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EVALUATION OF HYSTEROSCOPIC AND PATHOLOGICAL FINDINGS IN WOMEN WITH ABNORMAL UTERINE BLEEDING

Year 2024, Volume: 10 Issue: 1, 277 - 288, 15.05.2024

Abstract

Introduction: Although abnormal uterine bleeding (AUB) is generally a symptom of benign pathologies. It may also be the most common symptom of endometrial hyperplasia (EH) or cancer. Hysteroscopy (H/S) has great diagnostic accuracy because it allows direct visualization of these pathologies. In our study, we aimed to evaluate the hysteroscopic findings and histopathological results of women with abnormal uterine bleeding who underwent hysteroscopy and biopsy. Materials and Methods: From our study, 2440 patients who were admitted to our hospital between January 2018-2023 and were diagnosed with AUB were evaluated retrospectively. Demographic characteristics of the patients were obtained from the hospital database. H/S were preferably performed in the early follicular phase of the menstrual cycle when there was no or very little bleeding. Results: When the findings obtained before confirming the histopathological diagnosis in patients who underwent hysteroscopy because of AUB were evaluated, no intrauterine pathology was observed in 1320 (54%) patients. Endometrial polyp was detected in 890 (36.4%) patients in the study group and was noted as the most frequently reported hysteroscopic finding. Leiomyoma in 115 (5.1%) patients, EH in 70(2.8%) patients, intrauterine device (IUD) loss in 25 (1%) patients, intrauterine adhesion in 15 (0.6%) patients, and Endometrial Cancer was detected in 5 (%0.2) patients. When the histopathological results were evaluated in patients who underwent hysteroscopy because of AUB, no intrauterine pathology was observed in 1390 (56.9%) patients. Endometrial polyp was detected in 830 (34%) patients and was noted as the most frequently reported histopathological finding. In the study group, 110 (4.5%) patients had leiomyoma, 65 (2.6%) had EH, 25 (1%) had IUD loss, 15 (0.6%) had intrauterine adhesion, 5 (0.2%) patients had Endometrial Cancer. Conclusion: For a general evaluation, H/S is an important tool in premenopausal women. Hysteroscopic findings and histopathological diagnoses may show a good correlation in experienced hands.

