Abstract
Diabetes mellitus (DM) is a chronic metabolic syndrome with hyperglycemia. It consists because of insulin deficiency/resistant, and ends up with disregulation of protein, carbohydrate and lipid metabolism. Diabetes mellitus is one of the most common chronic disease. Genetic and environmental factors act together on development of DM. The modelling of DM and investigating its complications is an important subject. It could be possible to try new agents to inhibit development of macro and microvascular complications of DM, by experimental modelling. Streptozocin and alloxan are most frequently used agents to create DM model. In recent years, use of mutant spontaneous diabetic rats inspite of DM modelling is current. Thus, direct tissue damage during diabetic induction by streptozocin and alloxan is avoided and effects related hyperglycemia come in sight simply
References
- Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001;50:537-46.
- Lenzen S, Tiedge M, Jorns A, Munday R. Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan. In: Shafrir E, editor. Lessons from Animal Diabetes. Boston: Birkhauser; 1996. p. 113-22.
- Federiuk IF, Casey HM, Quinn MJ, Wood MD, Ward WK. Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment. Comp Med 2004;54:252-7.
- Katsumata K, Katsumata K Jr, Katsumata Y. Protective effect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats. Horm Metab Res 1992;24:508-10.
- Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J, et al. Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers. Arch Soc Esp Oftalmol 2006;81:27-32. [Abstract]
- Mythili MD, Vyas R, Akila G, Gunasekaran S. Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microsc Res Tech 2004;63:274-81.
- Patel R, Shervington A, Pariente JA, Martinez-Burgos MA, Salido GM, Adeghate E, et al. Mechanism of exocrine pancreatic insufficiency in streptozotocin- induced type 1 diabetes mellitus. Ann N Y Acad Sci 2006;1084:71-88.
- Pascoe WS, Storlien LH. Inducement by fat feeding of basal hyperglycemia in rats with abnormal beta- cell function. Model for study of etiology and pathogenesis of NIDDM. Diabetes 1990;39:226-33.
- Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med 2005;22:359-70.
- Yu WJ, Juang SW, Chin WT, Chi TC, Chang CJ, Cheng JT. Insulin restores neuronal nitric oxide synthase expression in streptozotocin-induced diabetic rats. Life Sci 2000;68:625-34.
- Valentovic MA, Alejandro N, Betts Carpenter A, Brown PI, Ramos K. Streptozotocin (STZ) diabetes enhances benzo(alpha)pyrene induced renal injury in Sprague Dawley rats. Toxicol Lett 2006;164:214-20.
- Kazumi T, Yoshino G, Fujii S, Baba S. Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats. Cancer Res 1978;38:2144-7.
- Steiner H, Oelz O, Zahnd G, Foresch ER. Studies on islet cell regeneration, hyperplasia and intrainsular cellular interrelations in long lasting streptozotocin diabetes in rats. Diabetologia 1970;6:558-64.
- Awai M, Narasaki M, Yamanoi Y, Seno S. Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am J Pathol 1979;95:663-73.
- Chen D, Wang MW. Development and application of rodent models for type 2 diabetes. Diabetes Obes Metab 2005;7:307-17.
- Pickup JC, Williams G. Textbook of Diabetes. 2nd ed. Vol. 1. Oxford: Blackwell Science Inc; 2002.
- Like AA, Butler L, Williams RM, Appel MC, Weringer EJ, Rossini AA. Spontaneous autoimmune diabetes mellitus in the BB rat. Diabetes 1982;31:7-13.
Abstract
Diyabetes mellitus, insülin eksikliği veya insülinin etkisiz kalması sonucu oluşan; birlikte karbonhidrat, protein ve yağ metabolizması düzensizliğinin eşlik ettiği hiperglisemi ile seyreden kronik metabolik bir sendromdur. Diyabetes mellitus toplumda en sık g.rülen kronik hastalıklardan biridir.
