Diabetes Mellitus Etiyopatogenezinde İlişkili Faktörlerden Biri: Eritrosit İçi Sıvı Hacmi

Abstract

Amaç: Bu çalışmanın amacı Diabetes Mellitus (DM) hastaları ve sağlıklı kontrollerde eritrosit içi sıvı hacmi, eritrosit indeksleri ve biyokimyasal parametrelerin düzeylerini araştırmak ve eritrosit içi sıvı hacmi ile bu parametreler arasındaki ilişkiyi değerlendirmektir. Yöntem: Çalışmaya 42 DM'li hasta ve 40 sağlıklı kontrol dahil edildi. Biyokimyasal parametreler otomatik analizör kullanılarak ölçüldü. Otomatik hematoloji analiz cihazı kullanılarak tam kan sayımı yapıldı ve mikrosantrifüj yöntemi kullanılarak eritrosit içi sıvı hacimleri ölçüldü. Bulgular: Hasta grubunda eritrosit içi sıvı hacmi, glikolize hemoglobin (HbA1c) ve glukoz düzeyleri kontrol grubuna göre daha yüksek, ortalama eritrosit hacmi (MCV), potasyum (K) ve sodyum (Na) değerleri ise hasta grubunda kontrol grubuna göre daha düşüktü. Öte yandan hasta grubunda eritrosit içi sıvı hacmi ile ortalama eritrosit hemoglobin konsantrasyonu (MCHC), magnezyum (Mg) ve K değerleri arasında negatif korelasyon saptandı. Sonuç: Bulgular, eritrosit içi sıvı hacminin DM etyopatogenezinde etkili bir hemodinamik parametre olabileceğini göstermiştir. Bu veriler doğrultusunda eritrosit içi sıvı hacminin hastalığın seyrinin takibinde dikkate alınması gereken önemli bir faktör olduğu önerilebilir.

Keywords

• Diabetes mellitus
• eritrosit içi sıvı hacmi
• eritrosit indeksleri
• biyokimyasal parametreler

One of the Factor Associated with Etiopathogenesis of Diabetes Mellitus: Intraerythrocyte Fluid Volume

Abstract

Aim: The aim of the present study was to investigate the levels of intraerythrocyte fluid volume, erythrocyte indices, and biochemical parameters and to evaluate the relationship between intraerythrocyte fluid volume and these parameters in patients with Diabetes Mellitus (DM) and healthy controls. Method: The study included 42 patients with DM and 40 healthy controls. Biochemical parameters were measured using an automated analyzer. Complete blood counts were performed using an automated hematology analyzer, and intraerythrocyte fluid volumes were measured using the microcentrifugation method. Results: Intraerythrocyte fluid volume, glycated hemoglobin (HbA1c), and glucose levels were higher in the patient group than in the control group, whereas mean corpuscular volume (MCV), potassium (K), and sodium (Na) values were lower in the patient group than in the control group. On the other hand, a negative correlation was found between intraerythrocyte fluid volume and mean corpuscular hemoglobin concentration (MCHC), magnesium (Mg), and K values in the patient group. Conclusion: Studies findings indicated that intraerythrocyte fluid volume may be an effective hemodynamic parameter in the etiopathogenesis of DM. In line with these data, it can be suggested that intraerythrocyte fluid volume is an important factor that should be considered in monitoring the progression of the disease.

Keywords

• Diabetes mellitus
• intraerythrocyte fluid volume
• erythrocyte indices
• biochemical parameters

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