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Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient

Year 2015, Volume: 1 Issue: 1, 28 - 32, 18.08.2015

Mehtap Üçer Neslihan Yılmaz Yonca Çağatay Mari Benli Levent Ulusoy Murat Akyıldız Şule Yavuz

https://doi.org/10.5606/fng.btd.2015.005

Abstract

Osteonecrosis is the destruction of bone as a result of temporary or permanent cessation of blood supply to the bones. Trauma, drugs, infections, hypercoagulability and solid organ transplantation are the most common causes. Osteonecrosis has been reported in many case series after renal, liver and cardiac transplantation; mainly in areas adjacent to the joints, especially on hip. Here, we are reporting multifocal osteonecrosis with osteomyelitis including diaphyseal region of the tibia in a patient with liver transplantation.

Keywords: Infection; liver transplantation; osteonecrosis.

Keywords

Infection; liver transplantation; osteonecrosis

References

  • Li H, Zhang J, He JW, Wang K, Wang GS, Jiang N, et al. Symptomatic osteonecrosis of the femoral head after adult orthotopic liver transplantation. Chin Med J (Engl) 2012;125:2422-6.
  • Lieberman JR, Scaduto AA, Wellmeyer E. Symptomatic osteonecrosis of the hip after orthotopic liver transplantation. J Arthroplasty 2000;15:767-71.
  • Guichelaar MM, Schmoll J, Malinchoc M, Hay JE. Fractures and avascular necrosis before and after orthotopic liver transplantation: long-term follow-up and predictive factors. Hepatology 2007;46:1198-207.
  • Papagelopoulos PJ, Hay JE, Galanis EC, Morrey BF. Total joint arthroplasty in orthotopic liver transplant recipients. J Arthroplasty 1996;11:889-92.
  • Horiuchi H, Hashikura Y, Hisa K, Saito N, Ikegami T, Nakazawa Y, et al. Osteonecrosis of the femoral head in Japanese adults after liver transplantation: a preliminary report. J Orthop Sci 2004;9:119-21.
  • Takao M, Sakai T, Nishii T, Yoshikawa H, Takahara S, Sugano N. Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients. Rheumatol Int 2011;31:165-70.
  • Bradbury G, Benjamin J, Thompson J, Klees E, Copeland J. Avascular necrosis of bone after cardiac transplantation. Prevalence and relationship to administration and dosage of steroids. J Bone Joint Surg [Am] 1994;76:1385-8.
  • Powell C, Chang C, Naguwa SM, Cheema G, Gershwin ME. Steroid induced osteonecrosis: An analysis of steroid dosing risk. Autoimmun Rev 2010;9:721-43.
  • Lieberman JR, Scaduto AA, Wellmeyer E. Symptomatic osteonecrosis of the hip after orthotopic liver transplantation. J Arthroplasty 2000;15:767-71.
  • Lieberman JR, Roth KM, Elsissy P, Dorey FJ, Kobashigawa JA. Symptomatic osteonecrosis of the hip and knee after cardiac transplantation. J Arthroplasty 2008;23:90-6.
  • Guichelaar MM, Schmoll J, Malinchoc M, Hay JE. Fractures and avascular necrosis before and after orthotopic liver transplantation: long-term follow-up and predictive factors. Hepatology 2007;46:1198-207.
  • Shibatani M, Fujioka M, Arai Y, Takahashi K, Ueshima K, Okamoto M, et al. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head. Acta Orthop 2008;79:631-6.
  • Abbott KC, Koff J, Bohen EM, Oglesby RJ, Agodoa LY, Lentine KL, et al. Maintenance immunosuppression use and the associated risk of avascular necrosis after kidney transplantation in the United States. Transplantation 2005;79:330-6.
  • Diniz-Freitas M, López-Cedrşn JL, Fernández
  • Sanromán J, García-García A, Fernández-Feijoo J, Diz-Dios P. Oral bisphosphonate-related osteonecrosis of the jaws: Clinical characteristics of a series of 20 cases in Spain. Med Oral Patol Oral Cir Bucal 2012;17:751-8.
  • Gupta S, Jain P, Kumar P, Parikh PM. Zoledronic acid induced osteonecrosis of tibia and femur. Indian J Cancer 2009;46:249-50.
  • Blacksin MF, Kloser PC, Simon J. Avascular necrosis of bone in human immunodeficiency virus infected patients. Clin Imaging 1999;23:314-8.
  • Blacksin MF, Finzel KC, Benevenia J. Osteomyelitis originating in and around bone infarcts: giant sequestrum phenomena. AJR Am J Roentgenol 2001;176:387-91.
  • Markov G, Dobro J, Shankman S, Belmont HM. Enterococcal arthritis with avascular necrosis in a lupus patient. Br J Rheumatol 1996;35:595-7.
  • Phillips FM, Pottenger LA. Acute septic arthritis in chronic osteonecrosis of the hip. J Rheumatol 1988;15:1713-6.
  • Lee YK, Lee YJ, Ha YC, Kim KC, Koo KH.
  • Septic arthritis of the hip in patients with femoral head osteonecrosis. Arch Orthop Trauma Surg 2011;131:1585-90.
  • Galindo M, Mateo I, Pablos JL. Multiple avascular necrosis of bone and polyarticular septic arthritis in patients with systemic lupus erythematosus. Rheumatol Int 2005;25:72-6.
  • Phillips FM, Pottenger LA. Acute septic arthritis
  • in chronic osteonecrosis of the hip. J Rheumatol 1988;15:1713-6.
  • Habermann ET, Friedenthal RB. Septic arthritis
  • associated with avascular necrosis of the femoral head. Clin Orthop Relat Res 1978;134:325-31.
  • Wideman RF, Prisby RD. Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis. Front Endocrinol (Lausanne) 2013;3:183.
  • Smeltzer MS, Gillaspy AF. Molecular pathogenesis of staphylcoccal osteomyelitis. Poult Sci 2000;79:1042-9.
  • McNamee PT, Smyth JA. Bacterial chondronecrosis with osteomyelitis ('femoral head necrosis') of broiler chickens: a review. Avian Pathol 2000;29:253-70.