References

  • 1. Munro MG, Critchley HOD, Fraser IS, Haththotuwa R, Kriplani A, Bahamondes L et al. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynecol Obstet. 2018143:393-408.
  • 2. Wieser F, Tempfer C, Kurz C, Nagele F. Hysteroscopy in 2001: a comprehensive review. Acta Obstet Gynecol Scand. 2001 Jan 180(9):773–83
  • 3. Volman RF The menstrual cycle, in Freidman E,editor, Major problems in obstetrics and gynecology, WB Saunders Co.,Philadelphia,1977.
  • 4. Treolar AE, Boynton RE, Borghild GB, Brown BW. Variation of the human menstrual cycle through reproductive life. Int J Fertil.196712:77
  • 5. Shwayder JM. Pathophysiology of abnormal uterine bleeding. Obstet Gynecol Clin North Am. 2000 Jun 127(2):219–34.
  • 6. Nesse RE. Abnormal vaginal bleeding in perimenopausal women. Am Fam Physician. 198940(1):185.
  • 7. Grimes DA. Diagnostic dilation and curettage: A reappraisal. Am J Obstet Gynecol. 1982 Jan 1142(1):1–6
  • 8. Dijkhuizen FPHLJ, Brölmann HAM, Potters AE, Bongers MY, Heintz APM. The accuracy of transvaginal ultrasonography in the diagnosis of endometrial abnormalities. Obstet Gynecol. 1996 Mar 187(3):345–9.
  • 9. Yela DA, Hidalgo SR, Pereira KC, Gabiatti JR, Monteiro IM. Comparative study of transvaginal sonography and outpatient hysteroscopy for the detection of intrauterine diseases. Acta Med Port. 201124:65–70
  • 10. Gimpelson RJ, Rappold HO. A comparative study between panoramic hysteroscopy with directed biopsies and dilatation and curettage: A review of 276 cases. Am J Obstet Gynecol. 1988 Mar 1158(3, Part 1):489–92
  • 11. Ricci JU. Gynecologic surgery and instruments of the nineteenth century prior to the anntiseptic age. In the Development of Gynecologic Surgery and Instruments. Philedelphia Blakiston.1949:326-8
  • 12. Word B, Gravlee LC, Widemon GL. The fallacy of simple uterine curettage. Obstet Gynecol 195812:642-5
  • 13. Stock RJ, Kanbour A. Prehysterectomy curettage. Obstet Gynecol 197545:537-41
  • 14. Stovall T, Solomon S, Ling V. Endometrial sampling prior to hysterectomy. Obstet Gynecol 198973:405-9
  • 15. Nagele F, O’Connor H, Davies A, Badawy A, Mohamed H, Magos A. Obstet Gynecol 1996 88:87-92
  • 16. Taylor PJ. Hysteroscopy: where have we been, where are we going? J Reprod Med. 199338:757-62.
  • 17. Molloy D,Crosdale S.National trends in gynaecological endoscopic surgery. Aust N Z J Obstet Gynaecol. 199636:27-31.
  • 18. Bettochi S, Nappi L, Ceci O, et al. Office hysteroscopy. Obstetrics and gynecology clinics of North America: advances in laparoscopy and hysteroscopy techniques, Philadelphia: W.B. Saunders Company 2004. p. 641–54.
  • 19. Serden S. Diagnostic hysteroscopy to evaluate the cause of abnormal uterine bleeding. Obstet Gynecol Clin North Am 200027:277–86
  • 20. Tsai MC, Goldstein SR. Office diagnosis and management of abnormal uterine bleeding.Clin Obstet Gynecol. 2012 55:635-50.
  • 21. Emanuel MH. New developments in hysteroscopy. Best Pract Res Clin Obstet Gynaecol. 2013 27:421-9
  • 22. Emanuel MH, Verdel MJC, Stas H, Wamsteker K, Lammes FB. An audit of true prevalence of intra-uterine pathology: the hysteroscopical findings controlled for patient selection in 1202 patients with abnormal uterine bleeding. Gynaecol Endosc. 19954:237-41 . 23. Jennigs JC. Abnormal uterine bleeding. Med Clin North Am. 199579:1357-76.
  • 24. Hemalatha AN, Pai MR, Raghuveer CV. Endometrial aspiration cytology by various techniques. J Indian Med Assoc. 2011109:426-7.
  • 25. Itzkowic D. Hysteroscopy. Its place in modern gynaecology. Aust Fam Physician. 199221:425-9.
  • 26. Lasmar RB, Dias R, Barrozo PR, Oliveira MA, Coutinho Eda S, da Rosa DB.Prevalence of hysteroscopic findings and histologic diagnoses in patients with abnormal uterine bleeding. Fertil Steril. 200889:1803-7
  • 27. Mettler L,Wendland EM, Patel P, Caballero R, Schollmeyer T. Hysteroscopy: an analysis of 2-year experience. JSLS 20026:195– 7
  • 28. Baggish MS, Barbot J. Contact hysteroscopy. Clin Obstet Gynecol. 198326:219–41
  • 29. Preuttipan S,Linasmita V,Theppisiai U. Diagnostic hysteroscopy: a result of 125 patient AT Ramathudbodi Hoapital. J Med Assoc Thai. 199780:575-9.
  • 30. Kulkarni S,Wynter HH. Diagnistic hysteroscopy. West Indian Med J. 199241:160-1.
  • 31. Hamou JE. Microhysteroscopy: a new procedure and its original applications in gynecology. J Reprod Med. 1981 26:375–82.
  • 32. Pasqualotto EB, Margossian H, Price LL, et al. Accuracy of preoperative diagnostic tools and outcome of hysteroscopic management of menstrual dysfunction. J Am Assoc Gynecol Laparosc. 20007:201–9
  • 33. de Wit AC, Vleugels MP, de Kruif JH. Diagnostic hysteroscopy: a valuable diagnostic tool in the diagnosis of structural intra-cavital pathology and endometrial hyperplasia or carcinoma?. Six years of experience with non-clinical diagnostic hysteroscopy. Eur J Obstet Gynecol Reprod Biol. 2003 10110:79-82.
  • 34. Guin G, Sandhu SK, Lele A, Khare S.Hysteroscopy in evaluation of abnormal uterine bleeding. J Obstet Gynaecol India. 2011 61:546- 9.
  • 35. Iossa A, Coanferoni L,Ciatto S, Cecchini S, Campatelli C, Lo Stumbo F. Hysteroscopy and endometrial cancer dianosis: a reciew of 2007 consecutive examinations in self referred parients. Tumori. 199177:479-83.

