Türkiye'deki Yetişkinlerde BioNTech mRNA ve Sinovac Aşılarının Olumsuz Etkilerinin Karşılaştırılması

Abstract

Amaç: Bu çalışmanın amacı, Türkiye'deki yetişkinlerde uygulanan Pfizer-BioNTech mRNA and Sinovac-CoronaVac -CoronaVac aşılarının yan etkilerini karşılaştırmaktır. Gereç ve Yöntem: Bu araştırma kesitsel bir çalışmadır. Araştırmanın örneklemini Pfizer- BioNTech grubunda 95, Sinovac-CoronaVac grubunda 92 olmak üzere aşı için gelen 187 yetişkin oluşturdu. Bir hastanede aşılanan bireylere Görsel Analog Skala (VAS) ve kişisel bilgi anketi uygulandı. Aşıdan 6,12 ve 24 saat sonra herhangi bir yan etki olup olmadığı soruldu. Bulgular: En yaygın lokal yan etki enjeksiyon bölgesinde ağrıydı, ancak en sık sistemik yan etkiler her iki grupta da halsizlik ve baş ağrısıydı. Pfizer-BioNTech aşısı ile aşılanan katılımcılarımızın çoğu (%87,4) ve Sinovac-CoronaVac alanların yaklaşık yarısı (%48,9) yan etki bildirdi. Enjeksiyon bölgesinde hissedilen ağrı Pfizer-BioNTech grubunda %86,3, Sinovac-CoronaVac grubunda %44,6’dır. Hem Pfizer-BioNTech hem de Sinovac- CoronaVac aşıları ile aşılanan katılımcılarda en az ağrı şiddeti 24. saat içinde görüldü. Sonuç: Enjeksiyon bölgesindeki ağrı düzeyi Pfizer-BioNTech aşısında Sinovac- CoronaVac aşısına göre daha yüksektir. Çalışmamızda her iki aşıda da en fazla sistemik yan etki halsizlik ve baş ağrısı olmuştur.

Keywords

• Hemşire
• yan etki
• Pfizer-BioNTech
• Sinovac-CoronaVac
• aşı
• ağrı

Comparison of Adverse Effects of BioNTech mRNA and Sinovac Vaccines in Adults in Turkey

Abstract

Objective: The aim of this study is to compare the side effects of Pfizer-BioNTech mRNA and Sinovac-CoronaVac vaccines administered in adults in Turkey. Material and Method: This is a cross-sectional study. The study sample consisted of 187 adults, 95 in the Pfizer-BioNTech group and 92 in the Sinovac-CoronaVac group, who came for vaccination. A Visual Analogue Scale (VAS) and a questionnaire were applied to vaccinated individuals in a hospital. They were asked about any adverse effects at 6, 12 and 24 hours post-vaccination. Results: The most common local adverse effect was pain at the injection site, but the most frequent systemic adverse effects were weakness and headache in both groups. Most (87.4%) of our participants who were vaccinated with the Pfizer-BioNTech vaccine and nearly half (48.9%) of those who received Sinovac-CoronaVac reported adverse effects. Pain felt at the injection site was 86.3% in the Pfizer-BioNTech group and 44.6% in the Sinovac-CoronaVac group. The least pain intensity in participants who were vaccinated with both Pfizer-BioNTech and Sinovac-CoronaVac vaccines was seen in the 24 hours. Conclusion: The pain level at the injection site after Pfizer-BioNTech was higher than the Sinovac-CoronaVac vaccine. In our study the most systemic adverse effects with both vaccines were weakness and headache.

Keywords

• Nursing
• adverse effects
• Pfizer-BioNTech
• Sinovac-CoronaVac
• vaccines
• pain

References

1. Yavuz E. COVID-19 Vaccines. Turkish J Fam Pract. 2020;24(4):227–34.
2. Hernández AF, Calina D, Poulas K, Docea AO, Tsatsakis AM. Safety of COVID-19 vaccines administered in the EU: Should we be concerned? Toxicol Reports. 2021;8:871–9.
3. Mullard A. Flooded by the torrent: the COVID-19 drug pipeline. Lancet. 2020;395(10232):1245–6.
4. Zhu N, Dingyu Z, Wenling W, Li X, Yang B, Ma X, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–33.
5. Rabi R, Maraqa B, Nazzal Z, Zink T. Factors affecting nurses’ intention to accept the COVID-19 vaccine: A cross-sectional study. Public Health Nurs. 2021;38(5):781–8.
6. Roberts K, Sidhu N, Russel M, Abbas MJ. Psychiatric pathology potentially induced by COVID-19 vaccine. Prog Neurol Psychiatry. 2021;25(4):8–10.
7. Ming S, Mph L, Ching H, Mph C, Mbbs AS, Quek SC, et al. Safety and side effect profile of Pfizer-Pfizer-BioNTech COVID-19 vaccination among healthcare workers : A tertiary hospital experience in Singapore. Ann Acad Med Singap. 2021;50(9):703–11.
8. Fix OK, Blumberg EA, Chang KM, Chu J, Chung RT, Goacher EK, et al. American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease. Hepatology. 2021;74(2):1049–64.

