Improving Upper Extremity Functionality in Children with Unilateral Cerebral Palsy with Action Observation Therapy

Year 2022, Issue: 18, 1052 - 1069, 31.12.2022

Sinem Erturan Mustafa Burak Bülent Elbasan

https://doi.org/10.38079/igusabder.1094792

Abstract

Action Observation Therapy (AOT) is a neurorehabilitation-based treatment approach that supports the restoration of the central nervous system by imitating the same movements after monitoring the movements. It is known as a new rehabilitation approach that utilizes the neurophysiological mechanism to activate the neural structures that perform the function in many diseases such as cerebral palsy, Parkinson's, stroke, orthopedic injuries, Alzheimer's and speech disorders. Studies in healthy individuals and individuals with neurological or orthopedic effects; it is known that AOT application induces facilitation in the observer's motor system and supports the action-perception matching mechanism. This narrative review was planned to look through the available information on the use and effectiveness of AOT programs for the upper extremity in children with Cerebral Palsy (CP). The use of AOT is appropriate in the upper extremity rehabilitation of children with CP, since it can be easily adapted to different conditions, facilitates motor learning by supporting neural plasticity, and is economical; however, it is thought that more detailed studies are needed to determine the optimal application principles in terms of protocol, duration and application method.

Keywords

Cerebral palsy, upper extremity, rehabilitation, neuroplasticity

Eylem Gözlem Terapisi ile Unilateral Serebral Palsili Çocuklarda Üst Ekstremite Fonksiyonelliğinin Geliştirilmesi

Abstract

Eylem Gözlem Terapisi (EGT) hareketlerin izlenmesi sonrası aynı hareketlerin taklit edilmesi ile merkezi sinir sistemi restorasyonunu destekleyen nörorehabilitasyon temelli bir tedavi yaklaşımıdır. Serebral palsi, parkinson, inme, ortopedik yaralanmalar, alzheimer ve konuşma bozuklukları gibi pek çok hastalıkta, fonksiyonu gerçekleştiren nöral yapıları aktive etmek için nörofizyolojik mekanizmadan yararlanan yeni bir rehabilitasyon yaklaşımı olarak bilinir. Sağlıklı bireylerde ve nörolojik veya ortopedik etkilenimi olan bireylerde yapılan araştırmalar; EGT uygulamasının gözlemcinin motor sisteminde kolaylaştırmayı indüklediği ve eylem-algı eşleştirme mekanizmasını desteklediği bilinir. Bu derleme, Serebral Palsi (SP) tanılı çocuklarda üst ekstremiteye yönelik uygulanan EGT programlarının kullanımı ve etkinliği ile ilgili mevcut bilgileri gözden geçirmek amacıyla planlanmıştır. EGT kullanımının farklı koşullara kolayca adapte edilebilmesi, nöral plasitisiteyi destekleyerek motor öğrenmeyi fasilite etmesi ve ekonomik olması nedeniyle, SP’li çocukların üst ekstremite rehabilitasyonunda kullanımının uygun olduğu; ancak protokol, süre ve uygulama şekli açısından optimal uygulama prensiplerinin belirlenebilmesi için daha detaylı çalışmalara ihtiyaç olduğu düşünülmektedir.

