Review
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Year 2019, Volume 3, Issue 1, 1 - 12, 01.06.2019

Abstract

References

  • 1. Vogel, H.A., Pelletier, J., 1815. Curcumin-biological and medicinal properties. Journal of Pharmacology, 2, 50-50.2. Milobedzka, J., Kostanecki, V., Lampe, V., 1910. Structure of curcumin. Berichte der Deutschen Chemischen Gesellschaft, 43, 2163-2170. 3. Roughley, P.J., Whiting, D.A., 1973. Experiments in the biosynthesis of curcumin. Journal of Chemical Society, Perkin Transactions 1, 20, 2379-2388.4. Payton, F., Sandusky, P., Alworth, W.L., 2007. NMR study of the solution structure of curcumin. Journal of Natural Products, 70, 143-146.5. Basnet, P., Tho, I., Skalko-Basnet, N., 2010. Curcumin, A Wonder Drug of 21st Century: Liposomal Delivery System Targeting Vaginal Inflammation. 5th International Congress on Complementary Medicine Research, Tromsø, Norway, May 19–21, Abstract Number A9M2K9C.6. Jovanovic, S.V., Steenken, S., Boone, C.W., Simic, M.G., 1999. H-atom transfer is a preferred antioxidant mechanism of curcumin. Journal of American Chemical Society, 121, 9677-9681.7. Aggarwal, B, B., Harikumar, K.B., 2009. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemical Cell Biol, 41, 40–59.8. Chattopadhyay, I., Biswas, K., Bandyopadhyay, U., Banerjee, R.K., 2004. Turmeric and curcumin: biological actions and medicinal applications. Current Science, 87, 44-53.9. Maheshwari, RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sciences, 2006; 78:2081-7.10. Sandur, S.K., Pandey, M.K., Sung, B., Ahn, K.S., Murakami, A., Sethi, G., et al., 2007. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis, 28, 1765-73.11. Rupareli, J.P., Chatterjee, A.K., Duttagupta, S.P., Mukherji, S., 2008. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomaterialia, 4(3), 707-716. 12. Wang, A.Z., Langer, R., Farokhzad, O.C., 2012. Nanoparticle delivery of cancer drugs.Annual Review of Medicine, 63, 185-198. 13. Cridge, B.J., Larsen, L., Rosengren, R.J., 2013. Curcumin and its derivatives in breast cancer: Current developments and potential for the treatment of drug-resistant cancers. Oncology Discovery, 2052, 1-6.14. Carey, L., Winer, E., Viale, G., Cameron, D., Gianni, L., 2010. Triple-negative breast cancer: disease entity or title of convenience?. Nature Reviews Clinical Oncology, 7(12), 683-692.15. Yallapu, M.M., Othman, S.F., Curtis, E.T., Bauer, N.A., Chauhan, N., Kumar, D., Jaggi, M., Chauhan, S.C., 2012. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. International Journal of Nanomedicine, 7, 1761-1779.16. Lin, W., Cooper, C., Camarillo, I., 2014 June 17-19. The effectiveness of electroporation-based nanocurcumin and curcumin treatments on human breast cancer cells. In: Proceedings of ESA annual meeting on electrostatics, University of Notre Dame, Notre Dame, Indiana., USA, Electrostatics Society of America, 1-7. 17. Ganta, S., Amiji, M., 2009. Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Molecular Pharmaceutics, 6(3), 928-939.18. Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N., Hong, S.M., Pramanik, D., Chenna, V., Karikari, C., Sharma, R., Goggins, M.G., Rudek, M.A., Ravi, R., Maitra, A., Maitra, A., 2010. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Molecular Cancer Therapeutics, 9(8), 2255-2264. 19. Yallapu, M.M., Ebeling, M.C., Khan, S., Sundram, V., Chauhan, N., Gupta, B.K., Puumala, S.E., Jaggi, M., Chauhan, S.C., 2013. Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. Molecular Cancer Therapy, 12(8), 1471-1480. 20. Ruddon, R.W., 2007. Cancer biology, 4th ed. Oxford University Press, Oxford, 223. 21. Yallapu, M.M., Khan, S., Maher, D.M., Ebeling, M.C., Sundram, V., Chauhan. N., Ganju, A., Balakrishna, S., Gupta, B.K., Zafar, N., Jaggi, M., Chauhan, S.C., 2014. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials, 35(30), 8635-8648. 22. Gopal, J., Muthu, M., Chun, S., 2016. Bactericidal Property of Macro-, Micro- and Nanocurcumin: An Assessment. Arabian Journal Science and Engineering, 41(6),2087–2093.23. Bhawana., Basniwal, R.K., Buttar, H.S., et al. 2011. Curcumin nanoparticles: preparation, characterization, and antimicrobial study. Journal of Agriculture and Food Chemistry, 259(5), 2056–2061.24. Vimala, K., Mohan, Y.M., Varaprasad, K., et al. 2011. Fabrication of Curcumin Encapsulated Chitosan-PVA Silver Nanocomposite Films for Improved Antimicrobial Activity. Journal of Biomaterials and Nanobiotechnology, 2(1), 55–64.25. Gandapu, U., Chaitanya, R.K., Kishore, G., Reddy, R.C., Kondapi, A. K., 2011. Curcumin-Loaded Apotransferrin Nanoparticles Provide Efficient Cellular Uptake and Effectively Inhibit HIV-1 Replication In-Vitro. PLoS One, 6(8), e23388. 26. Akhtar, F., Rizvi, M.M., Kar, S.K., 2012. Biotechnological Advances, 30(1), 310-320. 27. Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., & Diederich, M., 2005. Chemopreventive and therapeutic effects of curcumin. Cancer letters, 223(2), 181-190.28. Luthra, P. M., Singh, R., Chandra, R., 2001. Therapeutic uses of Curcuma longa (turmeric). Indian Journal of Clinical Biochemistry, 16(2), 153-160.29. Singh, A.K., Vinayak, M., 2015. Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-α, IL-1β and IL-6. Neurochemical Research, 40, 463-72.30. Rocha, B.A., Gonçalves, O.H., Leimann, F.V., Rebecca, E.S.W., Silva-Buzanello, R.A., Filho, L.C., Araújo, P.H.H., Cuman, R.K.N., Bersani-Amado, C., A., 2014. Curcumin encapsulated in poly-L-lactic acid improves its anti-inflammatory efficacy in vivo. Advancement in Medicinal Plant Research, 2(4), 62-73.31. Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., Zhang, H.G., 2010. A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes, The American Society of Gene & Cell Therapy, Molecular Therapy, 18(9), 1606-1614.32. Cheng, K.K., Yeung, C.F., Ho, S.W., Chow, S.F., Chow, A.H., Baum, L., 2013. Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood-Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice, American Association of Pharmaceutical Scientists Journal, 15(2), 324-336. 33. Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., Maekawa, T., Venugopal, K., Kumar, D.S., 2012. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease., PLoS One, 7(3), e32616.

