Akromegali ve Gebelik

Mehmet Kulhan; Nur Gözde Kulhan; Ümit Naykı; Cenk Naykı; Paşa Uluğ

Akromegali ve Gebelik

Abstract

Akromegali ve Gebelik

Özet (≤250 KELİME)

Akromegali, büyüme hormonunu aşırı sekresyonunun oluşturduğu metabolik etkiler ve hipofiz adenomunun oluşturduğu direkt kitle etkisi ile morbidite ve mortalitede artış ile seyreder. Gonadotropik aks genelde bozuktur ve tedavi edilmeyen kadınlarda gebelik elde etmek zordur. Bu nedenle gebelik ve akromegali nadir bir birlikteliktir ve literatürde oldukça az olgu bildirilmiştir. Dahası, akromegalisi olan gebe kadınlar diabetes mellitus ve kalp damar hastalık prevalansının yüksek olması nedeni ile yüksek riskli gebeliklerdir. Aşağıda transsfenoidal cerrahi ve takiben medikal tedavi sonrası spontan gebelik oluşan bir akromegali olgusu sunulmuştur.

Anahtar Kelimeler: (3-5 Kelime): Akromegali, Büyüme Hormonu, Gebelik

Acromegaly and Pregnancy

Abstract (≤250 WORDS)

In acromegaly, the metabolic effects caused by oversecretion of growth hormone and direct mass effect caused by adenoma of the hypophysis lead to increase in morbidity and mortality. Gonotrophic axis is usually defective and pregnancy hardly occurs in nontreated acromegalic women. Thus, pregnancy with acromegaly is uncommon and there are limited reports in literature. Moreover, pregnant women with acromegaly are accepted as high risk pregnancies because of the increased prevelance of diabetes mellitus and cardiovascular diseases. We present a case of acromegalic patient who had spontaneous pregnancy after transsphenoidal surgery followed by medical treatment.

Keywords: (3-5 Words): Acromegaly, Growth Hormone, Pregnancy.

Keywords

Akromegali,Büyüme Hormonu

References

Advis, J.P., White, S.S. & Ojeda, S.R. (1981). Activation of growth hormone short loop negative feedback delays puberty in the female rat. Endocrinology. 108(4),1343-1352.
Beckers, A., Stevenaert, A., Foidart, J.M., Hennen, G. & Frankenne, F. 1990). Placental and pituitary growth hormone secretion during pregnancy in acromegalic women. J Clin Endocrinol Metab. 71,725- 731.
Boulanger, C., Vezzosi, D., Bennet, A., Lorenzini, F., Fauvel, J. & Caron, P. (2004). Normal pregnancy in a woman with nesidioblastosis treated with somatostatin analog octreotide. J Endocrinol Invest. 27(5),465-470.
Bronstein, M.D., Salgado, L.R. & de Castro Musolino, N.R. (2002) Medical management of pituary adenomas: the special case of management of the pregnant woman. Pituitary 5(2),99-107.
Caron, P., Broussaud, S., Bertherat, J., Borson-Chazot, F., Brue, T., CortetRudelli, C. & Chanson, P. (2010). Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 95(10),4680-4687.
Caron, P., Buscail, L., Beckers, A., Esteve, J.P., Igout, A., Hennen, G. & Susini, C. (1997). Expression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy. J Clin Endocrinol Metabol. 82(11), 3771–3776.
Caron, P., Gerbeau, C. & Pradayrol, L. (1995). Maternal–fetal transfer of octreotide. N Eng J Med 333(9),601–602.
Cheng, S., Grasso, L., Martinez-Orozco, J.A., Al-Agha R., Pivonello, R., Colao, A., et al. (2012). Pregnancy in acromegaly: Experience from two referral centers and systematic review of the literature. Clin Endocrinol (Oxf) 76(2),264-271.

