Metoklopramid Kullanımı Sonrası Gelişen Malign Nöroleptik Sendrom: Olgu Sunumu

Abstract

Malign nöroleptik sendrom (MNS), antipsikotik ilaçların nadir görülen bir yan etkisidir. Sendrom, rijidite, titreme, taşikardi, ateş yüksekliği, bilinç değişikliği, otonomik disfonksiyon, yüksek serum kreatinin fosfokinaz (CPK) ve lökositoz ile karakterize olan bir tablodur. Antipsikotik ilaç kullanan hastalarda MNS insidansı %0,02-3 arasında değişir. Etiyolojide antiemetiklerin kullanımı, elektrolit düzensizlikleri (özellikle hipopotasemi), organik beyin sendromu, malnütrisyon da rol oynayabilir. MNS, yaşamı tehdit eden bir durum olup, tanı ve tedavisinde zorluk olabilir. Bu olgu sunumunda, bilinen kronik hastalığı olmayan hastada gelişen tedavisi ve tanısında oldukça zorlandığımız bir malign nöroleptik sendrom olgusunun sunulması amaçlanmıştır.

Keywords

• Metoklopramid,Malign Nöroleptik Sendrom,yoğun bakım

Malignant Neuroleptic Syndrome After Metoclopramide Use: Case Report

Abstract

Malignant neuroleptic syndrome (MNS) is a rare side effect of antipsychotic drugs. The syndrome is characterized by rigidity, tremor, tachycardia, fever, altered consciousness, autonomic dysfunction, high serum creatinine phosphokinase (CPK) and leukocytosis. The incidence of MNS in patients whom use antipsychotic drugs varies between 0.02-3%. In the etiology of MNS, use of antiemetics, electrolyte disorders (especially hypopotasemia), organic brain syndrome and malnutrition, may also play a role. MNS is a life-threatening condition and may have difficulty in diagnosis and treatment. In this case report, we aimed to present a case of malignant neuroleptic syndrome which we had difficulty in the treatment and diagnosis of a patient without known any chronic disease.

Keywords

• Malignant neuroleptic syndrome,metoclopramide,intensive care

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