Research Article
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Year 2020, , 317 - 324, 15.12.2020
https://doi.org/10.38001/ijlsb.741158

Abstract

References

  • Grüngreiff, K., Reinhold, D. and Wedemeyer, H. The role of zinc in liver cirrhosis. Annals Hepatology. 2016. 15 (1): 7-16.
  • Leoni, G., Rosato, A. and Perozzi, G. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutrition. 2014. 9: 436.
  • Rink, L. and Haase, H. Zinc homeostasis and immunity. Trends Immunololgy. 2007. 28: 1-4.
  • Brown, K. H. and Wuehler, S. E. Zinc and Human Health: The Results of Recent Trials and Implications for Program Interventions and Research, Ottawa: Micronutrient Init. 2000. page 1-69.
  • Stockham, S. L., and Scott, M. A. Fundamentals of veterinary clinical pathology. 2008. 2nd ed. Ames (IA): Blackwell Publishing, Iowa, USA.
  • Talpur, M., Shaikh, S., Shah, S. A., Memon, A. R., and Khoharo H. K. Zinc Sulphate in Azathioprine induced Hepatotoxicity-An Experimental Study. World Journal of Biological and Medical Science. 2014. 1(4); 72-80.
  • Mohamed, E. T., Said, A. I.Samer, A. and El-sayed. Protective effect of zinc aspartate against acetaminophen induced hepato-renal toxicity in albino rats. Journal of Radiation Research and Applied Science. 2011. Vol. 4, No. 2(B), pp. 709 – 723.
  • Ashafa, A. O. T., Yakubu M. T., Grierson, D. S. and Afolayan, A. J. Toxicological evaluation of the aqueous extract of Felicia muricata thumb leaves in wistar rats. African Journal of Biotechnology. 2009. 8(6): 949-954.
  • Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem. Pharmacological Mag. 2007. 3:34.
  • Salehi, B., Martorell, M., Arbiser, J. L., Sureda,A., Martins N., Maurya,P. K., Sharifi-Rad,M., Kumar,P. and Sharifi-Rad, J. Antioxidants: Positive or Negative Actors?. Biomolecule.2018. 8: pp 124.
  • Nielsen, F., Mikkelsen, B.B., Nielsen, J.B., Andersen, H.R., Grandjean, P. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clinical Chemistry. 1997. 43, 1209–1214.
  • Mahmoud, Y.N., Salem, A. Z. and El-Moslemany M. A. Nephroprotective and Antioxidant Effects of Parsley Plant Parts AgainstGentamicin-Induced Nephrotoxicity in Rats. Academic Journal of Nutrition. 2015. 4 (3): 113-122.
  • Olorunfemi, A. E., Arit, E., Iboro, I., and Ahnold, C. I. Biochemical changes in serum of rat treated with aqueous extract of the fruit of Telferiaoccidentalis. African Journal of Biomedical Research. 2006. 9(2): 235-237.
  • Hosseini-Vashan, S.J., Golian, A., and Yaghobfar, A., Effects of turmeric rhizome powder and source of oil in diet on blood metabolites, immune system and antioxidant sta-tus in heat stressed broiler chickens. Journal of Livestock Science and Technology. 2015. 3, 13-20.
  • Fathi, M., Haydari, M. and Tanha, T. Effects of zinc oxide nanoparticles on antioxidant status, serum enzymes activities, biochemical parameters and performance in broiler chickens. Journal of Livestock Science and Technology. 2016. 4 (2): 07-13.
  • Luck H. Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press. 1971. Ohkawa, H., Ohisshi, N., and Yagi, K. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochemistry. 1979. 95:351-8.
  • NHANES. Biochemical profile in refrigerated serum: Laboratory procedure manual. 2000.
  • Seyyed, A. M., Ghaidateh, A., Mahin, D. and Esrafil, M. The effects of zinc sulphate on miR-34a, antioxidants, biochemical and histopathological parameters following ischemia/Reperfusion injury in rats. Biological Trace Element Research. 2018. 1 (2); pp 1425-1428.
  • Palmer, B. F. Regulation of potassium homeostasis. Clinical Journal of Nephrolology. 2015. 10: 1050-1060. Prasad, A. S. Clinical, immunological, anti-inflamma-tory and antioxidant roles of zinc. Experimental Gerontolology. 2008. 43,370–377.
  • Ozturk, O. and Gumuslu, S. Changes in glucose-6-phos-phate dehydrogenase, copper, zinc-superoxide dismutase and catalase activities glutathione and its metabolizing en-zymes, and lipid peroxidation in rat erythrocytes with age. Experimental Gerontolology. 2004. 39, 211–216.
  • Zhao, C.Y., Tan, S. X., Xiao, X. Y., Qiu, S. X., Pan, J. Q. and Tang, Z. X. Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers. Biological Trace Element Research. 2014. 160, 361–367.
  • Binukumar, B.K., Bal, A., Sunkaria, A. and Gill, K. D. Mitochondrial energy metabolism impairment and liver dysfunction following exposure to dichlorvos. Toxicology. 2010. 270(2-3), 77-84.

