Evaluation of Autosomal Dominant Polycystic Kidney Disease with Magnetic Resonance Imaging Findings

Year 2022, , 530 - 538, 20.06.2022

Nurullah Dağ

https://doi.org/10.33715/inonusaglik.1087923

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease, characterized by progressive cystic growth of the kidneys and impaired kidney function. ADPKD is a multisystemic disease and as the disease progresses, its effects are seen in other organs. Radiological imaging is critical for ADPKD diagnosis and the follow-up of treatment efficacy. Our aim in this study is to evaluate renal and extrarenal abdominal findings in ADPKD with magnetic resonance imaging (MRI). In addition, the relationship between MRI findings and clinical and laboratory data has been investigated. In the study, 36 patients over the age of 18 who underwent abdominal MRI between January 2020 and November 2021 have been examined. The mean total kidney volume (TBV) was 113.8±842.2 mL (range, 326.5 - 4498.6 mL). Hemorrhagic cysts were detected in the kidney in 22 patients (61%). There was at least one cyst in the liver of 31 patients (86.1%). Common bile duct dilatation was detected in 11 patients (30.6%). We found a statistically significant correlation between TBV and glomerular filtration rate, creatinine levels, common bile duct dilatation and abdominal/flank pain. In conclusion, MRI provides useful information in the evaluation of renal and extrarenal findings related to ADPKD and can be used effectively.

Keywords

Autosomal dominant polycystic kidney disease, Magnetic resonance imaging, Radiology

OTOZOMAL DOMİNANT POLİKİSTİK BÖBREK HASTALIĞININ MANYETİK REZONANS GÖRÜNTÜLEME BULGULARI EŞLİĞİNDE DEĞERLENDİRİLMESİ

Abstract

Otozomal dominant polikistik böbrek hastalığı (ODPBH) en sık görülen kalıtımsal böbrek hastalığı olup böbreklerde ilerleyici kistik büyüme ve böbrek fonksiyonlarında bozulma ile karakterizedir. ODPBH multisistemik bir hastalıktır ve hastalık ilerledikçe diğer organlarda da etkileri görülmektedir. ODPBH tanısında ve tedavi etkinliğinin takibinde radyolojik görüntüleme kritik önem taşır. Bu çalışmada amacımız ODPBH’nda böbrek ve böbrek dışı abdominal bulguları manyetik rezonans görüntüleme (MRG) ile değerlendirmektir. Ayrıca MRG bulguları ile klinik ve laboratuvar verileri arasındaki ilişki araştırılmıştır. Çalışmada, Ocak 2020 ile Kasım 2021 tarihleri arasında, abdominal MRG incelemesi yapılmış, 18 yaş üzeri, 36 hasta incelenmiştir. Ortalama toplam böbrek volümü (TBV) 1113.8±842.2 mL (aralık, 326.5 – 4498.6 mL)’di. 22 hastada (%61) böbrekte hemorajik kist tespit edildi. 31 hastanın (%86.1) karaciğerinde en az 1 adet kist vardı. 11 hastada (%30.6) koledok dilatasyonu saptandı. TBV ile glomerüler filtrasyon oranı, kreatin düzeyleri, koledok dilatasyonu ve karın/yan ağrısı arasında istatistiksel olarak anlamlı bir korelasyon tespit ettik. Sonuç olarak MRG, ODPBH’na bağlı böbrek ve böbrek dışı bulguların değerlendirilmesinde yararlı bilgiler sağlamaktadır ve etkin bir şekilde kullanılabilir.

Keywords

Manyetik rezonans görüntüleme, Otozomal dominant polikistik böbrek hastalığı, Radyoloji

References

• Bae, K. T. ve Grantham, J. J. (2010). Imaging for the prognosis of autosomal dominant polycystic kidney disease. Nature Reviews Nephrology, 6(2), 96-106.
• Bae, K. T., Zhu, F., Chapman, A. B., Torres, V. E., Grantham, J. J., Guay-Woodford, L. M., ...Kenney, P. J. (2006). Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort. Clinical Journal of the American Society of Nephrology, 1(1), 64-69.
• Bergmann, C., Guay-Woodford, L. M., Harris, P. C., Horie, S., Peters, D. J. ve Torres, V. E. (2018). Polycystic kidney disease. Nature Reviews Disease Primers, 4(1), 1-24.
• Chapman, A. B. ve Wei, W. (2011). Imaging approaches to patients with polycystic kidney disease. Paper Presented at the Seminars in Nephrology. 31(3), 237-244.
• Colbert, G. B., Elrggal, M. E., Gaur, L. ve Lerma, E. V. (2020). Update and review of adult polycystic kidney disease. Disease-a-Month, 66(5), 100887.
• Farooq, Z., Behzadi, A. H., Blumenfeld, J. D., Zhao, Y. ve Prince, M. R. (2017). Complex liver cysts in autosomal dominant polycystic kidney disease. Clinical imaging, 46, 98-101. Gradzik, M., Niemczyk, M., Gołębiowski, M. ve Pączek, L. (2016). Diagnostic imaging of autosomal dominant polycystic kidney disease. Polish journal of radiology, 81, 441.
• Grantham, J. J., Torres, V. E., Chapman, A. B., Guay-Woodford, L. M., Bae, K. T., King Jr, B. F., ...Harris, P. C. (2006). Volume progression in polycystic kidney disease. New England Journal of Medicine, 354(20), 2122-2130.
• Halvorson, C. R., Bremmer, M. S. ve Jacobs, S. C. (2010). Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment. International Journal Of Nephrology and Renovascular Disease, 3, 69.
• Ingelfinger, J. R. (2017). Tolvaptan and autosomal dominant polycystic kidney disease. Mass Medical Soc., 377, 1988-1989.
• Irazabal, M. V., Rangel, L. J., Bergstralh, E. J., Osborn, S. L., Harmon, A. J., Sundsbak, J. L., ...Mrug, M. (2015). Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials. Journal of the American Society of Nephrology, 26(1), 160-172.
• Judge, P. K., Harper, C. H., Storey, B. C., Haynes, R., Wilcock, M. J., Staplin, N., ...Goldacre, M. (2017). Biliary tract and liver complications in polycystic kidney disease. Journal of the American Society of Nephrology, 28(9), 2738-2748.
• Liebau, M. C. ve Serra, A. L. (2013). Looking at the (w) hole: magnet resonance imaging in polycystic kidney disease. Pediatric nephrology, 28(9), 1771-1783.
• Pei, Y. (2006). Diagnostic approach in autosomal dominant polycystic kidney disease. Clinical Journal of the American Society of Nephrology, 1(5), 1108-1114.
• Pei, Y. ve Watnick, T. (2010). Diagnosis and screening of autosomal dominant polycystic kidney disease. Advances in Chronic Kidney Disease, 17(2), 140-152.
• Rahbari-Oskoui, F., Mittal, A., Mittal, P. ve Chapman, A. (2014). Renal relevant radiology: radiologic imaging in autosomal dominant polycystic kidney disease. Clinical Journal of the American Society of Nephrology, 9(2), 406-415.
• van Aerts, R. M., Kievit, W., de Jong, M. E., Ahn, C., Bañales, J. M., Reiterová, J., ...Drenth, J. P. (2019). Severity in polycystic liver disease is associated with aetiology and female gender: results of the International PLD Registry. Liver International, 39(3), 575-582.
• Zhang, W., Blumenfeld, J. D. ve Prince, M. R. (2019). MRI in autosomal dominant polycystic kidney disease. Journal of Magnetic Resonance Imaging, 50(1), 41-51.