Review on Nanoformulations of Curcumin (Curcuma longa Linn.): Special Emphasis on Nanocurcumin®

Year 2019, Volume 3, Issue 1, 1 - 12, 01.06.2019

Abstract

The three major diphenolic, hydrobhobic orange coloured compounds derived from the rhizome of Curcuma longa Linn. (turmeric) of Zingiberaceae family, namely diferuloylmethane, demethoxycurcumin and bisdemethoxycurcumin has been exhibited several pharmacological efficacies both in preclinical and clinical studies through its anti-inflammatory, anti-microbial, anticancer and anti-Alzheimer properties. Furthermore, these curcuminoids were also showed hepatoprotective, nephroprotective, neuroprotective, cardioprotective, hypoglycaemic activities. Researchers were also observed the antioxidant properties of these novel compounds in a significant level. Therefore, all the curcuminoids were considered as an important bioactive molecule in the natural product market and herbal industry. Despite being a robust pharmacologically active agent, all the three curcuminoids were exhibited very poor solubility in water and therefore the systemic bioavailability were also very low, which attributed very poor absorption, faster metabolism and systemic elimination after oral administration. Consequently, its therapeutic actions were also diminished in a significant percentage. In this scenario researchers have been designed and developed several nanotechnological delivery system for curcuminoids to overcome this limitation. Here, in this article, we have summarized the various methods of nanocurcumin including polymeric nanoparticles and micelles, liposomes, cyclodextrins, solid dispersions, peptide carriers, lipid nanoparticles and emulsions. 

