Investigation the Biological Activities of Chenopdium foliosum Methanol Extract

Yıl 2024, Cilt: 10 Sayı: 2, 579 - 589, 31.12.2024

Özge Vazgeçen , Irmak Icen Taskın , Meryem Rüveyda Sever , Pelin Yılmaz Sancar

https://doi.org/10.29132/ijpas.1433939

Öz

Chenopodium cinsi Türkiye dahil hemen hemen dünyanın her yerinde yayılış göstermektedir. Bu cinse ait türler farklı ülkelerin geleneksel tıbbında çeşitli hastalıkların tedavisinde kullanılmaktadır. Chenopodium cinsinin farklı türleri anti-kanser, anti-mantar ve anti-bakteriyel etkiler göstermektedir. Chenopo-dium foliosum (C. folisoum) ile ilgili literatürde büyük bir boşluk bulunmak-tadır. Bu çalışmada C. folisoum bitkisinin metanol ekstraktının biyolojik ak-tiviteleri araştırıldı. Anti-kanser aktivitesi, HCT-116 ve A549 hücre hatlarında 3-(4,5-Dimetiltiazol-2-il)-2,5-difeniltetrazolyum bromür (MTT) analizi kullanılarak değerlendirildi. Anti-bakteriyel ve ati-fungal aktivitesi minimum inhibisyon konsantrasyonu (MIC) tahlili ile incelenmiştir. C. folisoum'un metanol ekstraktı, HCT116 ve A549 hücre hatlarının hücre canlılığını sırasıyla %73,4 ± %15,3 ve %78,7 ± %2,3'e düşürdüğü saptanmıştır. C. folisoum ayrıca candida albicans'ın (C. albicans) hücre canlılığını %91,2'ye düşürdüğü saptanmıştır. Elde edilen bulgular C. folisoum metanol ekstraktının HCT116, A549 ve C. albicans'a karşı hem antikanser hem de antifungal etkiye sahip olduğunu göstermektedir.

Anahtar Kelimeler

Chenopodium, anti-cancer, anti-bacterial, anti-fungal

Etik Beyan

The authors declare that this study complies with research and publication ethics.