Short term effect of zinc administration on some biochemical parameters and antioxidant enzymes in albino rats

Year 2020, , 317 - 324, 15.12.2020
https://doi.org/10.38001/ijlsb.741158

Abstract

Zinc is an essential trace element exerting important antioxidant, anti-inflammatory, and apoptotic effects, and is capable of influencing molecular functioin as well as signal transduction. It is used as a supplement for the treatment of diarrhoea. This study was conceived to evaluate the short term effect of zinc administration on some biochemical parameters and antioxidant enzymes in albino rats. Sixteen (16) albino rats (both sexes) were allocated randomly into four experimental groups of four rats each. One group served as the control and were given distilled water. The three experimental groups were administered with 10, 20 and 40 mg/kg body weight of Zn respectively for 14 consecutive days. The animals were sacrificed on the 15th day and blood was collected for liver and kidney function parameters, antioxidant enzymes activities and malondialdehyde concentration using standard procedures. The concentrations of alkaline phosphatase (ALP) and alanine aminotransferase (ALT) significantly increase (p < 0.05) while aspartate transferase (AST) significantly decreased in a dose dependent manner when compared with the control group. There was a significant decrease (p < 0.05) in creatinine, a significant increase in potassium and no significant difference in serum urea level when compared with the control group. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase significantly increased while MDA significantly decreased when compared with the control group. Increase in ALT suggests an improvement in the activities of these enzymes while increased potassium level is an indication of kidney dysfunction. Increased antioxidant enzymes and decreased MDA may suggest that zinc improved antioxidant status and decrease free radical generation. From the study, it may be suggested that zinc improved the activities of liver biomakers and antioxidant enzymes. It is therefore recommended that more studies be carried out in establishing the effect of zinc for prolonged usage, at larger doses on other organs.