References

  • 1. Vogel, H.A., Pelletier, J., 1815. Curcumin-biological and medicinal properties. Journal of Pharmacology, 2, 50-50.2. Milobedzka, J., Kostanecki, V., Lampe, V., 1910. Structure of curcumin. Berichte der Deutschen Chemischen Gesellschaft, 43, 2163-2170. 3. Roughley, P.J., Whiting, D.A., 1973. Experiments in the biosynthesis of curcumin. Journal of Chemical Society, Perkin Transactions 1, 20, 2379-2388.4. Payton, F., Sandusky, P., Alworth, W.L., 2007. NMR study of the solution structure of curcumin. Journal of Natural Products, 70, 143-146.5. Basnet, P., Tho, I., Skalko-Basnet, N., 2010. Curcumin, A Wonder Drug of 21st Century: Liposomal Delivery System Targeting Vaginal Inflammation. 5th International Congress on Complementary Medicine Research, Tromsø, Norway, May 19–21, Abstract Number A9M2K9C.6. Jovanovic, S.V., Steenken, S., Boone, C.W., Simic, M.G., 1999. H-atom transfer is a preferred antioxidant mechanism of curcumin. Journal of American Chemical Society, 121, 9677-9681.7. Aggarwal, B, B., Harikumar, K.B., 2009. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. International Journal of Biochemical Cell Biol, 41, 40–59.8. Chattopadhyay, I., Biswas, K., Bandyopadhyay, U., Banerjee, R.K., 2004. Turmeric and curcumin: biological actions and medicinal applications. Current Science, 87, 44-53.9. Maheshwari, RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sciences, 2006; 78:2081-7.10. Sandur, S.K., Pandey, M.K., Sung, B., Ahn, K.S., Murakami, A., Sethi, G., et al., 2007. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis, 28, 1765-73.11. Rupareli, J.P., Chatterjee, A.K., Duttagupta, S.P., Mukherji, S., 2008. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomaterialia, 4(3), 707-716. 12. Wang, A.Z., Langer, R., Farokhzad, O.C., 2012. Nanoparticle delivery of cancer drugs.Annual Review of Medicine, 63, 185-198. 13. Cridge, B.J., Larsen, L., Rosengren, R.J., 2013. Curcumin and its derivatives in breast cancer: Current developments and potential for the treatment of drug-resistant cancers. Oncology Discovery, 2052, 1-6.14. Carey, L., Winer, E., Viale, G., Cameron, D., Gianni, L., 2010. Triple-negative breast cancer: disease entity or title of convenience?. Nature Reviews Clinical Oncology, 7(12), 683-692.15. Yallapu, M.M., Othman, S.F., Curtis, E.T., Bauer, N.A., Chauhan, N., Kumar, D., Jaggi, M., Chauhan, S.C., 2012. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. International Journal of Nanomedicine, 7, 1761-1779.16. Lin, W., Cooper, C., Camarillo, I., 2014 June 17-19. The effectiveness of electroporation-based nanocurcumin and curcumin treatments on human breast cancer cells. In: Proceedings of ESA annual meeting on electrostatics, University of Notre Dame, Notre Dame, Indiana., USA, Electrostatics Society of America, 1-7. 17. Ganta, S., Amiji, M., 2009. Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Molecular Pharmaceutics, 6(3), 928-939.18. Bisht, S., Mizuma, M., Feldmann, G., Ottenhof, N., Hong, S.M., Pramanik, D., Chenna, V., Karikari, C., Sharma, R., Goggins, M.G., Rudek, M.A., Ravi, R., Maitra, A., Maitra, A., 2010. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Molecular Cancer Therapeutics, 9(8), 2255-2264. 19. Yallapu, M.M., Ebeling, M.C., Khan, S., Sundram, V., Chauhan, N., Gupta, B.K., Puumala, S.E., Jaggi, M., Chauhan, S.C., 2013. Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. Molecular Cancer Therapy, 12(8), 1471-1480. 20. Ruddon, R.W., 2007. Cancer biology, 4th ed. Oxford University Press, Oxford, 223. 