Biorisks Associated with Synthetic Biology: Virulence plasmid Transfer to Probiotic or Starter Cultures

Year 2024, , 120 - 132, 15.08.2024

Ahmet Koluman , Mahmed Sari Njjar , Fatma Altıntaş , Atakan Konukbay

https://doi.org/10.38001/ijlsb.1426971

Abstract

Synthetic biology has revolutionized the field of biotechnology, enabling precise manipulation of biological systems for diverse applications. While the advancements in this rapidly evolving field are promising, there is a growing concern about potential biorisks associated with synthetic biology techniques. One significant risk is the transfer of pathogenic plasmids to probiotic or starter cultures, which could lead to unintended consequences and pose serious threats to human health. This paper reviews the biorisks of pathogenic plasmid transfer, discusses potential consequences, and proposes risk mitigation strategies to ensure responsible and safe use of synthetic biology in probiotics and starter cultures.

Keywords

Synthetic Biology, Biorisks, Probiotic, Pathogenic Plasmid

Sentetik Biyoloji ile İlişkili Biyoriskler: Probiyotik veya Starter Kültürlere Virülans Plazmid Transferi

Abstract

Sentetik biyoloji, çeşitli uygulamalar için biyolojik sistemlerin hassas bir şekilde manipüle edilmesini sağlayarak biyoteknoloji alanında devrim yaratmıştır. Hızla gelişen bu alandaki ilerlemeler umut verici olsa da, sentetik biyoloji teknikleriyle ilişkili potansiyel biyoriskler hakkında artan bir endişe bulunmaktadır. Önemli risklerden biri, patojenik plazmidlerin probiyotik veya starter kültürlere aktarılmasıdır; bu da istenmeyen sonuçlara yol açabilir ve insan sağlığı için ciddi tehditler oluşturabilmektedir. Bu makale, patojenik plazmid transferinin biyorisklerini gözden geçirmekte, potansiyel sonuçları tartışmakta ve probiyotiklerde ve starter kültürlerde sentetik biyolojinin sorumlu ve güvenli bir şekilde kullanılmasını sağlamak için risk azaltma stratejileri önermektedir.

Keywords

Sentetik Biyoloji, Bioriskler, Probiyotik, Patojenik Plazmid

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