Male reproductive system and autophagy

Abstract

To understand perfectly of programmed cell death mechanisms is quite important in determining the drugs and treatment approaches to be developed against diseases that may occur as a result of any disorder in these mechanisms. Recently, autophagy which is an interesting programmed death mechanism, has attracted the attention of scientists and was emphasized the need to clarify this mechanism. The male reproductive system is a complex system which keeps many molecular mechanisms and recently, it has been added to the literature that aims to demonstrate the effects and the underlying mechanisms of autophagy on spermatogenic cells, including spermatogenic stem cells, spermatogonium, spermatocytes and spermatozoa under physiological and pathophysiological conditions. In this study, we aimed to research the relationship between male reproductive system and autophagy mechanism.

Keywords

• autophagy,programmed cell dead,male reproductive system

Erkek üreme sistemi ve otofaji

Öz

Programlı hücre ölüm mekanizmalarını iyi anlamak, bu mekanizmalardaki herhangi bir bozukluk sonucu oluşabilecek hastalıklara karşı geliştirilecek ilaçlar ve tedavi yaklaşımlarını belirlemede oldukça önemlidir. Son dönemlere ilgi çekici bir programlı ölüm mekanizması olan otofaji bilim insanlarının dikkatini çekmiş ve bu mekanizmanın aydınlatılması gerekliliği vurgulanmıştır. Erkek üreme sistemi birçok moleküler mekanizmayı barındıran komplike bir sistemdir ve son dönemde, spermatogenik kök hücreler, spermatogonium, spermatosit ve spermatozoa dahil olmak üzere, spermatogenik hücreler üzerindeki otofajinin etkilerini ve altta yatan mekanizmalarını fizyolojik ve patofizyolojik koşullar altında göstermeyi hedefleyen çalışmalarda literatüre eklenmektedir. Bizde bu çalışma ile erkek üreme sistemi ve otofaji mekanizması arasındaki ilişkiyi incelemeyi amaçladık.

Anahtar Kelimeler

• erkek üreme sistemi,otofaji,programlı hücre ölümü

Kaynakça

1. 1. Eskandari M, Ghalyanchi Langeroudi A, Zeighami H, Rostami A, Kazemi M, Eyni H, Shokri S. Co-administration of ginseng and ciprofloxacin ameliorates epididymo orchitis induced alterations in sperm quality and spermatogenic cells apoptosis following infection in rats. Andrologia 2017; 49-3.
2. 2. Lin CY, Chen CY, Yu CH, Yu IS, Lin SR, Wu JT, Lin YH, Kuo PL, Wu JC, Lin SW. Human X-linked intellectual disability factor CUL4B is required for post-meiotic sperm development and male fertility. Sci Rep 2016; 6: 1-17.
3. 3. Powell MJ, Casimiro MC, Cordon-Cardo C, He X, Yeow WS, Wang C, McCue PA, McBurney MW, Pestell RG. Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation. Cancer Res 2011;71: 964–75.
4. 4. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2001; 2: 211-6.
5. 5. İzmirli M, Ecevit H, Göğebakan B. Autophagy to Survive, Archives Medical Review Journal. 2014; 23: 411-9
6. 6. Ross HM, Pawlina W. Histoloji Konu Anlatımı ve Atlas İlişkili Hücre Biyolojisi ve Moleküler Biyoloji ile Çeviri Editörü: Barış Baykal 6. baskı. 2014: 784-809.
7. 7. Kierszenbaum AL. Histoloji ve Hücre Biyolojisi Patolojiye Giriş, Palme Yayıncılık, Ankara 2006; 1: 672-683.
8. 8. Griswold MD. Spermatogenesis: the commitment to meiosis. Physiol Rev 2016; 96-117.

9. 9. Chen Y, Klionsky DJ. The regulation of autophagy - unanswered questions. Journal of Cell Science 2011 124: 161-70.
10. 10. Endo T, Romer KA, Anderson EL, Baltus AE, de Rooij DG, Page DC. Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis. Proc Natl Acad Sci USA 2015; 112: 2347-56.
11. 11. Smith LB. Nonclassical testosterone signaling: a new pathway controlling spermatogenesis? Biol Reprod 2016; 1-2.
12. 12. Aparicio IM, Espino J, Bejarano I, Gallardo-Soler A, Campo ML, Salido GM, Pariente JA, Peña FJ, Tapia JA. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Scientific Reports 2016; 6: 33647-54.
13. 13. Komatsu M, Waguri S, Koike M, Warabi E, Uwayama T, Ezaki J, Ueno T, Hara T, Sou Y. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007; 14: 1149-63.
14. 14. Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Mazure MN. Hypoxia-induced autophagy is mediated through Hypoxia-Inducible Factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell Biol. 2009; 29: 2570-81.
15. 15. Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ. 2008; 15: 171-82.
16. 16. Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptaion. Nat Cell Biol 2007; 9: 1102-9.
17. 17. Arslan DÖ, Korkmaz G, Gözüaçık D. Otofaji: Bir Hücresel Stres Yanıtı ve Ölüm Mekanizması. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 2011, 2: 184-94.
18. 18. Zhang M, Jiang M, Bi Y, Zhu H, Zhou Z, Sha J. Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice. Plos One.2012; 7: 7.
19. 19. Gallagher LE, Williamson LE, Chan EY. Advances in autophagy regulatory mechanisms. Cells 2016; 5: 1–30.
20. 20. Liu ML, Wang JL, Wei J, Xu LL, Yu M, Liu XM, Ruan WL, Chen JX. Tri-ortho-cresyl phosphate induces autophagy of rat spermatogonial stem cells. Reproduction 2015; 149:163-70.
21. 21. Xu LL, Liu ML, Wang JL, Yu M, Chen JX. Saligenin cyclic-o-tolyl phosphate (SCOTP) induces autophagy of rat spermatogonial stem cells. Reprod Toxicol 2016; 60: 62–8.
22. 22. Mancilla H, Maldonado R, Cereceda K, Villarroel-Espindola F, Montes de Oca M, Angulo C, Castro MA, Slebe JC, Vera JC, Lavandero S, Concha II. Glutathione depletion induces spermatogonial cell autophagy. J Cell Biochem 2015; 116: 2283–92.
23. 23. Liu K, Zhang G, Wang Z, Liu Y, Dong J, Dong X, Liu J, Cao J, Ao L, Zhang S. The protective effect of autophagy on mouse spermatocyte derived cells exposure to 1800MHz radiofrequency electromagnetic radiation. Toxicol Lett 2014; 228: 216-22.
24. 24. Li L, Chen Y, Gibson SB. Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation. Cellular Sign. 2013; 25: 50-65.
25. 25. Li Z, Li Y, Zhou X, Dai P, Li C. Autophagy involved in the activation of the Nrf2-antioxidant system in testes of heat-exposed mice. Journal of Thermal Bio. 2018; 71: 142-52.