miRNA’LAR VE KORONER ARTER HASTALIKLARIYLA İLİŞKİLERİ

Year 2020, , 162 - 174, 26.04.2020

Reşat Dikme , Mahmut Padak , Ezhar Korkmaz Ersöz Yasemin Hacanlı

https://doi.org/10.33715/inonusaglik.700995

Abstract

Son çalışmalar, miRNA'ların kalbin gelişimi ve düzgün çalışması için çok önemli olduğunu göstermiştir. Kalbin kardiyojenik transkripsiyon faktörleri nedeniyle ifade edilen birçok miRNA'sı vardır. Kardiyovasküler hastalıklar sırasında miRNA ekspresyonu önemli ölçüde değişir ve farklı miRNA ekspresyon seviyeleri spesifik kardiyovasküler bozukluklarla korelasyon gösterir. Bu derleme makalesi miRNA'lar hakkında ayrıntılı bilgi vererek hem klinik hem de subklinik koroner arter hastalığı ile korelasyonu hakkındaki mevcut kanıtları özetlemekte, ayrıca miRNA'ların koroner arter hastalığında potansiyel bir tanı ve prognostik biyobelirteç olarak araştırmanın gerekliliğini vurgulamaktadır.

Keywords

mikroRNA, miRNA, Koroner arter hastalığı

Relations of mirna's and Coronary Artery Diseases

Abstract

Recent studies have established that miRNAs are crucial for the development and proper functioning of the heart. The heart has many miRNAs expressed due to cardiogenic transcription factors. During cardiovascular diseases, miRNA expression varies significantly and different miRNA expression levels are correlated with specific cardiovascular disorders. This review article provides detailed information about miRNAs, summarizes the available evidence on the correlation of micro-RNAs with both the clinical and subclinical coronary artery disease and highlights the necessity for exploring miRNAs as a potential diagnostic and prognostic biomarker of early CAD. 