Keywords

Serebral palsi, üst ekstremite, rehabilitasyon, nöroplastisite

References

• Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, Dan B, Jacobsson B. A report: The definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109(suppl 109):8-14.
• Oskoui M, Coutinho F, Dykeman J, Jetté N, Pringsheim T. An update on the prevalence of cerebral palsy: A systematic review and meta-analysis. Dev Med Child Neurol. 2013;55(6):509-519.
• Serdaroǧlu A, Cansu A, Özkan S, Tezcan S. Prevalence of cerebral palsy in Turkish children between the ages of 2 and 16 years. Developmental Medicine and Child Neurology. 2006;48(6):413-416.
• Cans C, De-la-Cruz J, Mermet M-A. Epidemiology of cerebral palsy. Paediatrics and Child Health. 2008;18(9):393-398.
• Himmelmann K, Hagberg G, Uvebrant P. The changing panorama of cerebral palsy in Sweden. X. Prevalence and origin in the birth-year period 1999-2002. Acta Paediatr. 2010;99(9):1337-1343.
• Ferrari A, Cioni G. The Spastic Forms of Cerebral Palsy: A Guide To The Assessment of Adaptive Functions: Springer; 2009.
• Eliasson A-C, Bonnier B, Krumlinde-Sundholm L. Clinical experience of constraint induced movement therapy in adolescents with hemiplegic cerebral palsy–a day camp model. Developmental Medicine and Child Neurology. 2003;45(5):357-360.
• Boxum AG, La Bastide‐Van Gemert S, Dijkstra LJ, Hamer EG, Hielkema T, Reinders‐Messelink HA, et al. Development of the quality of reaching in infants with cerebral palsy: a kinematic study. Developmental Medicine & Child Neurology. 2017;59(11):1164-1173.
• Sakzewski L, Ziviani J, Boyd R. Systematic review and meta-analysis of therapeutic management of upper-limb dysfunction in children with congenital hemiplegia. Pediatrics. 2009;123(6):e1111-e1122.
• Keeratisiroj O, Thawinchai N, Siritaratiwat W, Buntragulpoontawee M. Prognostic predictors for ambulation in Thai children with cerebral palsy aged 2 to 18 years. Journal of Child Neurology. 2015;30(13):1812-1818.
• Staudt M, Gerloff C, Grodd W, Holthausen H, Niemann G, Krägeloh-Mann I. Reorganization in congenital hemiparesis acquired at different gestational ages. Ann Neurol. 2004;56(6):854-863.
• Snodgrass SJ, Heneghan NR, Tsao H, Stanwell PT, Rivett DA, Van Vliet PM. Recognising neuroplasticity in musculoskeletal rehabilitation: a basis for greater collaboration between musculoskeletal and neurological physiotherapists. Manual Therapy. 2014;19(6):614-617.
• Sallés L, Gironès X, Martín-Casas P, Lafuente JV. A neurocognitive approach to recovery of movement following stroke. Physical Therapy Reviews. 2015;20(5-6):283-289.
• van Hedel HJ, Häfliger N, Gerber CN. Quantifying selective elbow movements during an exergame in children with neurological disorders: A pilot study. Journal of Neuroengineering and Rehabilitation. 2016;13(1):1-12.
• Novak I, Morgan C, Fahey M, et al. State of the Evidence Traffic Lights 2019: Systematic Review of Interventions for Preventing and Treating Children with Cerebral Palsy. Curr Neurol Neurosci Rep. 2020;20(2):3.
• Shi YX, Tian JH, Yang KH, Zhao Y. Modified constraint-induced movement therapy versus traditional rehabilitation in patients with upper-extremity dysfunction after stroke: A systematic review and meta-analysis. Arch Phys Med Rehabil. 2011;92(6):972-982.
• Gordon AM, Schneider JA, Chinnan A, Charles JR. Efficacy of a hand–arm bimanual intensive therapy (HABIT) in children with hemiplegic cerebral palsy: A randomized control trial. Developmental Medicine & Child Neurology. 2007;49(11):830-838.
• Manzoor N, Kashif M, Haroon B, Dastgir A, Iram H. Parent’s perception of constraint induced movement therapy in cerebral palsy management in rehabilitation centers of Lahore. Innovation. 2019;69(3):373-377.