Destekleyen Kurum

TUBİTAK

Proje Numarası

1919B012217219

Kaynakça

• Gennari, C., Castoldi, D., and Sharon, O. (2007). Natural products with taxol-like anti-tumor activity: Synthetic approaches to eleutherobin and dictyostatin. Pure and Applied Chemistry, 79(2), 173–180.
• Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., and Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249.
• Jermini, M., Dubois, J., Rodondi, P. Y., Zaman, K., Buclin, T., Csajka, C., Orcurto, A., and Rothuizen, L. E. (2019). Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic centre. Scientific Reports, 9(1), 5078.
• Agarwal, G., Carcache, P. J. B., Addo, E. M., and Kinghorn, A. D. (2020). Current status and contemporary approaches to the discovery of antitumor agents from higher plants. Biotech-nology Advances, 38, 107337.
• Gonzalez, C., and Schaeffer, A. J. (1999). Treatment of urinary tract infection: what’s old, what’s new, and what works. World Journal of Urology, 17(6), 372–382.
• Santoro, F. R., Nascimento, A. L. B., Soldati, G. T., Ferreira Júnior, W. S., and Albuquerque, U. P. (2018). Evolutionary ethnobiology and cultural evolution: opportunities for research and dialog. Journal of Ethnobiology and Ethnomedicine, 14(1), 1–14.
• Rababah, T. M., Hettiarachchy, N. S., and Horax, R. (2004). Total Phenolics and Antioxidant Activities of Fenugreek, Green Tea, Black Tea, Grape Seed, Ginger, Rosemary, Gotu Kola, and Ginkgo Extracts, Vitamin E, andtert-Butylhydroquinone. Journal of Agricultural and Food Chemistry, 52(16), 5183–5186.
• Sahreen, S., Khan, M. R., and Khan, R. A. (2014). Effects of Carissa opaca fruits extracts on oxidative pulmonary damages and fibrosis in rats. BMC Complementary and Alternative Med-icine, 14, 1–9.
• Russo, T. A., and Johnson, J. R. (2003). Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem. Microbes and Infection, 5(5), 449–456.
• Furtardo, G. H. C., d’Azevedo, P. A., Santos, A. F., Gales, A. C., Pignatari, A. C. C., and Medeiros, E. A. (2007). Intravenous polymyxin B for the treatment of nosocomial pneumonia caused by multidrug-resistant Pseudomonas aeruginosa. International Journal of Antimicrobial Agents, 30(4), 315–319.
• Shigemura, K., Arakawa, S., Sakai, Y., Kinoshita, S., Tanaka, K., and Fujisawa, M. (2006). Complicated urinary tract infection caused by Pseudomonas aeruginosa in a single institution (1999–2003). International Journal of Urology, 13(5), 538–542.
• Kim, M., Christley, S., Khodarev, N. N., Fleming, I., Huang, Y., Chang, E. B., Zaborina, O., and Alverdy, J. C. (2015). Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact. Journal of Trauma and Acute Care Sur-gery, 78(4), 823–829.
• Shi, Q., Huang, C., Xiao, T., Wu, Z., and Xiao, Y. (2019). A retrospective analysis of Pseudomonas aeruginosa bloodstream infections: prevalence, risk factors, and outcome in carbapenem-susceptible and -non-susceptible infections. Antimicrobial Resistance and Infection Control, 8(1), 1–9.
• Cheung, G. Y. C., Bae, J. S., and Otto, M. (2021). Pathogenicity and virulence of Staphy-lococcus aureus. Virulence, 12(1), 547–569.
• Guo, Y., Song, G., Sun, M., Wang, J., and Wang, Y. (2020). Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus. Frontiers in Cellular and Infection Microbi-ology, 10, 107.
• Guinea, J. (2014). Global trends in the distribution of Candida species causing candidemia. Clinical Microbiology and Infection, 20, 5–10.
• Colombo, A. L., de Almeida Junior, J. N., and Guinea, J. (2017). Emerging multi-drug-resistant Candida species. Current Opinion in Infectious Diseases, 30(6), 528–538.
• Yadav, N., Vasudeva, N., Singh, S., and Sharma, S. K. (2007). Medicinal properties of genus Chenopodium Linn. Natural Product Radiance, 6(2), 131–134.
• Bano, A., Ahmad, M., Zafar, M., Sultana, S., Rashid, S., and Khan, M. A. (2014). Ethno-medicinal knowledge of the most commonly used plants from Deosai Plateau, Western Hima-layas, Gilgit Baltistan, Pakistan. Journal of Ethnopharmacology, 155(2), 1046–1052.
• Kokanova-Nedialkova, Z., Bücherl, D., Nikolov, S., Heilmann, J., and Nedialkov, P. T. (2011). Flavonol glycosides from Chenopodium foliosum Asch. Phytochemistry Letters, 4(3), 367–371.
• Özgen, U., Kaya, Y., and Houghton, P. (2012). Folk medicines in the villages of Ilıca District (Erzurum, Turkey). Turkish Journal of Biology, 36(1), 93–106.
• Udegbunam, S. O., Udegbunam, R. I., Muogbo, C. C., Anyanwu, M. U., & Nwaehujor, C. O. (2014). Wound healing and antibacterial properties of methanolic extract of Pupalia lappacea Juss in rats. BMC Complementary and Alternative Medicine, 14(1).
• Sharma, N., Arya, G., Kumari, R., Gupta, N., & Nimesh, S. (2019). Evaluation of Anticancer activity of Silver Nanoparticles on the A549 Human Lung Carcinoma Cell Lines through Alamar Blue Assay. Bio-Protocol, 9(1).