Cozzi, R., Attanasio, R. & Barausse, M. (2006). Pregnancy in acromegaly: A one-center experience. Eur J Endocrinol. 155(2),279-284. Davidoff, L.M. & Bull, N.Y. (1940) Hyperpituitarism and hypopituitarism. Acad Med 16(4), 227.
Demura, R., Ono, M., Demura, H., Schizume, D.K. & Oouchi, H. (1982). Prolactin directly inhibits basal as well as gonadotropin-stimulated secretion of progesterone and 17b-estradiol in the human ovary. JnClin Endocrinol Metab. 54(6), 1246 –1250.
Fassnacht, M., Capeller, B., Arlt, W., Steck, T. & Allolio, B. (2001). Octreotide LAR treatment throughout pregnancy in an acromegalic woman. Clin Endocrinol 55(3), 411–415.
Goluboff, L.G. & Enrin, C. (1969). Effect of pregnancy on the somatotroph and the prolactin cell of the human adenohypophysis. J Clin Endocrinol Metab 29(12), 1533-1538.
Herman-Bonert, V., Seliverstov, M. & Melmed, S. (1998). Pregnacy in acromegaly: succesfull therapeutic outcome. J Clin Endocrinol Metab 83(3), 727-731.
Hsu, C.J. & Hammond, J.M. (1987). Concomitant effects of growth hormone on secretion of insulin-like growth factor I and progesterone by cultured porcine gramulosa cells. Endocrinology 121(4), 1343–1348.
Kashyap, R.R., Babu, G.S. & Shetty, S.R. (2011). Dental patient with acromegaly: a case report. J Oral Sci 53(1), 133-36.
Kupersmith, M.J., Rosenberg, C. & Kleinberg, D. (1994). Visual loss in pregnant women with pituitary adenomas. Ann Intern Med 121(7), 473-477.
Leandro, K., Leonardo, V.N., Takiya, C. M. & Mônica, R.G. (2012). Growth of an aggressive tumor during pregnancy in anacromegalic patient. Endocr J 59(4), 313-319.
Lois, K., Bukowczan, J., Perros, P., Jones, S., Gunn, M. & James, R.A. (2014) The role of colonoscopic screening in acromegaly revisited: review of current literature and practice guidelines. Pituitary. Jul 23[ Epub ahead of print].
Lombardi, G., Di Somma, C., Grasso, L.F., Savanelli, M.C., Colao, A. & Pivonello, R. (2012). The cardiovascular system in growth hormone excess and growth hormone deficiency. J Endocrinol Invest. 35(11), 1021-1029.
Magyar, D.M. & Marshall, J.R. (1978). Pituitary tumors and pregnancy. Am J Obstet Gynecol 132, 739-751.
Molitch, M.E. (1985). Pregnancy and hyperprolactinemic women. N Engl J Med. 312(21), 1364–1370.
Sauder, S.E., Frager, M., Case, G.D., Kelch, R.P. & Marshall, J.C. (1984). Abnormal patterns of pulsalite luteinizing hormone secretion in women with hyperprolactinemia and amenorrhea: responses to bromocriptine. J Clin Endocrinol Metab. 59(5), 941-948.
Schöfl, C., Grussendorf, M., Honegger, J., Tönjes, A., Thyroke-Gronostay, D., Mayr, B.M. & Schopohl, J. (2015) Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. Eur J Endocrinol. 172(4), 351-356.
Thoma, K.H. (1950). Oral pathology: a histo¬logical rontgenological and clinical study of diseases of the teeth, jaws and mouth. 4th ed. St. Louis: Mosby,710-714.
Tonyukuk Gedik, V. (2007). Acromegally: epidemiology, etiology and classification. Turkiye Klinikleri J Int Med Sci. 3(37), 6-8.
Turkalj, I., Braun, P. & Krupp, P. (1982). Surveillance of bromocriptine in pregnancy. JAMA 247(11), 1589–1591.
Viollet, C., Bodenant, C., Prunotto, C., Roosterman, D., Schaefer, J., Meyerhof, W., Epelbaum, J., Vaudry, H. & Leroux, P. (1997). Differential expression of multiple somatostatin receptors in the rat cerebellum during development. J Neurochem. 68(6), 2263-2272.
Winters, J.J. & Troen, P. (1984). Altered pulsatile secretion of lutenizing hormone in hypogonadal men with hyperprolactinemia. Clin Endocrinol (Oxf). 21(3), 257–163.
Yamamoto, M., Fukuoka, H., Iguchi, G., Matsumoto, R., Takahashi, M., Nishizawa, H., Suda, K., Bando, H. & Takahashi, Y. (2014). The prevalence and associated factors of colorectal neoplasms in acromegaly: a single center based study. Pituitary. Jun 20 [ Epub ahead of print]

Details

Primary Language

Turkish

Subjects

-

Journal Section

Case Report

Authors

Mehmet Kulhan ^*

Nur Gözde Kulhan This is me

Ümit Naykı This is me

Cenk Naykı This is me

Paşa Uluğ This is me

Publication Date

January 10, 2017

Submission Date

August 23, 2016

Acceptance Date

-

Published in Issue

Year 2017 Volume: 2 Number: 1

IZ

https://izlik.org/JA69GR63HP

Cite

RIS / Bibtex

APA

Kulhan, M., Kulhan, N. G., Naykı, Ü., Naykı, C., & Uluğ, P. (2017). Akromegali ve Gebelik. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 2(1), 51-53. https://izlik.org/JA69GR63HP

AMA

1.Kulhan M, Kulhan NG, Naykı Ü, Naykı C, Uluğ P. Akromegali ve Gebelik. İKÇÜSBFD. 2017;2(1):51-53. https://izlik.org/JA69GR63HP

Chicago

Kulhan, Mehmet, Nur Gözde Kulhan, Ümit Naykı, Cenk Naykı, and Paşa Uluğ. 2017. “Akromegali Ve Gebelik”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 2 (1): 51-53. https://izlik.org/JA69GR63HP.

EndNote

Kulhan M, Kulhan NG, Naykı Ü, Naykı C, Uluğ P (January 1, 2017) Akromegali ve Gebelik. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 2 1 51–53.

IEEE

[1]M. Kulhan, N. G. Kulhan, Ü. Naykı, C. Naykı, and P. Uluğ, “Akromegali ve Gebelik”, İKÇÜSBFD, vol. 2, no. 1, pp. 51–53, Jan. 2017, [Online]. Available: https://izlik.org/JA69GR63HP

ISNAD

Kulhan, Mehmet - Kulhan, Nur Gözde - Naykı, Ümit - Naykı, Cenk - Uluğ, Paşa. “Akromegali Ve Gebelik”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 2/1 (January 1, 2017): 51-53. https://izlik.org/JA69GR63HP.

JAMA

1.Kulhan M, Kulhan NG, Naykı Ü, Naykı C, Uluğ P. Akromegali ve Gebelik. İKÇÜSBFD. 2017;2:51–53.

MLA

Kulhan, Mehmet, et al. “Akromegali Ve Gebelik”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, vol. 2, no. 1, Jan. 2017, pp. 51-53, https://izlik.org/JA69GR63HP.

Vancouver

1.Mehmet Kulhan, Nur Gözde Kulhan, Ümit Naykı, Cenk Naykı, Paşa Uluğ. Akromegali ve Gebelik. İKÇÜSBFD [Internet]. 2017 Jan. 1;2(1):51-3. Available from: https://izlik.org/JA69GR63HP