• Chen Y-P, Howard AM. Effects of robotic therapy on upper-extremity function in children with cerebral palsy: A systematic review. Developmental Neurorehabilitation. 2016;19(1):64-71.
• Gilliaux M, Renders A, Dispa D, et al. Upper limb robot-assisted therapy in cerebral palsy: A single-blind randomized controlled trial. Neurorehabilitation and Neural Repair. 2015;29(2):183-192.
• Lo K, Stephenson M, Lockwood C. The economic cost of robotic rehabilitation for adult stroke patients: A systematic review. JBI Database System Rev Implement Rep. 2019;17(4):520-547.
• Ramachandran VS, Altschuler EL. The use of visual feedback, in particular mirror visual feedback, in restoring brain function. Brain. 2009;132(7):1693-1710.
• Buccino G. Action observation treatment: A novel tool in neurorehabilitation. Philosophical Transactions of the Royal Society B: Biological Sciences. 2014;369(1644):20130185.
• Bhasin A, Srivastava MP, Kumaran SS, Bhatia R, Mohanty S. Neural interface of mirror therapy in chronic stroke patients: a functional magnetic resonance imaging study. Neurology India. 2012;60(6):570-6.
• Buccino G, Lui F, Canessa N, et al. Neural circuits involved in the recognition of actions performed by nonconspecifics: an FMRI study. J Cogn Neurosci. 2004;16(1):114-126.
• Buccino G, Solodkin A, Small SL. Functions of the mirror neuron system: implications for neurorehabilitation. Cogn Behav Neurol. 2006;19(1):55-63.
• Lacourse MG, Orr EL, Cramer SC, Cohen MJ. Brain activation during execution and motor imagery of novel and skilled sequential hand movements. Neuroimage. 2005;27(3):505-519.
• Munzert J, Lorey B, Zentgraf K. Cognitive motor processes: the role of motor imagery in the study of motor representations. Brain Research Reviews. 2009;60(2):306-326.
• Fabbri-Destro M, Rizzolatti G. Mirror neurons and mirror systems in monkeys and humans. Physiology (Bethesda). 2008;23:171-179.
• Caspers S, Zilles K, Laird AR, Eickhoff SB. ALE meta-analysis of action observation and imitation in the human brain. Neuroimage. 2010;50(3):1148-1167.
• Buccino G. Lui F, Canessa N, Patteri I, Lagravinese G, Benuzzi F, et al. Neural circuits involved in the recognition of actions performed by nonconspecifics: an fMRI study. J Cogn Neurosci. 2004;16:114-126.
• Buccino G, Solodkin A, Small SL. Functions of the mirror neuron system: implications for neurorehabilitation. Cognitive and behavioral neurology. 2006;19(1):55-63.
• Sale P, Franceschini M. Action observation and mirror neuron network: A tool for motor stroke rehabilitation. Eur J Phys Rehabil Med. 2012;48(2):313-318.
• Grèzes J, Tucker M, Armony J, Ellis R, Passingham RE. Objects automatically potentiate action: An fMRI study of implicit processing. Eur J Neurosci. 2003;17(12):2735-2740.
• Jaywant A, Ellis TD, Roy S, Lin CC, Neargarder S, Cronin-Golomb A. Randomized controlled trial of a home-based action observation intervention to improve walking in Parkinson disease. Archives of physical medicine and rehabilitation. 2016;97(5):665-673.
• Kim JH, Lee BH. Action observation training for functional activities after stroke: A pilot randomized controlled trial. NeuroRehabilitation. 2013;33(4):565-574.
• Mezzarobba S, Grassi M, Pellegrini L, et al. Action observation plus sonification. A novel therapeutic protocol for Parkinson’s patient with freezing of gait. Frontiers in neurology. 2018;8:723.
• Simon-Martinez C, Mailleux L, Hoskens J, et al. Randomized controlled trial combining constraint-induced movement therapy and action-observation training in unilateral cerebral palsy: clinical effects and influencing factors of treatment response. Therapeutic advances in neurological disorders. 2020;13:1756286419898065.
• Rocca MA, Meani A, Fumagalli S, et al. Functional and structural plasticity following action observation training in multiple sclerosis. Multiple Sclerosis Journal. 2019;25(11):1472-1487.
