Phytochemical screening and in vitro evaluation of the antiarthritic activity of Nigella sativa L. seeds extracts

Year 2021, , 381 - 388, 15.12.2021

Mohammed Cheurfa , Abdalbasit Marıod , Kaddour Yahya , Benmbarek İslam

https://doi.org/10.38001/ijlsb.868282

Abstract

The objective of this study was the evaluation of the antiarthritic activity as well as the phytochemical screening of Nigella sativa L. seeds extracts in vitro. The dosage of flavonoids have shown that the content found in the hydroalcoholic extract (134.7 ± 0.289 mg QE / g) was significantly higher compared to the aqueous extract (48.495 ± 0.035mg QE / g). The phytochemicals analysis of the extracts revealed the presence of tannins, saponins and reducing compounds and the absence of alkaloids. The results of antiarthritic activity showed an important effect of the aqueous and hydroalcoholic extracts on the inhibition of inflammation.The results of this study show that the seed extracts exhibited an important anti-inflammatory effect.

Keywords

Nigella Sativa L,, Aqueous extract,, Hydroalcoholic extract,, Antiarthritic activity, Inflammation

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