Karaciğer nakli yapılan bir hastada multifokal osteonekroz ve osteomiyelit

Year 2015, Volume: 1 Issue: 1, 28 - 32, 18.08.2015

Mehtap Üçer Neslihan Yılmaz Yonca Çağatay Mari Benli Levent Ulusoy Murat Akyıldız Şule Yavuz

https://doi.org/10.5606/fng.btd.2015.005

Abstract

Osteonekroz (ON), kemiklerin kanlanmasının kalıcı ya da geçici olarak kesilmesi ile meydana gelen kemik yıkımıdır. En sık nedenleri arasında; travma, ilaçlar, enfeksiyonlar, hiperkoagülabilite ve solid organ nakli sayılabilir. Bir çok olgu serisinde, böbrek, karaciğer ve kalp nakli sonrasında özellikle kalçada olmak üzere, eklem çevresinde osteonekroz gelişebildiği bildirilmiştir. Bu makalede karaciğer nakli sonrasında ortaya çıkan, tibianın diafiz bölgesi dahil olmak üzere multifokal yerleşimli, osteomiyelitin eşlik ettiği bir osteonekroz olgusu sunuldu

Keywords

Enfeksiyon; karaciğer transplantasyonu; osteonekroz

References

  • Li H, Zhang J, He JW, Wang K, Wang GS, Jiang N, et al. Symptomatic osteonecrosis of the femoral head after adult orthotopic liver transplantation. Chin Med J (Engl) 2012;125:2422-6.
  • Lieberman JR, Scaduto AA, Wellmeyer E. Symptomatic osteonecrosis of the hip after orthotopic liver transplantation. J Arthroplasty 2000;15:767-71.
  • Guichelaar MM, Schmoll J, Malinchoc M, Hay JE. Fractures and avascular necrosis before and after orthotopic liver transplantation: long-term follow-up and predictive factors. Hepatology 2007;46:1198-207.
  • Papagelopoulos PJ, Hay JE, Galanis EC, Morrey BF. Total joint arthroplasty in orthotopic liver transplant recipients. J Arthroplasty 1996;11:889-92.
  • Horiuchi H, Hashikura Y, Hisa K, Saito N, Ikegami T, Nakazawa Y, et al. Osteonecrosis of the femoral head in Japanese adults after liver transplantation: a preliminary report. J Orthop Sci 2004;9:119-21.
  • Takao M, Sakai T, Nishii T, Yoshikawa H, Takahara S, Sugano N. Incidence and predictors of osteonecrosis among cyclosporin- or tacrolimus-treated renal allograft recipients. Rheumatol Int 2011;31:165-70.
  • Bradbury G, Benjamin J, Thompson J, Klees E, Copeland J. Avascular necrosis of bone after cardiac transplantation. Prevalence and relationship to administration and dosage of steroids. J Bone Joint Surg [Am] 1994;76:1385-8.
  • Powell C, Chang C, Naguwa SM, Cheema G, Gershwin ME. Steroid induced osteonecrosis: An analysis of steroid dosing risk. Autoimmun Rev 2010;9:721-43.
  • Lieberman JR, Scaduto AA, Wellmeyer E. Symptomatic osteonecrosis of the hip after orthotopic liver transplantation. J Arthroplasty 2000;15:767-71.
  • Lieberman JR, Roth KM, Elsissy P, Dorey FJ, Kobashigawa JA. Symptomatic osteonecrosis of the hip and knee after cardiac transplantation. J Arthroplasty 2008;23:90-6.
  • Guichelaar MM, Schmoll J, Malinchoc M, Hay JE. Fractures and avascular necrosis before and after orthotopic liver transplantation: long-term follow-up and predictive factors. Hepatology 2007;46:1198-207.
  • Shibatani M, Fujioka M, Arai Y, Takahashi K, Ueshima K, Okamoto M, et al. Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral head. Acta Orthop 2008;79:631-6.
  • Abbott KC, Koff J, Bohen EM, Oglesby RJ, Agodoa LY, Lentine KL, et al. Maintenance immunosuppression use and the associated risk of avascular necrosis after kidney transplantation in the United States. Transplantation 2005;79:330-6.
  • Diniz-Freitas M, López-Cedrşn JL, Fernández
  • Sanromán J, García-García A, Fernández-Feijoo J, Diz-Dios P. Oral bisphosphonate-related osteonecrosis of the jaws: Clinical characteristics of a series of 20 cases in Spain. Med Oral Patol Oral Cir Bucal 2012;17:751-8.
  • Gupta S, Jain P, Kumar P, Parikh PM. Zoledronic acid induced osteonecrosis of tibia and femur. Indian J Cancer 2009;46:249-50.
  • Blacksin MF, Kloser PC, Simon J. Avascular necrosis of bone in human immunodeficiency virus infected patients. Clin Imaging 1999;23:314-8.
  • Blacksin MF, Finzel KC, Benevenia J. Osteomyelitis originating in and around bone infarcts: giant sequestrum phenomena. AJR Am J Roentgenol 2001;176:387-91.
  • Markov G, Dobro J, Shankman S, Belmont HM. Enterococcal arthritis with avascular necrosis in a lupus patient. Br J Rheumatol 1996;35:595-7.
  • Phillips FM, Pottenger LA. Acute septic arthritis in chronic osteonecrosis of the hip. J Rheumatol 1988;15:1713-6.
  • Lee YK, Lee YJ, Ha YC, Kim KC, Koo KH.
  • Septic arthritis of the hip in patients with femoral head osteonecrosis. Arch Orthop Trauma Surg 2011;131:1585-90.
  • Galindo M, Mateo I, Pablos JL. Multiple avascular necrosis of bone and polyarticular septic arthritis in patients with systemic lupus erythematosus. Rheumatol Int 2005;25:72-6.
  • Phillips FM, Pottenger LA. Acute septic arthritis
  • in chronic osteonecrosis of the hip. J Rheumatol 1988;15:1713-6.
  • Habermann ET, Friedenthal RB. Septic arthritis
  • associated with avascular necrosis of the femoral head. Clin Orthop Relat Res 1978;134:325-31.
  • Wideman RF, Prisby RD. Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis. Front Endocrinol (Lausanne) 2013;3:183.
  • Smeltzer MS, Gillaspy AF. Molecular pathogenesis of staphylcoccal osteomyelitis. Poult Sci 2000;79:1042-9.
  • McNamee PT, Smyth JA. Bacterial chondronecrosis with osteomyelitis ('femoral head necrosis') of broiler chickens: a review. Avian Pathol 2000;29:253-70.
There are 30 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Mehtap Üçer This is me