• Park HR, Kim JM, Lee MK, Oh DW. Clinical feasibility of action observation training for walking function of patients with post-stroke hemiparesis: A randomized controlled trial. Clinical Rehabilitation. 2014;28(8):794-803.
• Hsieh YW, Lin YH, Zhu JD, Wu CY, Lin YP, Chen CC. Treatment effects of upper limb action observation therapy and mirror therapy on rehabilitation outcomes after subacute stroke: A pilot study. Behavioural Neurology. 2020;2020:6250524.
• Buccino G. Action observation treatment: A novel tool in neurorehabilitation. Philos Trans R Soc Lond B Biol Sci. 2014;369(1644):20130185.
• Di Pellegrino G, Fadiga L, Fogassi L, Gallese V, Rizzolatti G. Understanding motor events: a neurophysiological study. Experimental Brain Research. 1992;91(1):176-180.
• Fadiga L, Fogassi L, Pavesi G, Rizzolatti G. Motor facilitation during action observation: a magnetic stimulation study. J Neurophysiol. 1995;73(6):2608-2611.
• Rizzolatti G, Sinigaglia C. The functional role of the parieto-frontal mirror circuit: interpretations and misinterpretations. Nat Rev Neurosci. 2010;11(4):264-274.
• Small SL, Buccino G, Solodkin A. The mirror neuron system and treatment of stroke. Dev Psychobiol. 2012;54(3):293-310.
• Rizzolatti G, Craighero L. The mirror-neuron system. Annu Rev Neurosci. 2004;27:169-192.
• Cattaneo L, Rizzolatti G. The mirror neuron system. Arch Neurol. 2009;66(5):557-560.
• Buccino G, Binkofski F, Fink GR, et al. Action observation activates premotor and parietal areas in a somatotopic manner: An fMRI study. Eur J Neurosci. 2001;13(2):400-404.
• Wheaton KJ, Thompson JC, Syngeniotis A, Abbott DF, Puce A. Viewing the motion of human body parts activates different regions of premotor, temporal, and parietal cortex. Neuroimage. 2004;22(1):277-288.
• Penfield W, Rasmussen T. The cerebral cortex of man; a clinical study of localization of function. JAMA. 1950;144(16):1412
• Garrison KA, Winstein CJ, Aziz-Zadeh L. The mirror neuron system: a neural substrate for methods in stroke rehabilitation. Neurorehabilitation and Neural Repair. 2010;24(5):404-412.
• Quadrelli E, Anzani A, Ferri M, et al. Electrophysiological correlates of action observation treatment in children with cerebral palsy: A pilot study. Developmental Neurobiology. 2019;79(11-12):934-948.
• Ertelt D, Small S, Solodkin A, et al. Action observation has a positive impact on rehabilitation of motor deficits after stroke. Neuroimage. 2007;36 Suppl 2:T164-173.
• Sarasso E, Gemma M, Agosta F, Filippi M, Gatti R. Action observation training to improve motor function recovery: A systematic review. Archives of Physiotherapy. 2015;5(1):1-12.
• Ryan D, Fullen B, Rio E, Segurado R, Stokes D, O'Sullivan C. Effect of Action Observation Therapy in the Rehabilitation of Neurologic and Musculoskeletal Conditions: A Systematic Review. Arch Rehabil Res Clin Transl. 2021;3(1):100-106.
• Marangolo P, Caltagirone C. Options to enhance recovery from aphasia by means of non-invasive brain stimulation and action observation therapy. Expert Review of Neurotherapeutics. 2014;14(1):75-91.
• Simon-Martinez C, Mailleux L, Jaspers E, et al. Effects of combining constraint-induced movement therapy and action-observation training on upper limb kinematics in children with unilateral cerebral palsy: A randomized controlled trial. Scientific Reports. 2020;10(1):1-15.
• Meltzoff AN, Moore MK. Imitation of facial and manual gestures by human neonates. Science. 1977;198(4312):75-78.
• Paulus M, Hunnius S, Vissers M, Bekkering H. Imitation in infancy: Rational or motor resonance? Child Development. 2011;82(4):1047-1057.
• Nyström P. The infant mirror neuron system studied with high density EEG. Social Neuroscience. 2008;3(3-4):334-347.