Keywords

microRNA, coronary artery disease

References

• Arşiv Kaynak Tarama Dergisi. Archives Medical Review Journal 2015;24(4):472-493.
• Barbarotto, E., Schmittgen, T. D., & Calin, G. A. (2008). MicroRNAs and cancer: Profile, profile, profile. In International Journal of Cancer. https://doi.org/10.1002/ijc.23343
• Bissels, U., Bosio, A., & Wagner, W. (2012). MicroRNAs are shaping the hematopoietic landscape. In Haematologica. https://doi.org/10.3324/haematol.2011.051730
• Borchert, G. M., Lanier, W., & Davidson, B. L. (2006). RNA polymerase III transcribes human microRNAs. Nature Structural and Molecular Biology. https://doi.org/10.1038/nsmb1167
• Broderick, J. A., & Zamore, P. D. (2011). MicroRNA therapeutics. In Gene Therapy. https://doi.org/10.1038/gt.2011.50
• Curtis, H. J., Sibley, C. R., & Wood, M. J. A. (2012). Mirtrons, an emerging class of atypical miRNA. In Wiley Interdisciplinary Reviews: RNA. https://doi.org/10.1002/wrna.1122
• Dai, G. H., Ma, P. Z., Song, X. B., Liu, N., Zhang, T., & Wu, B. (2014). MicroRNA-223-3p inhibits the angiogenesis of ischemic cardiac microvascular endothelial cells via affecting RPS6KB1/hif-1a signal pathway. PLoS ONE. https://doi.org/10.1371/journal.pone.0108468
• Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004). Processing of primary microRNAs by the Microprocessor complex. Nature. https://doi.org/10.1038/nature03049
• Fernandez, A. L., Garcia-Bengochea, J. B., Alvarez, J., & Gonzalez Juanatey, J. R. (2008). Biochemical markers of myocardial injury in the pericardial fluid of patients undergoing heart surgery. Interactive CardioVascular and Thoracic Surgery. https://doi.org/10.1510/icvts.2007.168302
• Fiorucci, G., V. Chiantore, M., Mangino, G., A. Percario, Z., Affabris, E., & Romeo, G. (2012). Cancer Regulator MicroRNA: Potential Relevance in Diagnosis, Prognosis and Treatment of Cancer. Current Medicinal Chemistry. https://doi.org/10.2174/092986712798918798
• Freedman, J. E., Ercan, B., Morin, K. M., Liu, C. T., Tamer, L., Ayaz, L., Kanadasi, M., Cicek, D., Seyhan, A. I., Akilli, R. E., Camci, C., Cengiz, B., Oztuzcu, S., & Tanriverdi, K. (2012). The distribution of circulating microRNA and their relation to coronary disease. F1000Research. https://doi.org/10.12688/f1000research.1-50.v1
• Garzon, R., Calin, G. A., & Croce, C. M. (2009). MicroRNAs in Cancer. Annual Review of Medicine. https://doi.org/10.1146/annurev.med.59.053006.104707
• Großhans, H., & Chatterjee, S. (2010). MicroRNases and the regulated degradation of mature animal miRNAs. Advances in Experimental Medicine and Biology. https://doi.org/10.1007/978-1-4419-7823-3_12
• Güzelgül, F., & Aksoy, K. (2015). Bir Gen İfade Düzenleyicisi miRNA. Arşiv Kaynak Tarama Dergisi. https://doi.org/10.17827/aktd.95263
• He, L., & Hannon, G. J. (2004). MicroRNAs: Small RNAs with a big role in gene regulation. In Nature Reviews Genetics. https://doi.org/10.1038/nrg1379
• Kaikkonen, M. U., Lam, M. T. Y., & Glass, C. K. (2011). Non-coding RNAs as regulators of gene expression and epigenetics. In Cardiovascular Research. https://doi.org/10.1093/cvr/cvr097
• Kalozoumi, G., Yacoub, M., & Sanoudou, D. (2014). MicroRNAs in heart failure: Small molecules with major impact. Global Cardiology Science and Practice. https://doi.org/10.5339/gcsp.2014.30
• Ke, X. S., Liu, C. M., Liu, D. P., & Liang, C. C. (2003). MicroRNAs: Key participants in gene regulatory networks. In Current Opinion in Chemical Biology. https://doi.org/10.1016/S1367-5931(03)00075-9
• Klimczak, D., Paczek, L., Jazdzewski, K., & Kuch, M. (2015). MicroRNAs: Powerful regulators and potential diagnostic tools in cardiovascular disease. In Kardiologia Polska. https://doi.org/10.5603/KP.a2014.0210
• Krützfeldt, J., & Stoffel, M. (2006). MicroRNAs: A new class of regulatory genes affecting metabolism. In Cell Metabolism. https://doi.org/10.1016/j.cmet.2006.05.009
• Kuosmanen, S. M., Hartikainen, J., Hippeläinen, M., Kokki, H., Levonen, A. L., & Tavi, P. (2015). MicroRNA profiling of pericardial fluid samples from patients with heart failure. PLoS ONE. https://doi.org/10.1371/journal.pone.0119646
