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Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants

Year 2021, Volume 1, Issue 1, 42 - 47, 15.12.2021

Abstract

Since hospital-acquired microorganisms are developing more and more resistance to antibiotics used today, researchers are turning to new searches in the treatment of infectious diseases. Unfortunately, unconscious use of antibiotics is another important reason why microorganisms develop resistance to infectious diseases. The aim of this study was to test the antimicrobial activity of some hydroxybenzoic and hydroxycinnamic acids on various gram-positive and gram-negative bacteria and a yeast strain (C. albicans). Agar well diffusion and minimum inhibitory concentration (MIC) tests were applied to determine the antimicrobial activities of phenolic acids. Considering the activity findings of phytochemicals on all test microorganisms, they were ranked in terms of their activities with a statistical method called the relative inhibitory capacity index (RICI) (a method that was first introduced in the literature by the current study). RICI analysis showed that the most effective phenolic acids for all test microorganisms were sinapic acid and 4-hydroxybenzoic acid. The RICI coefficients of these compounds were 1.02 and 0.99, respectively. Sinapic acid exhibited a zone of inhibition of 9.00-27.00 mm and an MIC of 18.00-72.00 mg/ml on microorganisms. Inhibition zone and MIC value ranges of 4-hydroxybenzoic acid were determined as 9.00-16.00 mm and 36.00-72.00 mg/ml, respectively. RICI analyzes confirmed that 2-phenylbutyric acid and phloroglucinol carboxylic acid did not show any antimicrobial activity. It is thought that sinapic acid and 4-hydroxybenzoic acid can be used as alternative antimicrobial agents against multi drug resistant microorganisms.

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Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Research Articles
Authors

Aslihan GURBUZER This is me
SIVAS CUMHURIYET UNIVERSITY
0000-0002-6753-2808
Türkiye

Supporting Institution Research Council of Sivas Cumhuriyet University
Project Number F-354
Thanks The author thanks to the Research Council of Sivas Cumhuriyet University for the financial support (Project no: F-354) and to Prof. Dr. Cengiz SARIKURKCU for his contribution to the ANOVA and RICI analysis. The data presented in this article are derived from Aslihan GURBUZER's master's thesis.
Publication Date December 15, 2021
Application Date June 20, 2021
Acceptance Date June 30, 2021
Published in Issue Year 2021, Volume 1, Issue 1

Cite

Bibtex @research article { ijpbp975576, journal = {International Journal of Plant Based Pharmaceuticals}, issn = {}, eissn = {2791-7509}, address = {Kilis 7 Aralık Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü, 79000, Merkez-KİLİS}, publisher = {Kilis 7 Aralik University}, year = {2021}, volume = {1}, pages = {42 - 47}, doi = {}, title = {Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants}, key = {cite}, author = {Gurbuzer, Aslihan} }
APA Gurbuzer, A. (2021). Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants . International Journal of Plant Based Pharmaceuticals , 1 (1) , 42-47 . Retrieved from https://dergipark.org.tr/en/pub/ijpbp/issue/64282/975576
MLA Gurbuzer, A. "Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants" . International Journal of Plant Based Pharmaceuticals 1 (2021 ): 42-47 <https://dergipark.org.tr/en/pub/ijpbp/issue/64282/975576>
Chicago Gurbuzer, A. "Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants". International Journal of Plant Based Pharmaceuticals 1 (2021 ): 42-47
RIS TY - JOUR T1 - Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants AU - Aslihan Gurbuzer Y1 - 2021 PY - 2021 N1 - DO - T2 - International Journal of Plant Based Pharmaceuticals JF - Journal JO - JOR SP - 42 EP - 47 VL - 1 IS - 1 SN - -2791-7509 M3 - UR - Y2 - 2021 ER -
EndNote %0 International Journal of Plant Based Pharmaceuticals Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants %A Aslihan Gurbuzer %T Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants %D 2021 %J International Journal of Plant Based Pharmaceuticals %P -2791-7509 %V 1 %N 1 %R %U
ISNAD Gurbuzer, Aslihan . "Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants". International Journal of Plant Based Pharmaceuticals 1 / 1 (December 2021): 42-47 .
AMA Gurbuzer A. Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants. Int. J. Plant Bas. Pharm.. 2021; 1(1): 42-47.
Vancouver Gurbuzer A. Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants. International Journal of Plant Based Pharmaceuticals. 2021; 1(1): 42-47.
IEEE A. Gurbuzer , "Investigation of in vitro antimicrobial activities of some hydroxybenzoic and hydroxycinnamic acids commonly found in medicinal and aromatic plants", International Journal of Plant Based Pharmaceuticals, vol. 1, no. 1, pp. 42-47, Dec. 2021

Open Access Policy: This journal (IJPBP) adopted Budapest Open Access Initiative definition. The journal follows Committee on Publication Ethics (COPE) guidelines on the Code of Conduct and supports open access.

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