Male reproductive system and autophagy

Abstract

To understand perfectly of programmed cell death mechanisms is quite important in determining the drugs and treatment approaches to be developed against diseases that may occur as a result of any disorder in these mechanisms. Recently, autophagy which is an interesting programmed death mechanism, has attracted the attention of scientists and was emphasized the need to clarify this mechanism. The male reproductive system is a complex system which keeps many molecular mechanisms and recently, it has been added to the literature that aims to demonstrate the effects and the underlying mechanisms of autophagy on spermatogenic cells, including spermatogenic stem cells, spermatogonium, spermatocytes and spermatozoa under physiological and pathophysiological conditions. In this study, we aimed to research the relationship between male reproductive system and autophagy mechanism.

Keywords

• autophagy,programmed cell dead,male reproductive system

Erkek üreme sistemi ve otofaji

Öz

Programlı hücre ölüm mekanizmalarını iyi anlamak, bu mekanizmalardaki herhangi bir bozukluk sonucu oluşabilecek hastalıklara karşı geliştirilecek ilaçlar ve tedavi yaklaşımlarını belirlemede oldukça önemlidir. Son dönemlere ilgi çekici bir programlı ölüm mekanizması olan otofaji bilim insanlarının dikkatini çekmiş ve bu mekanizmanın aydınlatılması gerekliliği vurgulanmıştır. Erkek üreme sistemi birçok moleküler mekanizmayı barındıran komplike bir sistemdir ve son dönemde, spermatogenik kök hücreler, spermatogonium, spermatosit ve spermatozoa dahil olmak üzere, spermatogenik hücreler üzerindeki otofajinin etkilerini ve altta yatan mekanizmalarını fizyolojik ve patofizyolojik koşullar altında göstermeyi hedefleyen çalışmalarda literatüre eklenmektedir. Bizde bu çalışma ile erkek üreme sistemi ve otofaji mekanizması arasındaki ilişkiyi incelemeyi amaçladık.

Anahtar Kelimeler

• erkek üreme sistemi,otofaji,programlı hücre ölümü

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