9. Kadali RAK, Janagama R, Peruru S, Malayala S V. Side effects of BNT162b2 mRNA COVID-19 vaccine: A randomized, cross-sectional study with detailed self-reported symptoms from healthcare workers. Int J Infect Dis. 2021;106:376–81.
10. Dayan S. COVID - 19 ve Aşı. Dicle Med J. 2021;48:98–113.
11. Al Khames Aga QA, Alkhaffaf WH, Hatem TH, Nassir KF, Batineh Y, Dahham AT, et al. Safety of COVID-19 vaccines. J Med Virol. 2021;93(12):6588–94.
12. Jęśkowiak I, Wiatrak B, Grosman-Dziewiszek P, Szeląg A. The incidence and severity of post-vaccination reactions after vaccination against covid-19. Vaccines. 2021;9(5).
13. Yoo JH. What We Do Know and Do Not Yet Know about COVID-19 Vaccines as of the Beginning of the Year 2021. J Korean Med Sci. 2021;36(6):1–17.
14. Abu-Hammad O, Alduraidi H, Abu-Hammad S, Alnazzawi A, Babkair H, Abu-Hammad A, et al. Side effects reported by jordanian healthcare workers who received covid-19 vaccines. Vaccines. 2021;9(6):1–10.
15. Dziedzic A, Riad A, Attia S, Klugar M, Tanasiewicz M. Self-reported adverse events of COVID-19 vaccines in polish healthcare workers and medical students. Cross-sectional study and pooled analysis of CoVaST project results in central europe. J Clin Med. 2021;10(22).
16. Riad A, Sagıroglu D, Batuhan Ü, Sameh A, Miloslav K, Andrea P, et al. Prevalence and Risk Factors of CoronaVac Side Effects : An Independent Cross-Sectional Study among Healthcare Workers in Turkey. J Clin Med Artic. 2021;10(2629):1–13.
17. Mohammed RA, Garout RM, Wahid S, Ayub F, Zinalddin LMF. A Survey on the Side Effects of Pfizer / Pfizer-BioNTech COVID-19 Vaccine Among Vaccinated Adults in Saudi Arabia. Cureus. 2021;13(11).
18. Klugar M, Riad A, Mekhemar M, Conrad J, Buchbender M, Howaldt HP, et al. Side effects of mrna-based and viral vector-based covid-19 vaccines among german healthcare workers. Biology (Basel). 2021;10(8):1–21.
19. Alhazmi A, Alamer E, Daws D, Hakami M, Darraj M, Abdelwahab S, et al. Evaluation of Side Effects Associated with COVID-19 Vaccines in Saudi Arabia. Vaccines. 2021;9(674):1–8.
20. Takeyama R, Fukuda K, Kouzaki Y, Koga T, Hayashi S, Ohtani H, et al. Intracerebral hemorrhage due to vasculitis following COVID-19 vaccination: a case report. Acta Neurochir (Wien). 2022;164(2):543–7.
21. Zhang MX, Zhang TT, Shi GF, Cheng FM, Zheng YM, Tung TH, et al. Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China. Expert Rev Vaccines. 2021;20(7):891–8.
22. Yigit M, Ozkaya-Parlakay A, Senel E. Evaluation of COVID-19 Vaccine Refusal in Parents. Pediatr Infect Dis J. 2021;40(4):E134–6.
23. Castells MC, Phillips EJ. Maintaining Safety with SARS-CoV-2 Vaccines. N Engl J Med. 2021;384(7):643–9.
24. Bhopal SS, Olabi B, Bhopal R. Vaccines for COVID-19: learning from ten phase II trials to inform clinical and public health vaccination programmes. Public Health. 2021;193:57–60.
25. Batı S, Burucu R, Cantekin I, Dönmez H. Determining The Side Effects Of Covid-19 (Sinovac-CoronaVac ) Vaccination On Nurses; An Independent Descriptive Study. Konuralp Tıp Derg. 2021;19:479–87.
26. Abu-halaweh S, Alqassieh R, Suleiman A, Al-sabbagh MQ. Qualitative Assessment of Early Adverse Effects of Pfizer – Pfizer-BioNTech and Sinopharm COVID-19 Vaccines by Telephone Interviews. Vaccines. 2021;9(950):2–10.
27. Seidl H, Hunger M, Meisinger C, Kirchberger I, Kuch B, Leidl R, et al. The 3-Year Cost-Effectiveness of a Nurse-Based Case Management versus Usual Care for Elderly Patients with Myocardial Infarction: Results from the KORINNA Follow-Up Study. Value Heal. 2017;20(3):441–50.
28. Elgendy MO, El-Gendy AO, Mahmoud S, Mohammed TY, Abdelrahim MEA, Sayed AM. Side Effects and Efficacy of COVID-19 Vaccines among the Egyptian Population. Vaccines. 2022;10(1):7–9.
29. El-Shitany A N, Harakeh S, Badr-Eldin SM, Bagher AM, Eid B, Badrah HA, et al. Minor to Moderate Side Effects of Pfizer-Pfizer-BioNTech COVID-19 Vaccine Among Saudi Residents : A Retrospective Cross- Sectional Study. Int J Gen Med. 2021;14:1389–401.
30. Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P, et al. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis. 2021;21(7):939–49.
31. Goss AL, Samudralwar RD, Das RR, Nath A. ANA Investigates: Neurological Complications of COVID-19 Vaccines. Ann Neurol. 2021;89(5):856–7.