Anormal Uterin Kanama Olan Kadınlarda Histeroskopik ve Patolojik Bulguların Değerlendirilmesi

Year 2024, Volume: 10 Issue: 1, 277 - 288, 15.05.2024

Abstract

Giriş: Anormal uterin kanama (AUK) genellikle iyi huylu patolojilerin belirtisi olmakla birlikte endometriyal hiperplazi veya kanserlerin de en sık görülen semptomu olarak karşımıza çıkabilir. Histeroskopi bu patolojilerin doğrudan görüntülenmesine olanak sağladığından büyük bir teşhis doğruluğuna sahiptir. Çalışmamızda, Anormal uterin kanaması olup histeroskopi ve biyopsi yapılan kadınların histeroskopik bulgularını ve histopatolojik sonuçlarının değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmamızdan Ocak 2018-2023 tarihlerin arasından hastanemize başvuranı ve anormali uterin kanama tanısı koyulanı 2440 hasta retrospektif olarak değerlendirilmiştir. Hastaların demografik özellikleri hastane veritabanından elde edilmiştir. Histeroskopiler tercihen adet döngüsünün erken foliküler fazında kanamanın olmadığı veya çok az kanamanın olduğu dönemde gerçekleştirildi. Bulgular: AUK nedeniyle histereskopi yapılan hastalarda histopatolojik tanı doğrulanmadan önce elde edilen bulgular değerlendirildiğinde 1320(%54) hastada herhangi bir intrauterin patoloji görülmedi. Çalışma grubundaki 890(%36,4) hastada Endometrial polip saptanmış olup, en sık bildirilen histeroskopik bulgu olarak not edilmiştir. 115(%5,1) hastada leiomyom, 70(%2,8) hastada endometriyal hiperplazi, 25(%1) hastada intrauterin araç (RİA) kaybı, 15(%0,6) hastada intrauterin adezyon, 5(%0,2) hastada endometrium kanseri saptanmıştır. AUK nedeniyle histeroskopi yapılan hastalarda histopatolojik olarak elde edilen sonuçlar değerlendirildiğinde 1390(%56,9) hastada herhangi bir intrauterin patoloji görülmedi. 830(%34) hastada Endometrial polip saptanmış olup, en sık bildirilen histopatolojik bulgu olarak not edilmiştir. Çalışma grubundaki 110(%4,5) hastada leiomyom, 65(%2,6) hastada endometriyal hiperplazi, 25(%1) hastada intrauterin araç kaybı, 15(%0,6) hastada intrauterin adezyon, 5 (%0,2) hastada endometrium kanseri vakası saptanmıştır. Sonuç: Genel bir değerlendirme için histeroskopi premenopozal kadınlarda önemli bir araçtır. Histeroskopik bulgular ve histopatolojik tanılar deneyimli ellerde iyi bir korelasyon gösterebilir.

