Periferik ve Santral Fasiyal Paralizide Yeni Bir İnflamatuar Belirteç Olarak Sistemik İmmün-İnflamasyon İndeksinin Rolü ve Değerlendirilmesi

Year 2023, , 1792 - 1801, 16.10.2023

İsmail Demir , Ahmet Adıgüzel

https://doi.org/10.33715/inonusaglik.1325129

Abstract

Sistemik immün-inflamasyon indeksi (SII) yeni bir inflamatuar belirteç olup, genellikle prognoz ve tedaviye yanıt gibi klinik takiplerde kullanılır. Bu çalışmada santral ve periferik fasiyal paralizilerde inflamatuvar belirteçlerin sonuçları ve korelasyonları değerlendirildi. Çalışma retrospektif ve kesitsel olarak planlandı. Araştırmaya toplam 133 (grup 1; 53, grup 2; 80) hasta dâhil edildi. Nötrofil sayısı 1. ve 2. gruplarda sırasıyla; 4.7 ± 1.6 ve 3.7 ± 1.6 (p=0.001) iken, lenfosit sayıları 2.8 ± 0.8 ve 3.3 ± 1 (p=0.007) tespit edildi. Santral fasiyal paralizisi olanlarda Nötrofil lenfosit oranı (NLR) 1.8 ± 0.9 iken, periferik fasiyal paralizisi olanlarda NLR 1.4 ± 1 (p=0.001) olarak analiz edildi. Sistemik immün-inflamasyon indeksi; birinci grupta 529.5 ± 297.4, ikinci grupta 408.2 ± 228.1 olarak tespit edildi (p=0.029). NLR ile SII arasında pozitif korelasyon (r:0.787, p<0.001) vardı. Periferik fasiyal paralizisi olanlar H-B skalasına göre değerlendirildi [(median:3, min-max:2-6)]. Sonuç olarak, merkezi sinir sistemini etkileyen patolojilerde inflamatuar belirteçlerdeki artış dikkat çekmiştir. NLR ve SII değerleri santral fasiyal paralizide daha yükselmiştir.

Keywords

İnflamasyon, Fasiyal paralizi, Fasiyal sinir, Nötrofil Lenfosit Oranı (NLR), Sistemik İmmün-İnflamasyon İndeksi (SII)

THE ROLE AND ASSESSMENT OF SYSTEMIC IMMUNE-INFLAMMATION INDEX AS A NOVEL INFLAMMATORY MARKER IN PERIPHERAL AND CENTRAL FACIAL PARALYSIS

Abstract

Systemic immune-inflammation index (SII) is a novel inflammatory marker and is commonly used in clinical management such as prognosis and response to therapies. In this study, the outcomes and correlations of inflammatory markers in central and peripheral facial paralysis were evaluated. The study was planned retrospectively and cross-sectionally. Totally 133 patients (group 1; 53, group 2; 80) were included in the study. The neutrophil counts were 4.7 ± 1.6 and 3.7 ± 1.6 (p=0.001), and the lymphocyte counts were 2.8 ± 0.8 and 3.3 ± 1 (p=0.007) in groups 1 and 2, respectively. While Neutrophil lymphocyte ratio (NLR) was 1.8 ± 0.9 in patients with central facial paralysis, NLR was analysed as 1.4 ± 1 in patients with peripheral facial paralysis (p=0.001). Systemic immune-inflammation index was determined as 529.5 ± 297.4 in the first group and 408.2 ± 228.1 in the second group (p=0.029). There was a positive correlation between NLR and SII (r:0.787, p<0.001). Peripheral facial paralysis was evaluated according to the H-B scale [(median:3, min-max:2-6)]. In conclusion, an elevated level of inflammatory markers was remarkable in pathologies affecting the central nervous system. NLR and SII values were increased in central facial paralysis.

Keywords

Inflammation, Facial nerve, Facial paralysis, Neutrophil Lymphocyte Ratio (NLR), Systemic Immune-Inflammation Index (SII)

Thanks

Infinite gratitude and regards to Dr. Nusret Ayaz, graduate of Uludag University Faculty of Medicine, 2010

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