Research Article
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Year 2022, , 540 - 547, 31.12.2022
https://doi.org/10.46519/ij3dptdi.1172937

Abstract

Supporting Institution

Karadeniz Technical University Scientific Research Project Coordination

Project Number

FYL-2020-8621.

Thanks

İpek Özpınar

References

  • 1. Navarro, M., Michiardi, A., Castano, O., Planell, J.A., “Biomaterials in orthopaedics”, J R Soc Interface, Vol. 5, Pages 1137–1158, 2008.
  • 2. Takahashi, Y., Yamamoto, M., Tabata Y., “Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and β-tricalcium phosphate”, Biomaterials, Vol. 26, Issue 17, Pages 3587–3596, 2005.
  • 3. Fu C., et al. “Antimicrobial silver-HAp composite coatings through two-stage electrochemical synthesis”, Surf Coat Technol, Vol. 301, Pages 13–19, 2016.
  • 4. Dorozhkin, SV., “Calcium orthophosphate deposits: preparation, properties and biomedical applications”. Mater Sci. Eng. C., Vol. 55, Pages 272–326, 2015.
  • 5. Akindoyo, J.O., Beg, M.D.H., Ghazali, S., Heim, H.P., Feldmann, M., “Effects of surface modification on dispersion, mechanical, thermal and dynamic mechanical properties of injection molded PLA-hydroxyapatite composites” Composites: Part A, Vol. 103, Pages 96-105, 2017.
  • 6. Sun, F., Zhou, H., Lee, J., “Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration”, Acta Biomater 2011, Vol. 7, Issue 11, Pages 3813–3828, 2011.
  • 7. Auras, R., Lim, L.T., Selk, S.E.M., Tsuji, H. “Polylactic Acid, Synthesis, Structures, Properties, Processing and Applications”, Wıley, NewYork, 2010.
  • 8. Wang, T., Chow, L.C., Frukhtbeyn, S.A., Ting, A.H., Dong, Q., Yang, M., Mitchell, J.W., “Improve the strength of PLA-HA composite through the use of surface initiated polymerization and phosphonic acid coupling agent”, Journal of Research of the National Institute of Standards and Technology, Vol. 116 Issue 5, Pages 785–796, 2011.
  • 9. Reverchon, E., Pisanti, P., Cardea, S., “Nanostructured pllahydroxyapatite scaffolds produced by a supercritical assisted technique”, Industrial and Engineering Chemistry Research, Vol.48, Issue 11, Pages 5310-5316, 2009.
  • 10. Talal, A., McKay, I., Tanner K., Hughes, F.J., “Effects of hydroxyapatite and PDGF concentrations on osteoblast growth in a nanohydroxyapatite-polylactic acid composite for guided tissue regeneration" Journal of Materials Science: Materials in Medicine, Vol. 24, Issue 9, Pages 2211-2221, 2013.
  • 11. Cui, Y., Liu, Y., Cui, Y., Jing, X., Zhang, P., Chen, X., “The nanocomposite scaffold of polylactide-co-glycolide and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair”, Acta Biomaterialia, Vol. 5 Issıe 7, Pages 2680–2692, 2009.
  • 12. Baird, D.G., “Polimer İşleme, Fiziksel Bilim ve Teknoloji Ansiklopedisi”, Üçüncü Baskı, 2003.
  • 13. Hoy, M.B., “3D printing: making things at the library”, Med. Ref. Serv. Q., Vol. 32, Pages, 94–99, 2013.
  • 14. Esposito, C.C., Gervaso, F., Scalera, F., Montagna, F., Maiullaro, T., Maffezzoli, S.A., “3D printing of hydroxyapatite polymer-based composites for bone tissue engineering”, J. Polym. Eng. Vol. 37, Pages 741–746, 2017.
  • 15. Youssef, A., Hollister, S.J., Dalton, P.D., “Additive manufacturing of polymer melts for implantable medical devices and scaffolds”, Biofabrication, Vol. 9, Pages 1-29, 2017.
  • 16. Wu, D., Spanou, A., Diez-Escuder, A., Persson, C., “3D-printed PLA HA composite structures as synthetic trabecular bone: A feasibility study using fused deposition modeling”, Journal of the mechanical behavior of biomedical materials, Vol. 103, Issue 103608, Pages 1-10, 2020.
  • 17. Rizzi, S.C., Heath, D., Coombes, A., Bock, N., Textor, M., Downes, S., “Biodegradable polymer hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts” J. Biomed. Mater. Res., Vol. 55, Pages 475 482, 2001.
  • 18. Wang, H., Li, Y., Zuo, Y., Li J., Ma, S., Cheng, L., “Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite polyamide composite scaffolds for bone tissue engineering”, Biomaterials, Vol. 28, Pages 3338–3348, 2007.
  • 19. Khoo, W., Nor, F.M., Ardhyananta, H., Kurniawan, D., “Preparation of Natural Hydroxyapatite from Bovine Femur Bones Using Calcination at Various Temperatures” 2nd. International Materials Industrial and Manufacturing Engineering Conference, MIMEC2015, Procedia Manufacturing, Vol. 2, Pages 196 – 201, 2015.
  • 20. Mahmud, K., Azharul Islam, M.D., Mitsionis, A., Albanis, T., Vaimakis, T., “Adsorption of direct yellow 27 from water by poorly crystalline hydroxyapatite prepared via precipitation method” Desalination and Water Treatment, Vol.41, Issue 1-3, Pages 170-178, 2012.
  • 21. Yee, Y.Y., Ching, Y.C., Rozali, S., Hashim, N.A., Singh, R. “Preparation and characterization of poly (lactic acid)-based composites reinforced with poly dimethyl siloxane/ultrasound-treated oil palm empty fruit bunch” Polymer Technology Engineering, Vol. 54, Issue 13, Pages 1321–33, 2015.
  • 22. Oguz, H., Dogan, C., Kara, D., Ozen, Z. T., Oavli, D. and Nofar, M., “Development of PLA-PBAT and PLA-PBSA bio-blends: Effects of processing type and PLA crystallinity on morphology and mechanical properties”, A.I.P. Conference Proceedings 2055, 030003 January 2019.

CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES

Year 2022, , 540 - 547, 31.12.2022
https://doi.org/10.46519/ij3dptdi.1172937

Abstract

Biomaterials are used in the treatment of advanced orthopedic diseases. Hydroxyapatite (HA), a bioceramic material, is important in the calcium phosphate family. Since hydroxyapatite exhibits low mechanical properties, it is used together with polylactic acid (PLA), which has biodegradable properties. In this study, HA was obtained by the combustion method and its morphological properties were analyzed by scanning electron microscope (SEM) and chemical analyzes by X-ray spectrometry. 3D mechanical test specimens were produced by the Fused Deposition Melting (FDM) technique using PLA-HA composite filaments by using the obtained HA as an additive material. Thermoplastic elastomer was used to examine the effect of compatibilizer in PLA and HA composite materials. Physical (SEM), thermal (thermogravimetric analysis, TGA), and mechanical properties (tensile and compression tests) of PLA-HA composite materials were investigated. According to the results obtained, TPE may have improved the chemical bonds that will form in PLA-HA composite materials. With the new bonds formed and the regular distribution of Hydroxyapatite, the interfacial bonds in PLA+HAP+TPE are better than the others and their thermal stability is more substantial. Due to this thermal stability, at least a percentage weight (70%) loss was seen in PLA+HAP+TPE. When the mechanical properties are examined, the tensile and compressive strength values of PLA+HAP+TPE composites are 29.2% and 12.5% higher than those of PLA+HAP composites, respectively.

Project Number

FYL-2020-8621.