References

  • 1. Munro MG, Critchley HOD, Fraser IS, Haththotuwa R, Kriplani A, Bahamondes L et al. The two FIGO systems for normal and abnormal uterine bleeding symptoms and classification of causes of abnormal uterine bleeding in the reproductive years: 2018 revisions. Int J Gynecol Obstet. 2018143:393-408.
  • 2. Wieser F, Tempfer C, Kurz C, Nagele F. Hysteroscopy in 2001: a comprehensive review. Acta Obstet Gynecol Scand. 2001 Jan 180(9):773–83
  • 3. Volman RF The menstrual cycle, in Freidman E,editor, Major problems in obstetrics and gynecology, WB Saunders Co.,Philadelphia,1977.
  • 4. Treolar AE, Boynton RE, Borghild GB, Brown BW. Variation of the human menstrual cycle through reproductive life. Int J Fertil.196712:77
  • 5. Shwayder JM. Pathophysiology of abnormal uterine bleeding. Obstet Gynecol Clin North Am. 2000 Jun 127(2):219–34.
  • 6. Nesse RE. Abnormal vaginal bleeding in perimenopausal women. Am Fam Physician. 198940(1):185.
  • 7. Grimes DA. Diagnostic dilation and curettage: A reappraisal. Am J Obstet Gynecol. 1982 Jan 1142(1):1–6
  • 8. Dijkhuizen FPHLJ, Brölmann HAM, Potters AE, Bongers MY, Heintz APM. The accuracy of transvaginal ultrasonography in the diagnosis of endometrial abnormalities. Obstet Gynecol. 1996 Mar 187(3):345–9.
  • 9. Yela DA, Hidalgo SR, Pereira KC, Gabiatti JR, Monteiro IM. Comparative study of transvaginal sonography and outpatient hysteroscopy for the detection of intrauterine diseases. Acta Med Port. 201124:65–70
  • 10. Gimpelson RJ, Rappold HO. A comparative study between panoramic hysteroscopy with directed biopsies and dilatation and curettage: A review of 276 cases. Am J Obstet Gynecol. 1988 Mar 1158(3, Part 1):489–92
  • 11. Ricci JU. Gynecologic surgery and instruments of the nineteenth century prior to the anntiseptic age. In the Development of Gynecologic Surgery and Instruments. Philedelphia Blakiston.1949:326-8
  • 12. Word B, Gravlee LC, Widemon GL. The fallacy of simple uterine curettage. Obstet Gynecol 195812:642-5
  • 13. Stock RJ, Kanbour A. Prehysterectomy curettage. Obstet Gynecol 197545:537-41
  • 14. Stovall T, Solomon S, Ling V. Endometrial sampling prior to hysterectomy. Obstet Gynecol 198973:405-9
  • 15. Nagele F, O’Connor H, Davies A, Badawy A, Mohamed H, Magos A. Obstet Gynecol 1996 88:87-92
  • 16. Taylor PJ. Hysteroscopy: where have we been, where are we going? J Reprod Med. 199338:757-62.
  • 17. Molloy D,Crosdale S.National trends in gynaecological endoscopic surgery. Aust N Z J Obstet Gynaecol. 199636:27-31.
  • 18. Bettochi S, Nappi L, Ceci O, et al. Office hysteroscopy. Obstetrics and gynecology clinics of North America: advances in laparoscopy and hysteroscopy techniques, Philadelphia: W.B. Saunders Company 2004. p. 641–54.
  • 19. Serden S. Diagnostic hysteroscopy to evaluate the cause of abnormal uterine bleeding. Obstet Gynecol Clin North Am 200027:277–86
  • 20. Tsai MC, Goldstein SR. Office diagnosis and management of abnormal uterine bleeding.Clin Obstet Gynecol. 2012 55:635-50.
