Review on Nanoformulations of Curcumin (Curcuma longa Linn.): Special Emphasis on Nanocurcumin®

Year 2019, Volume: 3 Issue: 1, 1 - 12, 01.06.2019

Aminul Islam Leroy Rebello Sreesudha Chepyala

Abstract

The
three major diphenolic, hydrobhobic orange coloured compounds derived from the
rhizome of Curcuma longa Linn.
(turmeric) of Zingiberaceae family, namely diferuloylmethane, demethoxycurcumin
and bisdemethoxycurcumin has been exhibited several pharmacological efficacies
both in preclinical and clinical studies through its anti-inflammatory,
anti-microbial, anticancer and anti-Alzheimer properties. Furthermore, these
curcuminoids were also showed hepatoprotective, nephroprotective,
neuroprotective, cardioprotective, hypoglycaemic activities. Researchers were
also observed the antioxidant properties of these novel compounds in a
significant level. Therefore, all the curcuminoids were considered as an
important bioactive molecule in the natural product market and herbal industry.
Despite being a robust pharmacologically active agent, all the three
curcuminoids were exhibited very poor solubility in water and therefore the
systemic bioavailability were also very low, which attributed very poor
absorption, faster metabolism and systemic elimination after oral
administration. Consequently, its therapeutic actions were also diminished in a
significant percentage. In this scenario researchers have been designed and
developed several nanotechnological delivery system for curcuminoids to
overcome this limitation. Here, in this article, we have summarized the various
methods of nanocurcumin including polymeric nanoparticles and micelles,
liposomes, cyclodextrins, solid dispersions, peptide carriers, lipid nanoparticles
and emulsions. 

Keywords

Nanocurcumin, nanotechnology, nanoparticle, solubility, bioavailability, pharmacological activity

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