The Effect of Herbal Product Use on BMI and HbA1c in Patients with Diabetes

Year 2022, Issue: 18, 710 - 720, 31.12.2022

Gülay Yıldırım Mahruk Rashidi

https://doi.org/10.38079/igusabder.1169051

Abstract

Aim: Patients with diabetes can use herbal products to better manage the disease. The aim of this study is to examine the rate of herbal product use and the effect of herbal product use on Body Mass Index (BMI) and hemoglobin A1c (HbA1c) values in patients with diabetes.

Method: The descriptive and cross-sectional study was conducted in the diabetes outpatient clinic of a hospital in Istanbul with a total of 104 patients with diabetes. The data were collected using a data collection form, which questioned the patients' socio-demographic characteristics, disease information and herbal product use. Data analysis was performed using Chi-square, One-Sample Kolmogorov-Smirnov test and Mann Whitney U test in computer environment.

Results: The mean age of patients with diabetes was 61,08±9,3 years, the mean BMI was 26,3±5,4kg/m², and the mean HbA1c value was 6,9%±1,8%. The BMI and HbA1c values of the patients using herbal products were lower than the patients not using herbal products (respectively; p=,002; p=,047). It was determined that the duration of herbal product use did not affect BMI and HbA1c values (p>,05).

Conclusion: The use of herbal products was high in patients with diabetes. It was determined that olive leaf, cinnamon leaf, thyme juice, garlic, black sesame, blueberry, fenugreek seeds, French lavender and bitter almond were used as herbal products. Herbal product use decreased BMI and HbA1c values.

Keywords

Body mass index, herbal product, diabetes, hemoglobin A1c protein, Beden kütle indeksi, bitkisel ürün, diyabet, hemoglobin A1c proteini

Diyabetli Hastalarda Bitkisel Ürün Kullanımının BKİ ve HbA1c Üzerine Etkisi

Abstract

Amaç: Diyabet hastaları hastalığı daha iyi yönetebilmek için bitkisel ürün kullanabilmektedirler. Bu araştırmanın amacı diyabetli hastalarda bitkisel ürün kullanım oranını ve bitkisel ürün kullanımının Beden Kütle İndeksi (BKİ) ile hemoglobin A1c (HbA1c) değerleri üzerine etkisini incelemektir.

Yöntem: Tanımlayıcı ve kesitsel nitelikte olan araştırma İstanbul’da bir hastanenin diyabet polikliniğinde toplam 104 diyabetli hasta ile yürütülmüştür. Veriler hastaların sosyo demografik özellikleri, hastalık bilgileri ve bitkisel ürün kullanımına veri toplama formu yardımıyla ulaşılmıştır. Verilerin analizi bilgisayar ortamında Chi-square, One-Sample Kolmogorov-Smirnov testi ve Mann-Whitney U testi kullanılarak yapılmıştır.

Bulgular: Diyabetli hastaların yaş ortalaması 61,08±9,3 yıl; BKİ ortalamaları 26,3±5,4 kg/m²; HbA1c değer ortalamaları %6,9±%1,8 olarak bulunmuştur. Bitkisel ürün kullanan hastaların BKİ ve HbA1c değerleri, bitkisel ürün kullanmayan hastalara göre daha düşüktür (sırasıyla; p=,002; p=,047). Bitkisel ürün kullanım süresinin BKİ ve HbA1c değerlerini etkilemediği saptanmıştır (p>,05).

Sonuç: Diyabetli hastalarda bitkisel ürün kullanımı yüksek olduğu bulunmuştur. Bitkisel ürün olarak zeytin yaprağı, tarçın yaprağı, kekik suyu, sarımsak, çörek otu, yaban mersini, çemen tohumu, karabaş otu ve acı badem kullanıldığı saptanmıştır. Bitkisel ürün kullanımı BKİ ve HbA1c değerlerini düşürmüştür. 