References

  • 1. Navarro, M., Michiardi, A., Castano, O., Planell, J.A., “Biomaterials in orthopaedics”, J R Soc Interface, Vol. 5, Pages 1137–1158, 2008.
  • 2. Takahashi, Y., Yamamoto, M., Tabata Y., “Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and β-tricalcium phosphate”, Biomaterials, Vol. 26, Issue 17, Pages 3587–3596, 2005.
  • 3. Fu C., et al. “Antimicrobial silver-HAp composite coatings through two-stage electrochemical synthesis”, Surf Coat Technol, Vol. 301, Pages 13–19, 2016.
  • 4. Dorozhkin, SV., “Calcium orthophosphate deposits: preparation, properties and biomedical applications”. Mater Sci. Eng. C., Vol. 55, Pages 272–326, 2015.
  • 5. Akindoyo, J.O., Beg, M.D.H., Ghazali, S., Heim, H.P., Feldmann, M., “Effects of surface modification on dispersion, mechanical, thermal and dynamic mechanical properties of injection molded PLA-hydroxyapatite composites” Composites: Part A, Vol. 103, Pages 96-105, 2017.
  • 6. Sun, F., Zhou, H., Lee, J., “Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration”, Acta Biomater 2011, Vol. 7, Issue 11, Pages 3813–3828, 2011.
  • 7. Auras, R., Lim, L.T., Selk, S.E.M., Tsuji, H. “Polylactic Acid, Synthesis, Structures, Properties, Processing and Applications”, Wıley, NewYork, 2010.
  • 8. Wang, T., Chow, L.C., Frukhtbeyn, S.A., Ting, A.H., Dong, Q., Yang, M., Mitchell, J.W., “Improve the strength of PLA-HA composite through the use of surface initiated polymerization and phosphonic acid coupling agent”, Journal of Research of the National Institute of Standards and Technology, Vol. 116 Issue 5, Pages 785–796, 2011.
  • 9. Reverchon, E., Pisanti, P., Cardea, S., “Nanostructured pllahydroxyapatite scaffolds produced by a supercritical assisted technique”, Industrial and Engineering Chemistry Research, Vol.48, Issue 11, Pages 5310-5316, 2009.
  • 10. Talal, A., McKay, I., Tanner K., Hughes, F.J., “Effects of hydroxyapatite and PDGF concentrations on osteoblast growth in a nanohydroxyapatite-polylactic acid composite for guided tissue regeneration" Journal of Materials Science: Materials in Medicine, Vol. 24, Issue 9, Pages 2211-2221, 2013.
  • 11. Cui, Y., Liu, Y., Cui, Y., Jing, X., Zhang, P., Chen, X., “The nanocomposite scaffold of polylactide-co-glycolide and hydroxyapatite surface-grafted with l-lactic acid oligomer for bone repair”, Acta Biomaterialia, Vol. 5 Issıe 7, Pages 2680–2692, 2009.
  • 12. Baird, D.G., “Polimer İşleme, Fiziksel Bilim ve Teknoloji Ansiklopedisi”, Üçüncü Baskı, 2003.
  • 13. Hoy, M.B., “3D printing: making things at the library”, Med. Ref. Serv. Q., Vol. 32, Pages, 94–99, 2013.
  • 14. Esposito, C.C., Gervaso, F., Scalera, F., Montagna, F., Maiullaro, T., Maffezzoli, S.A., “3D printing of hydroxyapatite polymer-based composites for bone tissue engineering”, J. Polym. Eng. Vol. 37, Pages 741–746, 2017.
  • 15. Youssef, A., Hollister, S.J., Dalton, P.D., “Additive manufacturing of polymer melts for implantable medical devices and scaffolds”, Biofabrication, Vol. 9, Pages 1-29, 2017.
  • 16. Wu, D., Spanou, A., Diez-Escuder, A., Persson, C., “3D-printed PLA HA composite structures as synthetic trabecular bone: A feasibility study using fused deposition modeling”, Journal of the mechanical behavior of biomedical materials, Vol. 103, Issue 103608, Pages 1-10, 2020.
  • 17. Rizzi, S.C., Heath, D., Coombes, A., Bock, N., Textor, M., Downes, S., “Biodegradable polymer hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts” J. Biomed. Mater. Res., Vol. 55, Pages 475 482, 2001.
  • 18. Wang, H., Li, Y., Zuo, Y., Li J., Ma, S., Cheng, L., “Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite polyamide composite scaffolds for bone tissue engineering”, Biomaterials, Vol. 28, Pages 3338–3348, 2007.
  • 19. Khoo, W., Nor, F.M., Ardhyananta, H., Kurniawan, D., “Preparation of Natural Hydroxyapatite from Bovine Femur Bones Using Calcination at Various Temperatures” 2nd. International Materials Industrial and Manufacturing Engineering Conference, MIMEC2015, Procedia Manufacturing, Vol. 2, Pages 196 – 201, 2015.
  • 20. Mahmud, K., Azharul Islam, M.D., Mitsionis, A., Albanis, T., Vaimakis, T., “Adsorption of direct yellow 27 from water by poorly crystalline hydroxyapatite prepared via precipitation method” Desalination and Water Treatment, Vol.41, Issue 1-3, Pages 170-178, 2012.
  • 21. Yee, Y.Y., Ching, Y.C., Rozali, S., Hashim, N.A., Singh, R. “Preparation and characterization of poly (lactic acid)-based composites reinforced with poly dimethyl siloxane/ultrasound-treated oil palm empty fruit bunch” Polymer Technology Engineering, Vol. 54, Issue 13, Pages 1321–33, 2015.
  • 22. Oguz, H., Dogan, C., Kara, D., Ozen, Z. T., Oavli, D. and Nofar, M., “Development of PLA-PBAT and PLA-PBSA bio-blends: Effects of processing type and PLA crystallinity on morphology and mechanical properties”, A.I.P. Conference Proceedings 2055, 030003 January 2019.
There are 22 citations in total.

