The four horsemen of neurodegenerative diseases Alzheimer, Parkinson, Huntington and amyotrophic lateral skleroz; clinical definition and experimental models

Abstract

Along with the increase in the life span in the world and our country, the elderly population brings with different problems. During this life span destruction of nerve cells and clinical manifestations revealing after that constitute the group of diseases called "neurodegenerative diseases". Some neurodegenerative diseases are related to genetic factors rather than age. The emergence mechanisms of these diseases and development of new therapies are only possible by establishing experimental models capable of work in experimental animals. In this review, clinical features of neurogenerative diseases and pharmalogical/transgenic methods used in experimental model of neurodegenerative diseases will be mentioned.

Keywords

• Experimental models
• neurodegeneration
• neurodegenerative diseases

Nörodejeneratif hastalıklarda mahşerin 4 atlısı Alzheimer, Parkinson, Huntington ve amiyotrofik lateral skleroz: Klinik tanımlama ve deneysel modeller

Abstract

Dünyada ve ülkemizde yaşam süresinin artışı ile birlikte yaşlı nüfus beraberinde farklı sorunlar da getirmektedir. Bu uzun yaşam süresi boyunca oluşan sinir hücrelerinin harabiyeti ve sonucunda ortaya çıkan klinik tablolar “nörodejeneratif hastalıklar” denilen hastalık grubunu oluşturmaktadır. Bazı nörodejeneratif hastalıklar ise yaşlanmadan çok genetik faktörlerle ilişkilidir. Bu hastalıkların oluşum mekanizmalarının ortaya konması ve yeni tedavilerin geliştirilmesi ancak bu hastalıkları deney hayvanlarında çalışmayı mümkün kılacak deneysel modellerin oluşturulmasıyla mümkündür. Bu derlemede, nörodejeneratif hastalıkların kliniği ve deneysel modellemesinde kullanılan farmakolojik/transgenik yöntemlere değinilecektir.

Keywords

• Deneysel modeller
• nörodejenerasyon
• nörodejeneratif hastalıklar

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