Neslihan Yılmaz This is me

Yonca Çağatay This is me

Mari Benli This is me

Levent Ulusoy This is me

Murat Akyıldız This is me

Şule Yavuz This is me

Publication Date August 18, 2015
Published in Issue Year 2015 Volume: 1 Issue: 1

Cite

APA Üçer, M., Yılmaz, N., Çağatay, Y., Benli, M., et al. (2015). Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, 1(1), 28-32. https://doi.org/10.5606/fng.btd.2015.005
AMA Üçer M, Yılmaz N, Çağatay Y, Benli M, Ulusoy L, Akyıldız M, Yavuz Ş. Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. August 2015;1(1):28-32. doi:10.5606/fng.btd.2015.005
Chicago Üçer, Mehtap, Neslihan Yılmaz, Yonca Çağatay, Mari Benli, Levent Ulusoy, Murat Akyıldız, and Şule Yavuz. “Multifocal Osteonecrosis and Osteomyelitis in a Liver Transplant Recipient”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1, no. 1 (August 2015): 28-32. https://doi.org/10.5606/fng.btd.2015.005.
EndNote Üçer M, Yılmaz N, Çağatay Y, Benli M, Ulusoy L, Akyıldız M, Yavuz Ş (August 1, 2015) Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 1 28–32.
IEEE M. Üçer, N. Yılmaz, Y. Çağatay, M. Benli, L. Ulusoy, M. Akyıldız, and Ş. Yavuz, “Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient”, İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 1, no. 1, pp. 28–32, 2015, doi: 10.5606/fng.btd.2015.005.
ISNAD Üçer, Mehtap et al. “Multifocal Osteonecrosis and Osteomyelitis in a Liver Transplant Recipient”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1/1 (August 2015), 28-32. https://doi.org/10.5606/fng.btd.2015.005.
JAMA Üçer M, Yılmaz N, Çağatay Y, Benli M, Ulusoy L, Akyıldız M, Yavuz Ş. Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1:28–32.
MLA Üçer, Mehtap et al. “Multifocal Osteonecrosis and Osteomyelitis in a Liver Transplant Recipient”. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 1, no. 1, 2015, pp. 28-32, doi:10.5606/fng.btd.2015.005.
Vancouver Üçer M, Yılmaz N, Çağatay Y, Benli M, Ulusoy L, Akyıldız M, Yavuz Ş. Multifocal osteonecrosis and osteomyelitis in a liver transplant recipient. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015;1(1):28-32.
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