• Rodriguez-Tudela, J. L., Arendrup, M. C., Barchiesi, F., Bille, J., Chryssanthou, E., Cuen-ca-Estrella, M., Dannaoui, E., Denning, D. W., Donnelly, J. P., Dromer, F., Fegeler, W., Lass-Flörl, C., Moore, C., Richardson, M., Sandven, P., Velegraki, A., & Verweij, P. (2008). EUCAST Definitive Document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clinical Microbiology and Infection, 14(4), 398–405.
• CLSI, C. (2018). Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. CLSI standard M07.
• Acıbuca, V., and Budak, D. B. (2018). Dünya’da ve Türkiye’de Tıbbi ve Aromatik Bitkilerin Yeri ve Önemi. Çukurova Tarım ve Gıda Bilimleri Dergisi, 33(1), 37–44.
• Bhargava, A., Shukla, S., Kumar, R., and Ohri, D. (2009). Metroglyph Analysis of Mor-phological Variation in Chenopodium spp. World Journal of Agricultural Sciences, 5(1), 117–120.
• Khoobchandani, M., Ojeswi, B. K., Sharma, B., and Srivastava, M. M. (2009). Chenopodium Album Prevents Progression of Cell Growth and Enhances Cell Toxicity in Human Breast Cancer Cell Lines. Oxidative Medicine and Cellular Longevity, 2(3), 160–165.
• Baldi, A., and Choudhary, N. K. (2013). In vitro antioxidant and hepatoprotective potential of chenopodium album extract. International Journal of Green Pharmacy, 7(1).
• Gawlik‐Dziki, U., Świeca, M., Maciej Sułkowski, M., Dziki, D., Baraniak, B., and Czyż, J. (2013). Antioxidant and anticancer activities of Chenopodium quinoa leaves extracts – In vitro study. Food and Chemical Toxicology, 57, 154–160.
• Miranda, M., Delatorre-Herrera, J., Vega‐Gálvez, A., Jorquera, E., Quispe‐Fuentes, I., and Martínez, E. A. (2014). Antimicrobial Potential and Phytochemical Content of Six Diverse Sources of Quinoa Seeds (Chenopodium quinoa Willd.). Agricultural Sciences, 05(11), 1015–1024.
• Kokanova-Nedialkova, Z., Nedialkov, P. T., and Nikolov, S. D. (2014). Pharmacognostic investigations of the aerial parts of Chenopodium foliosum Asch. and radical-scavenging ac-tivities of five flavonoids isolated from methanol extract of the plant. Pharmacognosy Journal, 6(4), 43–48.
• Kaur, R., Kapoor, K., and Kaur, H. (2011). Plants as a source of anticancer agents. Journal of Natural Product and Plant Resources, 1(1), 119–124.
• Sala, A., Recio, M. C., Giner, R. M., Máñez, S., Tournier, H., Schinella, G., and Rı́osJ. L. (2002). Anti-inflammatory and antioxidant properties of Helichrysum italicum. Journal of Pharmacy and Pharmacology, 54(3), 365–371.
• Harun-ur-Rashid, Md., Gafur, M. A., Sadik, Md. G., and Rahman, Md. A. A. (2002). Bio-logical Activities of a New Acrylamide Derivative from Ipomoea turpethum. Pakistan Journal of Biological Sciences, 5(9), 968–969.
• Kokanova-Nedialkova, Z., Nedialkov, P., and Momekov, G. (2018). Saponins from the roots of Chenopodium bonus-henricus L. Natural Product Research, 33(14), 2024–2031.
• Nascimento, F. R. F., Cruz, G. V. B., Pereira, P. V. S., Maciel, M. C. G., Silva, L. A., Azevedo, A. C., Barroqueiro, E. S. B., and Guerra, R. N. M. (2006). Ascitic and solid Ehrlich tumor inhibition by Chenopodium ambrosioides L. treatment. Life Sciences, 78(22), 2650–2653.
• Potawale, S. E., Luniya, K. P., Mantri, R. A., Mehta, U. K., Waseem, Md., Sadiq, Md., Vetal, Y. D., and Deshmukh, R. S. (2008). Chenopodium ambrosioides: An ethnopharmacological review. Pharmacologyonline, 2, 272–286.
• Dembitsky, V., Shkrob, I., and Hanus, L. O. (2008). Ascaridole and related peroxides from the genus Chenopodium. Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic, 152(2), 209–215.
• Efferth, T., Olbrich, A., Sauerbrey, A., Ross, D. D., Gebhart, E., and Neugebauer, M. (2022). Activity of ascaridol from the anthelmintic herb Chenopodium anthelminticum L. against sen-sitive and multidrug-resistant tumor cells. Anticancer Research, 22(6C), 4221–4224. https://pubmed.ncbi.nlm.nih.gov/12553060/
• Nedialkov , P. T., Kokanova-Nedialkova, Z., Bücherl, D., Momekov, G., Heilmann, J., & Nikolov, S. (2012). 30-normedicagenic acid glycosides from Chenopodium foliosum. Natural Product Communications, 7(11). https://pubmed.ncbi.nlm.nih.gov/23285798/
• Nejad, B. S., and Deokule, S. S. (2009). Anti-dermatophytic activity of Drynaria quercifolia (L.) J. Smith. Jundishapur Journal of Microbiology, 2(1), 25–30.
• Khan, S. U., Ullah, F., Mehmood, S., Fahad, S., Ahmad Rahi, A., Althobaiti, F., Dessoky, E. S., Saud, S., Danish, S., and Datta, R. (2021). Antimicrobial, antioxidant and cytotoxic properties of Chenopodium glaucum L. PLOS ONE, 16(10).
• Kaur, N., and Kaur, G. (2018). Effect of processing on nutritional and antinutritional composition of bathua (Chenopodium album) leaves. Journal of Applied and Natural Science, 10(4), 1149–1155.
• Ajaib, M., Hussain, T., Farooq, S., and Ashiq, M. (2016). Analysis of Antimicrobial and Antioxidant Activities of Chenopodium ambrosioides An Ethnomedicinal Plant. Journal of Chemistry, 1–11.
• Jardim, C. M., Jham, G. N., Dhingra, O. D., and Freire, M. M. (2010). Chemical composition and antifungal activity of the hexane extract of the Brazilian Chenopodium ambrosioides L. Journal of the Brazilian Chemical Society, 21(10), 1814–1818.