Diyabet hastalığının gelişiminde genetik ve çevresel faktörler birlikte rol oynar. Deney hayvanlarında diyabet hastalığının modellenmesi ve komplikasyon mekanizmalarının anlaşılması önemli bir konudur. Diyabete bağlı mikro ve makrovasküler komplikasyonların gelişiminin önlenmesi için yeni ajanların denenmesi modelleme ile mümkün olmaktadır. Streptozosin ve alloksan deneysel diyabet oluşturmak için en sık kullanılan ajanlardır.
Son yıllarda genetik mutasyonlu spontan diyabetik sıçanların kullanılması daha güncel bir konudur. Böylece diyabetik indüksiyon için kullanılan streptozosin ve alloksana bağlı oluşabilecek direkt doku hasarı önlenmekte ve sadece hiperglisemiye bağlı etkilerin daha yalın olarak ortaya çıkması sağlanmaktadır.
Anahtar sözcükler: Alloksan; diyabet modelleme; Goto-Kakizaki; streptozosin.
References
- Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001;50:537-46.
- Lenzen S, Tiedge M, Jorns A, Munday R. Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan. In: Shafrir E, editor. Lessons from Animal Diabetes. Boston: Birkhauser; 1996. p. 113-22.
- Federiuk IF, Casey HM, Quinn MJ, Wood MD, Ward WK. Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment. Comp Med 2004;54:252-7.
- Katsumata K, Katsumata K Jr, Katsumata Y. Protective effect of diltiazem hydrochloride on the occurrence of alloxan- or streptozotocin-induced diabetes in rats. Horm Metab Res 1992;24:508-10.
- Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J, et al. Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers. Arch Soc Esp Oftalmol 2006;81:27-32. [Abstract]
- Mythili MD, Vyas R, Akila G, Gunasekaran S. Effect of streptozotocin on the ultrastructure of rat pancreatic islets. Microsc Res Tech 2004;63:274-81.
- Patel R, Shervington A, Pariente JA, Martinez-Burgos MA, Salido GM, Adeghate E, et al. Mechanism of exocrine pancreatic insufficiency in streptozotocin- induced type 1 diabetes mellitus. Ann N Y Acad Sci 2006;1084:71-88.
- Pascoe WS, Storlien LH. Inducement by fat feeding of basal hyperglycemia in rats with abnormal beta- cell function. Model for study of etiology and pathogenesis of NIDDM. Diabetes 1990;39:226-33.
- Rees DA, Alcolado JC. Animal models of diabetes mellitus. Diabet Med 2005;22:359-70.
- Yu WJ, Juang SW, Chin WT, Chi TC, Chang CJ, Cheng JT. Insulin restores neuronal nitric oxide synthase expression in streptozotocin-induced diabetic rats. Life Sci 2000;68:625-34.
- Valentovic MA, Alejandro N, Betts Carpenter A, Brown PI, Ramos K. Streptozotocin (STZ) diabetes enhances benzo(alpha)pyrene induced renal injury in Sprague Dawley rats. Toxicol Lett 2006;164:214-20.
- Kazumi T, Yoshino G, Fujii S, Baba S. Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats. Cancer Res 1978;38:2144-7.
- Steiner H, Oelz O, Zahnd G, Foresch ER. Studies on islet cell regeneration, hyperplasia and intrainsular cellular interrelations in long lasting streptozotocin diabetes in rats. Diabetologia 1970;6:558-64.
- Awai M, Narasaki M, Yamanoi Y, Seno S. Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am J Pathol 1979;95:663-73.
- Chen D, Wang MW. Development and application of rodent models for type 2 diabetes. Diabetes Obes Metab 2005;7:307-17.
- Pickup JC, Williams G. Textbook of Diabetes. 2nd ed. Vol. 1. Oxford: Blackwell Science Inc; 2002.
- Like AA, Butler L, Williams RM, Appel MC, Weringer EJ, Rossini AA. Spontaneous autoimmune diabetes mellitus in the BB rat. Diabetes 1982;31:7-13.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Review |
| Authors | |
| Publication Date | August 18, 2015 |
| Published in Issue | Year 2015 Volume: 1 Issue: 1 |