Details

Primary Language English
Subjects Biomaterial
Journal Section Research Article
Authors

Hatice Kübra Yerli This is me 0000-0003-4128-4188

Kutay Cava 0000-0002-3438-5418

Mustafa Aslan 0000-0003-2299-8417

Project Number FYL-2020-8621.
Publication Date December 31, 2022
Submission Date September 11, 2022
Published in Issue Year 2022

Cite

APA Yerli, H. K., Cava, K., & Aslan, M. (2022). CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES. International Journal of 3D Printing Technologies and Digital Industry, 6(3), 540-547. https://doi.org/10.46519/ij3dptdi.1172937
AMA Yerli HK, Cava K, Aslan M. CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES. IJ3DPTDI. December 2022;6(3):540-547. doi:10.46519/ij3dptdi.1172937
Chicago Yerli, Hatice Kübra, Kutay Cava, and Mustafa Aslan. “CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES”. International Journal of 3D Printing Technologies and Digital Industry 6, no. 3 (December 2022): 540-47. https://doi.org/10.46519/ij3dptdi.1172937.
EndNote Yerli HK, Cava K, Aslan M (December 1, 2022) CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES. International Journal of 3D Printing Technologies and Digital Industry 6 3 540–547.
IEEE H. K. Yerli, K. Cava, and M. Aslan, “CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES”, IJ3DPTDI, vol. 6, no. 3, pp. 540–547, 2022, doi: 10.46519/ij3dptdi.1172937.
ISNAD Yerli, Hatice Kübra et al. “CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES”. International Journal of 3D Printing Technologies and Digital Industry 6/3 (December 2022), 540-547. https://doi.org/10.46519/ij3dptdi.1172937.
JAMA Yerli HK, Cava K, Aslan M. CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES. IJ3DPTDI. 2022;6:540–547.
MLA Yerli, Hatice Kübra et al. “CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES”. International Journal of 3D Printing Technologies and Digital Industry, vol. 6, no. 3, 2022, pp. 540-7, doi:10.46519/ij3dptdi.1172937.
Vancouver Yerli HK, Cava K, Aslan M. CHARACTERISATION OF 3D PRINTED HYDROXYAPITATE POWDER (HAp) FILLED POLYLACTIC ACID (PLA) COMPOSITES. IJ3DPTDI. 2022;6(3):540-7.

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