21. Yallapu, M.M., Khan, S., Maher, D.M., Ebeling, M.C., Sundram, V., Chauhan. N., Ganju, A., Balakrishna, S., Gupta, B.K., Zafar, N., Jaggi, M., Chauhan, S.C., 2014. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials, 35(30), 8635-8648. 22. Gopal, J., Muthu, M., Chun, S., 2016. Bactericidal Property of Macro-, Micro- and Nanocurcumin: An Assessment. Arabian Journal Science and Engineering, 41(6),2087–2093.23. Bhawana., Basniwal, R.K., Buttar, H.S., et al. 2011. Curcumin nanoparticles: preparation, characterization, and antimicrobial study. Journal of Agriculture and Food Chemistry, 259(5), 2056–2061.24. Vimala, K., Mohan, Y.M., Varaprasad, K., et al. 2011. Fabrication of Curcumin Encapsulated Chitosan-PVA Silver Nanocomposite Films for Improved Antimicrobial Activity. Journal of Biomaterials and Nanobiotechnology, 2(1), 55–64.25. Gandapu, U., Chaitanya, R.K., Kishore, G., Reddy, R.C., Kondapi, A. K., 2011. Curcumin-Loaded Apotransferrin Nanoparticles Provide Efficient Cellular Uptake and Effectively Inhibit HIV-1 Replication In-Vitro. PLoS One, 6(8), e23388. 26. Akhtar, F., Rizvi, M.M., Kar, S.K., 2012. Biotechnological Advances, 30(1), 310-320. 27. Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., & Diederich, M., 2005. Chemopreventive and therapeutic effects of curcumin. Cancer letters, 223(2), 181-190.28. Luthra, P. M., Singh, R., Chandra, R., 2001. Therapeutic uses of Curcuma longa (turmeric). Indian Journal of Clinical Biochemistry, 16(2), 153-160.29. Singh, A.K., Vinayak, M., 2015. Curcumin attenuates CFA induced thermal hyperalgesia by modulation of antioxidant enzymes and down regulation of TNF-α, IL-1β and IL-6. Neurochemical Research, 40, 463-72.30. Rocha, B.A., Gonçalves, O.H., Leimann, F.V., Rebecca, E.S.W., Silva-Buzanello, R.A., Filho, L.C., Araújo, P.H.H., Cuman, R.K.N., Bersani-Amado, C., A., 2014. Curcumin encapsulated in poly-L-lactic acid improves its anti-inflammatory efficacy in vivo. Advancement in Medicinal Plant Research, 2(4), 62-73.31. Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., Zhang, H.G., 2010. A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes, The American Society of Gene & Cell Therapy, Molecular Therapy, 18(9), 1606-1614.32. Cheng, K.K., Yeung, C.F., Ho, S.W., Chow, S.F., Chow, A.H., Baum, L., 2013. Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood-Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice, American Association of Pharmaceutical Scientists Journal, 15(2), 324-336. 33. Mathew, A., Fukuda, T., Nagaoka, Y., Hasumura, T., Morimoto, H., Yoshida, Y., Maekawa, T., Venugopal, K., Kumar, D.S., 2012. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease., PLoS One, 7(3), e32616.

Details

Primary Language English
Journal Section Review article
Authors

Aminul ISLAM> (Primary Author)
Bio Tex Life Solutions Pvt Ltd
0000-0003-2977-2234
India


Leroy REBELLO This is me
Biotex Life Solutions Private Limited, Hyderabad, India
0000-0002-1570-3417
India


Sreesudha CHEPYALA This is me
Biotex Life Solutions Private Limited, Hyderabad, India,
0000-0002-6317-7600
India

Publication Date June 1, 2019
Submission Date February 19, 2019
Acceptance Date March 16, 2019
Published in Issue Year 2019, Volume 3, Issue 1

Cite

APA Islam, A. , Rebello, L. & Chepyala, S. (2019). Review on Nanoformulations of Curcumin (Curcuma longa Linn.): Special Emphasis on Nanocurcumin® . International Journal of Nature and Life Sciences , 3 (1) , 1-12 . Retrieved from https://dergipark.org.tr/en/pub/ijnls/issue/43966/528804