• Kwak, P. B., Iwasaki, S., & Tomari, Y. (2010). The microRNA pathway and cancer. In Cancer Science. https://doi.org/10.1111/j.1349-7006.2010.01683.x
• Lässer, C., O’Neil, S. E., Ekerljung, L., Ekström, K., Sjöstrand, M., & Lötvall, J. (2011). RNA-containing exosomes in human nasal secretions. American Journal of Rhinology and Allergy. https://doi.org/10.2500/ajra.2011.25.3573
• Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. https://doi.org/10.1016/0092-8674(93)90529-Y
• Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O., Kim, S., & Kim, V. N. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature. https://doi.org/10.1038/nature01957
• Lee, Y., Kim, M., Han, J., Yeom, K. H., Lee, S., Baek, S. H., & Kim, V. N. (2004). MicroRNA genes are transcribed by RNA polymerase II. EMBO Journal. https://doi.org/10.1038/sj.emboj.7600385
• Leopold, J. (2014). MicroRNAs Regulate Vascular Medial Calcification. Cells. https://doi.org/10.3390/cells3040963
• Maitrias, P., Metzinger-Le Meuth, V., Massy, Z. A., M’Baya-Moutoula, E., Reix, T., Caus, T., & Metzinger, L. (2015). MicroRNA deregulation in symptomatic carotid plaque Presented at the Controversies and Updates in Vascular Surgery Congress, Paris, France, January 22-24, 2015. Journal of Vascular Surgery. https://doi.org/10.1016/j.jvs.2015.06.136
• Park, N. J., Zhou, H., Elashoff, D., Henson, B. S., Kastratovic, D. A., Abemayor, E., & Wong, D. T. (2009). Salivary microRNA: Discovery, characterization, and clinical utility for oral cancer detection. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-09-0736
• Rotllan, N., & Fernández-Hernando, C. (2012). MicroRNA regulation of cholesterol metabolism. In Cholesterol. https://doi.org/10.1155/2012/847849
• Rottiers, V., & Näär, A. M. (2012). MicroRNAs in metabolism and metabolic disorders. In Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3313
• Saito, T., & Sætrom, P. (2010). MicroRNAs - targeting and target prediction. In New Biotechnology. https://doi.org/10.1016/j.nbt.2010.02.016
• Saito, Y., Liang, G., Egger, G., Friedman, J. M., Chuang, J. C., Coetzee, G. A., & Jones, P. A. (2006). Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. https://doi.org/10.1016/j.ccr.2006.04.020
• Taft, R. J., Pheasant, M., & Mattick, J. S. (2007). The relationship between non-protein-coding DNA and eukaryotic complexity. In BioEssays. https://doi.org/10.1002/bies.20544
• Thum, T., Galuppo, P., Wolf, C., Fiedler, J., Kneitz, S., Van Laake, L. W., Doevendans, P. A., Mummery, C. L., Borlak, J., Haverich, A., Gross, C., Engelhardt, S., Ertl, G., & Bauersachs, J. (2007). MicroRNAs in the human heart: A clue to fetal gene reprogramming in heart failure. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.107.687947
• Treiber, T., Treiber, N., & Meister, G. (2012). Regulation of microRNA biogenesis and function. In Thrombosis and Haemostasis. https://doi.org/10.1160/th11-12-0836
• Van Rooij, E., & Olson, E. N. (2007). MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets. In Journal of Clinical Investigation. https://doi.org/10.1172/JCI33099
• Wang, F., Chen, C., & Wang, D. (2014). Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets. In Frontiers of Medicine. https://doi.org/10.1007/s11684-014-0379-2
• Wang, J., Pei, Y., Zhong, Y., Jiang, S., Shao, J., & Gong, J. (2014). Altered serum microRNAs as novel diagnostic biomarkers for atypical coronary artery disease. PLoS ONE. https://doi.org/10.1371/journal.pone.0107012
• Westholm, J. O., & Lai, E. C. (2011). Mirtrons: MicroRNA biogenesis via splicing. In Biochimie. https://doi.org/10.1016/j.biochi.2011.06.017
• Widmer, R. J., Chung, W. Y., Herrmann, J., Jordan, K. L., Lerman, L. O., & Lerman, A. (2014). The association between circulating MicroRNA levels and coronary endothelial function. PLoS ONE. https://doi.org/10.1371/journal.pone.0109650
• Xiao, Y. F., Yong, X., Fan, Y. H., Lü, M. H., Yang, S. M., & Hu, C. J. (2013). microRNA detection in feces, sputum, pleural effusion and urine: Novel tools for cancer screening (Review). In Oncology Reports. https://doi.org/10.3892/or.2013.2525