Year 2019, Volume , Issue 9, Pages 864 - 880 2019-12-31

Prevalence of FV, FXIII, ACE, ApoE Gene Variants and Effects on Coronary Artery Disease Profile in Giresun
Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması

Ayşegül Başak AKADAM-TEKER [1] , Erhan TEKER [2] , Hülya YILMAZ AYDOĞAN [3] , Aynur DAĞLAR ADAY [4]


Aim: Atherosclerosis-induced Coronary Artery Disease (CAD) is a multifactorial and polygenic complex disease. In recent studies, some genetic variants associated with CAD have come to the fore. In our study, four gene regions were analyzed for blood coagulation and lipid metabolism in order to determine the genetic profile which may be susceptible to CAD patients in Turkey (in living Giresun). These gene regions are: FV-Leiden (rs6025) (FVL), FXIII 163G> T (V34L) (rs: 5985), ACE (Angiotensin-converting enzyme) (rs1799752 I/D Polymorphism), ApoE rs429358).

Materials and Methods: In this study, 89 control and 174 patients were used. ApoE genotypes were determined by real time polymerase chain reaction (RT-PCR). FVL, FXIII, ACE were determined by PCR method.

Results: ACE D and ApoE e4 allele frequencies were lower in the control group (p = 0.026 and p = 0.015, respectively). Serum total cholesterol (p = 0.038) and LDL-K (p = 0.054) levels were higher in patients with FV A allele compared to those with GG genotype in the patient group. The presence of FXIII L allele was 31.9% in patients without MI. The presence of L allele shows a protective effect against the risk of MI (p = 0.06, OR = 0.464, 95% CI = 0.202-1.09).

Conclusion: None of the gene variants investigated in our study directly correlated with CAD development. However, the inferences we have obtained from our study, in which the gene variants investigated can indirectly affect CAD risk factors.

Amaç: Ateroskleroz kaynaklı Koroner Arter Hastalığı (KAH), multifaktöriyel ve poligenik kompleks bir hastalıktır. Son yıllarda yapılan çalışmalarda KAH ile ilişkili bazı genetik varyantlar öne çıkmıştır. Bizim çalışmamızda da Türkiye’de Giresun ilinde yaşayanlarda KAH’na yatkınlık sağlayabilecek olan genetik profili çıkarmak için kan koagülasyonu ve lipid metabolizması ile ilgili olarak dört gen bölgesi analiz edildi. Bu gen bölgeleri FV-Leiden (rs6025) (FVL), FXIII 163G> T (V34L) (rs:5985), ACE (Angiotensin-converting enzyme) (rs1799752 I/D polimorfizm), ApoE (Apolipoprotein-E) (rs7412 ve rs429358) şeklindedir.

Yöntem: Çalışmamızda 89 kontrol ve 174 hasta kullanılmıştır. ApoE gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR), FVL, FXIII, ACE PCR yöntemi kullanılarak genotipler belirlenmiştir.

Bulgular: Hasta grubunda ACE D ve ApoE e4 allel frekansları kontrol grubunda düşük saptandı (sırasıyla p=0,026 ve p=0,015). Hasta grubunda, FV A allel taşıyanlar (GA+AA) GG genotipine sahip bireylerle karşılaştırıldığında serum total kolesterol (p=0,038) ve LDL-K (p=0,054) düzeyleri yüksek gözlendi. MI geçirmeyenlerde FXIII L allel varlığı % 31,9’dur. L allel varlığı MI riskine karşı koruyucu etki göstermektedir (p=0,06, OR=0,464, %95 CI=0,202-1,06).

Sonuç: Çalışmamızda araştırılan gen varyantlarının hiçbirinin direkt olarak KAH gelişimi ile ilişkisini gözlemlemedik. Ancak araştırılan gen varyantlarının dolaylı olarak KAH risk faktörlerine etkili olabilecekleri çalışmamızdan elde ettiğimiz çıkarımlardandır.