  • 21. Emanuel MH. New developments in hysteroscopy. Best Pract Res Clin Obstet Gynaecol. 2013 27:421-9
  • 22. Emanuel MH, Verdel MJC, Stas H, Wamsteker K, Lammes FB. An audit of true prevalence of intra-uterine pathology: the hysteroscopical findings controlled for patient selection in 1202 patients with abnormal uterine bleeding. Gynaecol Endosc. 19954:237-41 . 23. Jennigs JC. Abnormal uterine bleeding. Med Clin North Am. 199579:1357-76.
  • 24. Hemalatha AN, Pai MR, Raghuveer CV. Endometrial aspiration cytology by various techniques. J Indian Med Assoc. 2011109:426-7.
  • 25. Itzkowic D. Hysteroscopy. Its place in modern gynaecology. Aust Fam Physician. 199221:425-9.
  • 26. Lasmar RB, Dias R, Barrozo PR, Oliveira MA, Coutinho Eda S, da Rosa DB.Prevalence of hysteroscopic findings and histologic diagnoses in patients with abnormal uterine bleeding. Fertil Steril. 200889:1803-7
  • 27. Mettler L,Wendland EM, Patel P, Caballero R, Schollmeyer T. Hysteroscopy: an analysis of 2-year experience. JSLS 20026:195– 7
  • 28. Baggish MS, Barbot J. Contact hysteroscopy. Clin Obstet Gynecol. 198326:219–41
  • 29. Preuttipan S,Linasmita V,Theppisiai U. Diagnostic hysteroscopy: a result of 125 patient AT Ramathudbodi Hoapital. J Med Assoc Thai. 199780:575-9.
  • 30. Kulkarni S,Wynter HH. Diagnistic hysteroscopy. West Indian Med J. 199241:160-1.
  • 31. Hamou JE. Microhysteroscopy: a new procedure and its original applications in gynecology. J Reprod Med. 1981 26:375–82.
  • 32. Pasqualotto EB, Margossian H, Price LL, et al. Accuracy of preoperative diagnostic tools and outcome of hysteroscopic management of menstrual dysfunction. J Am Assoc Gynecol Laparosc. 20007:201–9
  • 33. de Wit AC, Vleugels MP, de Kruif JH. Diagnostic hysteroscopy: a valuable diagnostic tool in the diagnosis of structural intra-cavital pathology and endometrial hyperplasia or carcinoma?. Six years of experience with non-clinical diagnostic hysteroscopy. Eur J Obstet Gynecol Reprod Biol. 2003 10110:79-82.
  • 34. Guin G, Sandhu SK, Lele A, Khare S.Hysteroscopy in evaluation of abnormal uterine bleeding. J Obstet Gynaecol India. 2011 61:546- 9.
  • 35. Iossa A, Coanferoni L,Ciatto S, Cecchini S, Campatelli C, Lo Stumbo F. Hysteroscopy and endometrial cancer dianosis: a reciew of 2007 consecutive examinations in self referred parients. Tumori. 199177:479-83.
There are 34 citations in total.

Details

Primary Language Turkish
Subjects Obstetrics and Gynaecology
Journal Section Research Article
Authors

Ufuk Atlıhan 0000-0002-2109-1373

Eyuphan Ozgozen 0000-0003-3395-3222

Begüm Ertan 0000-0002-0370-7509

Early Pub Date May 23, 2024
Publication Date May 15, 2024
Submission Date February 18, 2024
Acceptance Date March 17, 2024
Published in Issue Year 2024 Volume: 10 Issue: 1

Cite

APA Atlıhan, U., Ozgozen, E., & Ertan, B. (2024). Anormal Uterin Kanama Olan Kadınlarda Histeroskopik ve Patolojik Bulguların Değerlendirilmesi. International Anatolia Academic Online Journal Health Sciences, 10(1), 277-288.

International Anatolia Academic Online Journal Health Sciences