000-0003-2008-163X

Abdulkadir Özgür 0000-0002-6155-5988

Özgür Günal 0000-0002-7744-4123

Süleyman Klıç 0000-0002-0238-8008

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Publication Date August 30, 2021
Published in Issue Year 2021 Volume: 7 Issue: 2

Cite

APA Alkan Çeviker, S., Mehel, D. M., Özdemir, D., Özgür, A., et al. (2021). Kronik Efüzyonlu Kronik Süpüratif Otitis Mediada Trombosit-Lenfosit ve Nötrofil-Lenfosit Oranı Henüz Kullanılabilir mi?. International Anatolia Academic Online Journal Health Sciences, 7(2), 15-28.

International Anatolia Academic Online Journal Health Sciences