Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri

Alirıza Ünsal; Mehmet Tanrısev; Cemalettin Oluç

doi:10.5606/fng.btd.2016.002

Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri

Abstract

Amaç: Bu çalışmada böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri araştırıldı. Hastalar ve yöntemler: Çalışmaya böbrek nakli yapılan ve Tepecik Eğitim ve Araştırma Hastanesi Nefroloji Kliniği’nde takip edilen 100 hasta (68 erkek, 32 kadın; ort. yaş 42.1±11.4 yıl; dağılım 17-68 yıl) dahil edildi. Hastaların demografik özellikleri, biyokimyasal verileri, immünsüpresif tedavileri ve biyopsi sonuçları poliklinik takip dosyalarından retrospektif olarak kaydedildi.

Bulgular: 1000 mg/gün üzerindeki değerler proteinüri olarak tanımlandı ve 36 hastada proteinüri saptandı. Bu 36 hastanın 16’sına biyopsi yapıldı. Akut rejeksiyonlar proteinürinin önde gelen nedenlerindendi. Ayrıca, proteinüri düzeyi 1000 mg/gün’ün altında olan 64 hastanın 21’ine renal biyopsi uygulandı. Bu grupta nonspesifik biyopsi sonuçları en sık rastlanan bulgulardı. İmmünsüpresif ilaç kullanımı açısından 1000 mg/gün’den fazla proteinürisi olan hasta oranları benzerdi. Böbrek nakli yapılan hastalarda proteinüri sıklılığı %36 idi. Demografik veriler açısından gruplar arasında anlamlı farklılık yoktu.

Sonuç: Proteinüri düzeyleri daha yüksek olan hastalarda akut rejeksiyon en yaygın biyopsi sonucuydu. Beklenenin tersine, immünsüpresif tedavinin mTOR inhibitörlerinde anlamlı proteinüri sıklığı gözlenmedi.

Keywords

İmmunsüpresif tedavi, böbrek nakli, proteinüri

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Alirıza Ünsal

Mehmet Tanrısev This is me

Cemalettin Oluç This is me

Publication Date

March 8, 2016

Submission Date

March 8, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 2 Number: 1

DOI

https://doi.org/10.5606/fng.btd.2016.002

IZ

https://izlik.org/JA86KF35CH

Cite

RIS / Bibtex

APA

Ünsal, A., Tanrısev, M., & Oluç, C. (2016). Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 2(1), 4-11. https://doi.org/10.5606/fng.btd.2016.002

AMA

1.Ünsal A, Tanrısev M, Oluç C. Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2016;2(1):4-11. doi:10.5606/fng.btd.2016.002

Chicago

Ünsal, Alirıza, Mehmet Tanrısev, and Cemalettin Oluç. 2016. “Böbrek Nakli Yapılan Hastalarda Proteinüri Sıklığı Ve Nedenleri”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2 (1): 4-11. https://doi.org/10.5606/fng.btd.2016.002.

EndNote

Ünsal A, Tanrısev M, Oluç C (March 1, 2016) Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2 1 4–11.

IEEE

[1]A. Ünsal, M. Tanrısev, and C. Oluç, “Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri”, İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 2, no. 1, pp. 4–11, Mar. 2016, doi: 10.5606/fng.btd.2016.002.

ISNAD

Ünsal, Alirıza - Tanrısev, Mehmet - Oluç, Cemalettin. “Böbrek Nakli Yapılan Hastalarda Proteinüri Sıklığı Ve Nedenleri”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 2/1 (March 1, 2016): 4-11. https://doi.org/10.5606/fng.btd.2016.002.

JAMA

1.Ünsal A, Tanrısev M, Oluç C. Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2016;2:4–11.

MLA

Ünsal, Alirıza, et al. “Böbrek Nakli Yapılan Hastalarda Proteinüri Sıklığı Ve Nedenleri”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 2, no. 1, Mar. 2016, pp. 4-11, doi:10.5606/fng.btd.2016.002.

Vancouver

1.Alirıza Ünsal, Mehmet Tanrısev, Cemalettin Oluç. Böbrek nakli yapılan hastalarda proteinüri sıklığı ve nedenleri. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2016 Mar. 1;2(1):4-11. doi:10.5606/fng.btd.2016.002