Keywords

Beden kütle indeksi, bitkisel ürün, diyabet, hemoglobin A1c proteini

References

• Sun Hong, Saeedi P, Karuranga S, et al. IDF Diabetes atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022;183:1-13. doi:101016/j.diabres.2021.109119.
• Saeedi P, Salpea P, Karuranga S, et al. Mortality attributable to diabetes in 20–79 years old adults, 2019 estimates: Results from the international diabetes federation diabetes atlas. Diabetes Research and Clinical Practice. 2020;162:1-5. doi:101016/j.diabres.2020.108086.
• Türkiye Beslenme ve Sağlık Araştırması (TBSA) 2010: Beslenme Durumu ve Alışkanlıklarının Değerlendirilmesi Sonuç Raporu. Sağlık Araştırmaları Genel Müdürlüğü, Sağlık Bakanlığı Yayın No:931, Ankara 2014.
• Eroğlu N. Diyabetin komplikasyonlarından korunmak için tanı, tedavi ve izlem. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. 2019;4(1):31-33.
• Ching SM, Zakaria ZA, Paimin F, Jalalian M. Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: A cross-sectional study in Malaysia. BMC Complementary and Alternative Medicine. 2013;13(1):1-7.
• Koyu Bellikci E, Yürekli Şarer B, Özdemir N, Büyüktuncer Z. Tip 2 diabetes mellituslu hastaların bitkisel destek kullanım durumları. Akdeniz Tıp Dergisi. 2021;7(3):377-384. doi:10.53394/akd.979533.
• Pang GM, Li FX, Yan Y, et al, Herbal medicine in the treatment of patients with type 2 diabetes mellitus. Chinese Medical Journal. 2019;132(1):78-85. doi:10.1097/CM9.0000000000000006.
• Amirehsani KA, Wallace DC. Herbal self-care remedies of Latino/Hispanic immigrants for type 2 diabetes. Diabetes Education. 2013;39:828-840. doi:10.1177/0145721713504004.
• Başer T, Aypak C, Görpelioğlu S. Use of herbal products in type 2 diabetes mellitus patients. Family Medicine and Care. 2018;1(1):1-3. doi:10.15761/FMC.1000106.
• Karaman E, Erkin Ö, Senman S, Yıldırım Y. The use of herbal supplements by individuals with diabetes mellitus. JPMA. The Journal of the Pakistan Medical Association. 2018;68(4):587-594.
• Amaeze OU, Aderemi-Williams RI, Ayo-Vaughan MA, Ogundemuren DA, Ogunmola DS, Anyika EN. Herbal medicine use among type 2 diabetes mellitus patients in Nigeria: Understanding the magnitude and predictors of use. International Journal of Clinical Pharmacy. 2018,40(3):580-588. doi:10.1007/s11096-018-0648-2.
• Kifle ZD, Bayleyegn B, Tadesse TY, Woldeyohanins AE. Prevalence and associated factors of herbal medicine use among adult diabetes mellitus patients at government hospital, Ethiopia: An institutional-based cross-sectional study. Metabolism Open. 2021;(11):1-6. doi:10.1016/j.metop.2021.100120.
• Xu L, Li Y, Daj Y, Peng J. Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms. Pharmacological Research. 2018;130:451-465. doi:10.1016/j.phrs.2018.01.015.
• Grossman LD, Roscoe R, Shack A. Complementary and alternative medicine for diabetes. Canadian Journal of Diabetes. 2018;42:154-161. doi:10.1016/j.jcjd.2017.10.023.
• Çınar D, Yava A, Olgun N, Koyuncu A, Eti Aslan F. Use of herbal products and food supplements of type 2 diabetes patients. Health & Research Journal. 2022;8(3):219-230.
• Mekuria AB, Belachew SA, Tegegn HG, et al. Prevalence and correlates of herbal medicine use among type 2 diabetic patients in Teaching Hospital in Ethiopia: A cross-sectional study. BMC Complementary and Alternative Medicine. 2018;18(1):1-8. doi:10.1186/s12906-018-2147-3.
• Alqathama A, Alluhiabi G, Baghdadi H, et al. Herbal medicine from the perspective of type II diabetic patients and physicians: What is the relationship? BMC Complementary Medicine and Therapies. 2020;20(65):1-9. doi:10.1186/s12906-020-2854-4.
• Wainstein J, Ganz T, Boaz M, et al. Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats. Journal of Medicinal Food, 2012;15(7):605-610. doi:10.1089/jmf.2011.0243.
• Abunab H, Dator W, Hawamdeh S. Effect of olive leaf extract on glucose levels in diabetesinduced rats: A systematic review and meta-analysis. Journal of Diabetes. 2017;9:947-957. doi:10.1111/1753-0407.12508
• Rahimi HR, Mohammadpour AH, Dastani M, et al. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: A randomized clinical trial. Avicenna Journal of Phytomedicine. 2016;6(5):567-577.
• Rao AS, Hegde S, Pacioretty LM, DeBenedetto J, Babish JG. Nigella sativa and trigonella foenum-graecum supplemented chapatis safely improve HbA1c, body weight, waist circumference, blood lipids, and fatty liver in overweight and diabetic subjects: A twelve-week safety and efficacy study. Journal of Medicinal Food. 2020;23(9):905–919. doi:10.1089/jmf.2020.0075.
• Chatterji S, Fogel D. Study of the effect of the herbal composition SR2004 on hemoglobin A1c, fasting blood glucose, and lipids in patients with type 2 diabetes mellitus. Integrative Medicine Research. 2018;7(3):248-256. doi:10.1016/j.imr.2018.04.002.
• Araki R, Fujie K, Yuine N, et al. Olive leaf tea is beneficial for lipid metabolism in adults with prediabetes: An exploratory randomized controlled trial. Nutrition Research. 2019;67:60-66. doi:10.1016/j.nutres.2019.05.003.
• Phil RAM, Khan RA, Ashraf I. Effects of garlic on blood glucose levels and HbA1c in patients with type 2 diabetes mellitus. Journal of Medicinal Plants Research. 2011;5(13):2922-2928.
• Parham M, Bagherzadeh M, Asghari M, et al, Evaluating the effect of a herb on the control of blood glucose and insulin-resistance in patients with advanced type 2 diabetes (a double-blind clinical trial). Caspian Journal of Internal Medicine. 2020;11(1):12-26. doi:10.22088/cjim.11.1.12
• Mahluji S, Attari VE, Mobasseri M, et al. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. International Journal of Food Sciences and Nutrition. 2013;64(6):682-686. doi:10.3109/096377486.2013.775223.