• Guzzetta A, Boyd RN, Perez M, et al. UP-BEAT (Upper Limb Baby Early Action–observation Training): protocol of two parallel randomised controlled trials of action–observation training for typically developing infants and infants with asymmetric brain lesions. BMJ open. 2013;3(2):e002512.
• Gallese V, Rochat M, Cossu G, Sinigaglia C. Motor cognition and its role in the phylogeny and ontogeny of action understanding. Developmental Psychology. 2009;45(1):103-13.
• Buccino G, Arisi D, Gough P, et al. Improving upper limb motor functions through action observation treatment: A pilot study in children with cerebral palsy. Developmental Medicine & Child Neurology. 2012;54(9):822-828.
• Agosta F, Gatti R, Sarasso E, et al. Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. Journal of Neurology. 2017;264(1):88-101.
• Pelosin E, Avanzino L, Bove M, Stramesi P, Nieuwboer A, Abbruzzese G. Action observation improves freezing of gait in patients with Parkinson’s disease. Neurorehabilitation and Neural Repair. 2010;24(8):746-752.
• Pelosin E, Barella R, Bet C, et al. Effect of group-based rehabilitation combining action observation with physiotherapy on freezing of gait in Parkinson’s disease. Neural Plasticity. 2018;2018:4897276.
• Kim E, Kim K. Effect of purposeful action observation on upper extremity function in stroke patients. Journal of Physical Therapy Science. 2015;27(9):2867-2869.
• Kim JC, Lee HM. The effect of action observation training on balance and sit to walk in chronic stroke: A crossover randomized controlled trial. Journal of Motor Behavior. 2018;50(4):373-380.
• Moon Y, Bae Y. Backward walking observational training improves gait ability in patients with chronic stroke: Randomised controlled pilot study. International Journal of Rehabilitation Research. 2019;42(3):217-222.
• Son YL, Kim JW. The effects of mirror neuron system-based self-observation training on lower limb muscle activity and dynamic balance in patients with chronic stroke. Journal of Physical Therapy Science. 2018;30(10):1241-1244.
• Zhu M-H, Zeng M, Shi M-F, et al. Visual feedback therapy for restoration of upper limb function of stroke patients. International Journal of Nursing Sciences. 2020;7(2):170-178.
• Bellelli G, Buccino G, Bernardini B, Padovani A, Trabucchi M. Action observation treatment improves recovery of postsurgical orthopedic patients: evidence for a top-down effect? Archives of Physical Medicine and Rehabilitation. 2010;91(10):1489-1494.
• Villafañe JH, Isgrò M, Borsatti M, Berjano P, Pirali C, Negrini S. Effects of action observation treatment in recovery after total knee replacement: A prospective clinical trial. Clinical Rehabilitation. 2017;31(3):361-368.
• Bassolino M, Campanella M, Bove M, Pozzo T, Fadiga L. Training the motor cortex by observing the actions of others during immobilization. Cerebral Cortex. 2014;24(12):3268-3276.
• Buccino G, Molinaro A, Ambrosi C, et al. Action observation treatment improves upper limb motor functions in children with cerebral palsy: A combined clinical and brain imaging study. Neural Plasticity. 2018;2018:4843985.
• Jeong YA, Lee BH. Effect of action observation training on spasticity, gross motor function, and balance in children with diplegia cerebral palsy. Children. 2020;7(6):64-73.
• Kirkpatrick E, Pearse J, James P, Basu A. Effect of parent‐delivered action observation therapy on upper limb function in unilateral cerebral palsy: A randomized controlled trial. Developmental Medicine & Child Neurology. 2016;58(10):1049-1056.
• Sgandurra G, Ferrari A, Cossu G, Guzzetta A, Fogassi L, Cioni G. Randomized trial of observation and execution of upper extremity actions versus action alone in children with unilateral cerebral palsy. Neurorehabilitation and Neural Repair. 2013;27(9):808-815.