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Primary Language tr
Subjects Medicine
Journal Section Articles
Authors

Orcid: 0000-0003-3618-0560
Author: Ayşegül Başak AKADAM-TEKER (Primary Author)
Institution: GİRESUN ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ GENETİK ANABİLİM DALI
Country: Turkey


Orcid: 0000-0002-0234-7548
Author: Erhan TEKER
Institution: Giresun Üniversitesi, A. İlhan Özdemir Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği,
Country: Turkey


Orcid: 0000-0002-8837-6664
Author: Hülya YILMAZ AYDOĞAN
Institution: İSTANBUL ÜNİVERSİTESİ, AZİZ SANCAR DENEYSEL TIP ARAŞTIRMA ENSTİTÜSÜ, MOLEKÜLER TIP ANABİLİM DALI
Country: Turkey


Orcid: 0000-0001-8072-0646
Author: Aynur DAĞLAR ADAY
Institution: İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, HEMATOLOJİ BİLİM DALI
Country: Turkey


Dates

Publication Date : December 31, 2019

Bibtex @research article { igusabder590895, journal = {İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi}, issn = {2536-4499}, eissn = {2602-2605}, address = {İstanbul Gelişim Üniversitesi Sağlık Bilimleri Yüksekokulu - Cihangir Mah. Şehit Jandarma Komando Er Hakan Öner Sk. No: 1 Avcılar / İstanbul / Türkiye}, publisher = {İstanbul Gelisim University}, year = {2019}, volume = {}, pages = {864 - 880}, doi = {10.38079/igusabder.590895}, title = {Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması}, key = {cite}, author = {Akadam-teker, Ayşegül Başak and Teker, Erhan and Yılmaz Aydoğan, Hülya and Dağlar Aday, Aynur} }
APA Akadam-teker, A , Teker, E , Yılmaz Aydoğan, H , Dağlar Aday, A . (2019). Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması . İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi , (9) , 864-880 . DOI: 10.38079/igusabder.590895
MLA Akadam-teker, A , Teker, E , Yılmaz Aydoğan, H , Dağlar Aday, A . "Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması" . İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi (2019 ): 864-880 <https://dergipark.org.tr/en/pub/igusabder/issue/50564/590895>
Chicago Akadam-teker, A , Teker, E , Yılmaz Aydoğan, H , Dağlar Aday, A . "Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması". İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi (2019 ): 864-880
RIS TY - JOUR T1 - Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması AU - Ayşegül Başak Akadam-teker , Erhan Teker , Hülya Yılmaz Aydoğan , Aynur Dağlar Aday Y1 - 2019 PY - 2019 N1 - doi: 10.38079/igusabder.590895 DO - 10.38079/igusabder.590895 T2 - İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi JF - Journal JO - JOR SP - 864 EP - 880 VL - IS - 9 SN - 2536-4499-2602-2605 M3 - doi: 10.38079/igusabder.590895 UR - https://doi.org/10.38079/igusabder.590895 Y2 - 2019 ER -
EndNote %0 İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması %A Ayşegül Başak Akadam-teker , Erhan Teker , Hülya Yılmaz Aydoğan , Aynur Dağlar Aday %T Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması %D 2019 %J İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi %P 2536-4499-2602-2605 %V %N 9 %R doi: 10.38079/igusabder.590895 %U 10.38079/igusabder.590895
ISNAD Akadam-teker, Ayşegül Başak , Teker, Erhan , Yılmaz Aydoğan, Hülya , Dağlar Aday, Aynur . "Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması". İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi / 9 (December 2020): 864-880 . https://doi.org/10.38079/igusabder.590895
AMA Akadam-teker A , Teker E , Yılmaz Aydoğan H , Dağlar Aday A . Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması. IGUSABDER. 2019; (9): 864-880.
Vancouver Akadam-teker A , Teker E , Yılmaz Aydoğan H , Dağlar Aday A . Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması. İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi. 2019; (9): 864-880.
IEEE A. Akadam-teker , E. Teker , H. Yılmaz Aydoğan and A. Dağlar Aday , "Giresun İlinde FV, FXIII, ACE, ApoE Gen Varyantlarının Prevelansı ve Koroner Arter Hastalığı Profiline Etkilerinin Araştırılması", İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, no. 9, pp. 864-880, Dec. 2020, doi:10.38079/igusabder.590895