References

  • Grüngreiff, K., Reinhold, D. and Wedemeyer, H. The role of zinc in liver cirrhosis. Annals Hepatology. 2016. 15 (1): 7-16.
  • Leoni, G., Rosato, A. and Perozzi, G. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutrition. 2014. 9: 436.
  • Rink, L. and Haase, H. Zinc homeostasis and immunity. Trends Immunololgy. 2007. 28: 1-4.
  • Brown, K. H. and Wuehler, S. E. Zinc and Human Health: The Results of Recent Trials and Implications for Program Interventions and Research, Ottawa: Micronutrient Init. 2000. page 1-69.
  • Stockham, S. L., and Scott, M. A. Fundamentals of veterinary clinical pathology. 2008. 2nd ed. Ames (IA): Blackwell Publishing, Iowa, USA.
  • Talpur, M., Shaikh, S., Shah, S. A., Memon, A. R., and Khoharo H. K. Zinc Sulphate in Azathioprine induced Hepatotoxicity-An Experimental Study. World Journal of Biological and Medical Science. 2014. 1(4); 72-80.
  • Mohamed, E. T., Said, A. I.Samer, A. and El-sayed. Protective effect of zinc aspartate against acetaminophen induced hepato-renal toxicity in albino rats. Journal of Radiation Research and Applied Science. 2011. Vol. 4, No. 2(B), pp. 709 – 723.
  • Ashafa, A. O. T., Yakubu M. T., Grierson, D. S. and Afolayan, A. J. Toxicological evaluation of the aqueous extract of Felicia muricata thumb leaves in wistar rats. African Journal of Biotechnology. 2009. 8(6): 949-954.
  • Yakubu, M. T., Akanji, M. A. and Oladiji, A. T. Haematological evaluation in male albino rats following chronic administration of aqueous extract of Fadogia agrestis stem. Pharmacological Mag. 2007. 3:34.
  • Salehi, B., Martorell, M., Arbiser, J. L., Sureda,A., Martins N., Maurya,P. K., Sharifi-Rad,M., Kumar,P. and Sharifi-Rad, J. Antioxidants: Positive or Negative Actors?. Biomolecule.2018. 8: pp 124.
  • Nielsen, F., Mikkelsen, B.B., Nielsen, J.B., Andersen, H.R., Grandjean, P. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clinical Chemistry. 1997. 43, 1209–1214.
  • Mahmoud, Y.N., Salem, A. Z. and El-Moslemany M. A. Nephroprotective and Antioxidant Effects of Parsley Plant Parts AgainstGentamicin-Induced Nephrotoxicity in Rats. Academic Journal of Nutrition. 2015. 4 (3): 113-122.
  • Olorunfemi, A. E., Arit, E., Iboro, I., and Ahnold, C. I. Biochemical changes in serum of rat treated with aqueous extract of the fruit of Telferiaoccidentalis. African Journal of Biomedical Research. 2006. 9(2): 235-237.
  • Hosseini-Vashan, S.J., Golian, A., and Yaghobfar, A., Effects of turmeric rhizome powder and source of oil in diet on blood metabolites, immune system and antioxidant sta-tus in heat stressed broiler chickens. Journal of Livestock Science and Technology. 2015. 3, 13-20.
  • Fathi, M., Haydari, M. and Tanha, T. Effects of zinc oxide nanoparticles on antioxidant status, serum enzymes activities, biochemical parameters and performance in broiler chickens. Journal of Livestock Science and Technology. 2016. 4 (2): 07-13.
  • Luck H. Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press. 1971. Ohkawa, H., Ohisshi, N., and Yagi, K. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochemistry. 1979. 95:351-8.
  • NHANES. Biochemical profile in refrigerated serum: Laboratory procedure manual. 2000.
  • Seyyed, A. M., Ghaidateh, A., Mahin, D. and Esrafil, M. The effects of zinc sulphate on miR-34a, antioxidants, biochemical and histopathological parameters following ischemia/Reperfusion injury in rats. Biological Trace Element Research. 2018. 1 (2); pp 1425-1428.
  • Palmer, B. F. Regulation of potassium homeostasis. Clinical Journal of Nephrolology. 2015. 10: 1050-1060. Prasad, A. S. Clinical, immunological, anti-inflamma-tory and antioxidant roles of zinc. Experimental Gerontolology. 2008. 43,370–377.
  • Ozturk, O. and Gumuslu, S. Changes in glucose-6-phos-phate dehydrogenase, copper, zinc-superoxide dismutase and catalase activities glutathione and its metabolizing en-zymes, and lipid peroxidation in rat erythrocytes with age. Experimental Gerontolology. 2004. 39, 211–216.
  • Zhao, C.Y., Tan, S. X., Xiao, X. Y., Qiu, S. X., Pan, J. Q. and Tang, Z. X. Effects of dietary zinc oxide nanoparticles on growth performance and antioxidative status in broilers. Biological Trace Element Research. 2014. 160, 361–367.
  • Binukumar, B.K., Bal, A., Sunkaria, A. and Gill, K. D. Mitochondrial energy metabolism impairment and liver dysfunction following exposure to dichlorvos. Toxicology. 2010. 270(2-3), 77-84.
There are 22 citations in total.

Details

Primary Language English
Subjects Biochemistry and Cell Biology (Other)
Journal Section Research Articles
Authors

Yusuf Jacob Akure 0000-0002-5213-9886

Maryam Ahmed 0000-0002-4061-0183

Hyelni Bukar 0000-0001-7342-227X

Gingsami Simon This is me 0000-0002-9201-2599

Publication Date December 15, 2020
Published in Issue Year 2020

Cite

EndNote Jacob Akure Y, Ahmed M, Bukar H, Simon G (December 1, 2020) Short term effect of zinc administration on some biochemical parameters and antioxidant enzymes in albino rats. International Journal of Life Sciences and Biotechnology 3 3 317–324.


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