• Tung ML, Murphy IC, Griffin SC, et al. Observation of limb movements reduces phantom limb pain in bilateral amputees. Annals of Clinical and Translational Neurology. 2014;1(9):633-638.
• Marangolo P, Bonifazi S, Tomaiuolo F, et al. Improving language without words: First evidence from aphasia. Neuropsychologia. 2010;48(13):3824-3833.
• Stefan K, Cohen LG, Duque J, et al. Formation of a motor memory by action observation. Journal of Neuroscience. 2005;25(41):9339-9346.
• Mulder T. Motor imagery and action observation: Cognitive tools for rehabilitation. J Neural Transm (Vienna). 2007;114(10):1265-1278.
• Calvo-Merino B, Glaser DE, Grèzes J, Passingham RE, Haggard P. Action observation and acquired motor skills: An FMRI study with expert dancers. Cerebral Cortex. 2005;15(8):1243-1249.
• Porro CA, Facchin P, Fusi S, Dri G, Fadiga L. Enhancement of force after action observation: behavioural and neurophysiological studies. Neuropsychologia. 2007;45(13):3114-3121.
• Molinaro A, Micheletti S, Pagani F, et al. Action observation treatment in a tele-rehabilitation setting: a pilot study in children with cerebral palsy. Disability and Rehabilitation. 2020:1-6.
• Gatti R, Tettamanti A, Gough P, Riboldi E, Marinoni L, Buccino G. Action observation versus motor imagery in learning a complex motor task: A short review of literature and a kinematics study. Neuroscience Letters. 2013;540:37-42.
• Sakzewski L, Ziviani J, Boyd RN. Efficacy of upper limb therapies for unilateral cerebral palsy: A meta-analysis. Pediatrics. 2014;133(1):e175-e204.
• Alamer A, Melese H, Adugna B. Effectiveness of Action Observation Training on Upper Limb Motor Function in Children with Hemiplegic Cerebral Palsy: A Systematic Review of Randomized Controlled Trials. Pediatric Health, Medicine and Therapeutics. 2020;11:335-46.
• Ryan D, Fullen B, Rio E, Segurado R, Stokes D, O’Sullivan C. The effect of action observation therapy (AOT) in the rehabilitation of neurological and musculoskeletal conditions: A systematic review. Archives of Rehabilitation Research and Clinical Translation. 2021:100106.
• Kim DH. Comparison of short-and long-time action observation training (AOT) on upper limb function in children with cerebral palsy. Physiotherapy Practice and Research. 2020;41(1):53-58.
• Kim JY, Kim JM, Ko EY. The effect of the action observation physical training on the upper extremity function in children with cerebral palsy. J Exerc Rehabil. 2014;10(3):176-183.
• Beani E, Menici V, Ferrari A, Cioni G, Sgandurra G. Feasibility of a home-based action observation training for children with unilateral cerebral palsy: An explorative study. Frontiers in Neurology. 2020;11:16.
• Brandão MdB. Home‐based action observation treatment for children with unilateral cerebral palsy: strategies to promote intervention engagement. Developmental Medicine & Child Neurology. 2019;61(11):1246-1246.
• Rossi F, Savi F, Prestia A, Mongardi A, Demarchi D, Buccino G. Combining Action Observation Treatment with a Brain–Computer Interface System: Perspectives on Neurorehabilitation. Sensors. 2021;21(24):8504.
• Jung Y, Chung EJ, Chun HL, Lee BH. Effects of whole-body vibration combined with action observation on gross motor function, balance, and gait in children with spastic cerebral palsy: A preliminary study. Journal of Exercise Rehabilitation. 2020;16(3):249-257.
• Kim DH, An DH, Yoo WG. Effects of live and video form action observation training on upper limb function in children with hemiparetic cerebral palsy. Technology and Health Care. 2018;26(3):437-443.
• Nuara A, Avanzini P, Rizzolatti G, Fabbri‐Destro M. Efficacy of a home‐based platform for child‐to‐child interaction on hand motor function in unilateral cerebral palsy. Developmental Medicine & Child Neurology. 2019;61(11):1314-1322.