Year 2015, Volume 1 , Issue 1, Pages 48 - 51 2015-08-18

Alzheimer hastalığı tip 3 diyabet midir?

Oytun ERBAŞ [1]


Alzheimer's Disease (AD) is the most common cause of dementia. The term of 'type 3 diabetes' is constituted to point out the insulin deficiency and resistant in brain of people with AD. In postmortem studies about AD, it has ben detected that insulin receptors, insulin-like growth factor 1 and 2, insulin messenger ribonucleic acid are decreased in brain. Insulin can pass through brain-blood-barrier, besides it can be synthesized by a group of neuron internally. Gene expression of insulin is present in mature and immature neurons of mammals. Insulin has important effects on regulation of energy metabolism of neurons and neuronal recovery. Decreased glucose uptake and adenosine triphosphate production in the case of insulin deficiency, leads an impairment in neuronal homeostasis. Insulin can increase cognitive functions without changing plasma glucose and insulin levels when it applied intranasally. Insulin and its sub-pathways will maintain its current importance about improvement and protection of cognitive functions

Alzheimer hastalığı (AH) en sık g.rülen demanstır. Tip 3 diyabet terimi, AH’de beyinde oluşan insülin eksikliği ve direncine dikkat çekmek için kullanılan bir terimdir. Postmortem çalışmalarda AH hastalarının beyinlerinde insülin resept.rü, insülin benzeri büyüme fakt.rü 1 ve 2 ve insülin haberci ribonükleik asit düzeylerinde azalma vardır. İnsülin kan beyin bariyerine geçmekte ayrıca beyinde bir grup nöron tarafından internal olarak da sentez edilmektedir. İnsülin gen ekspresyonu matur ve immatur memeli nöronal hücrelerinde mevcuttur. İnsülin nöronlardaki enerji metabolizmasını düzenlemesi nöronal sağkalım üzerinde önemli etki yapar. İnsülin eksikliğinde oluşan azalmış glikoz alımı ve adenozin trifosfat üretimi nöronal homeostazın bozulmasına neden olur. Intranazal insülin plazma glikoz ve insülin konsantrasyonunda değişiklik olmadan kognitif fonksiyonlarda artma oluşturmuştur. İnsülin ve alt yolları gelecekte bellek fonksiyonlarının düzeltilmesinde ve korunmasında güncel önemini korumaya devam edecektir.

Anahtar sözcükler: Alzheimer hastalığı; demans; insülin; tip 3 diyabet.

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Authors

Author: Oytun ERBAŞ

Dates

Publication Date : August 18, 2015

Bibtex @ { ibufntd103953, journal = {İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi}, issn = {2149-4401}, eissn = {2547-9466}, address = {}, publisher = {Bayçınar Tıbbi Yayıncılık ve Reklam Hiz. Tic. Ltd. Şti.}, year = {2015}, volume = {1}, pages = {48 - 51}, doi = {10.5606/fng.btd.2015.010}, title = {Alzheimer hastalığı tip 3 diyabet midir?}, key = {cite}, author = {Erbaş, Oytun} }
APA Erbaş, O . (2015). Alzheimer hastalığı tip 3 diyabet midir? . İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi , 1 (1) , 48-51 . DOI: 10.5606/fng.btd.2015.010
MLA Erbaş, O . "Alzheimer hastalığı tip 3 diyabet midir?" . İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 (2015 ): 48-51 <https://dergipark.org.tr/en/pub/ibufntd/issue/7896/103953>
Chicago Erbaş, O . "Alzheimer hastalığı tip 3 diyabet midir?". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 (2015 ): 48-51
RIS TY - JOUR T1 - Alzheimer hastalığı tip 3 diyabet midir? AU - Oytun Erbaş Y1 - 2015 PY - 2015 N1 - doi: 10.5606/fng.btd.2015.010 DO - 10.5606/fng.btd.2015.010 T2 - İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi JF - Journal JO - JOR SP - 48 EP - 51 VL - 1 IS - 1 SN - 2149-4401-2547-9466 M3 - doi: 10.5606/fng.btd.2015.010 UR - https://doi.org/10.5606/fng.btd.2015.010 Y2 - 2020 ER -
EndNote %0 İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi Alzheimer hastalığı tip 3 diyabet midir? %A Oytun Erbaş %T Alzheimer hastalığı tip 3 diyabet midir? %D 2015 %J İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi %P 2149-4401-2547-9466 %V 1 %N 1 %R doi: 10.5606/fng.btd.2015.010 %U 10.5606/fng.btd.2015.010
ISNAD Erbaş, Oytun . "Alzheimer hastalığı tip 3 diyabet midir?". İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi 1 / 1 (August 2015): 48-51 . https://doi.org/10.5606/fng.btd.2015.010
AMA Erbaş O . Alzheimer hastalığı tip 3 diyabet midir?. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015; 1(1): 48-51.
Vancouver Erbaş O . Alzheimer hastalığı tip 3 diyabet midir?. İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi. 2015; 1(1): 48-51.
IEEE O. Erbaş , "Alzheimer hastalığı tip 3 diyabet midir?", İstanbul Bilim Üniversitesi Florence Nightingale Tıp Dergisi, vol. 1, no. 1, pp. 48-51, Aug. 2015, doi:10.5606/fng.btd.2015.010