PREPARATION OF ALLANTOIN LOADED CHITOSAN NANOPARTICLES AND INFLUENCE OF MOLECULAR WEIGHT OF CHITOSAN ON DRUG RELEASE

Year 2020, Volume: 8 Issue: 3, 725 - 740, 30.11.2020

Ahmet Ulu

https://doi.org/10.33715/inonusaglik.759872

Cited By: 3

Abstract

In this study, allantoin-loaded chitosan nanoparticles were prepared and the effect of molecular weights (low, medium, and high) of chitosan was investigated on the release of allantoin. The allantoin-loaded chitosan nanoparticles were characterized by various methods. The morphology, size, zeta potential, and loading efficiency were affected by the molecular weight of chitosan. The results displayed that the average hydrodynamic diameter of chitosan nanoparticles was in the range of 427–768 nm and the zeta potential values from 5.97 to 5.12 mV was obtained. The allantoin release from chitosan nanoparticles reached the plateau level in 96 hours. Cumulative allantoin release values of low, medium, and high molecular mass chitosan nanoparticles were determined as 43%, 30%, and 27%, respectively. According to the results, the molecular weight of chitosan influenced on allantoin release.

Keywords

Allantoin, Chitosan Nanoparticles, Drug Release, Moleculer Weights

Thanks

The author thanks Prof. Dr. Burhan Ateş.

Allantoin Yüklü Kitosan Nanopartiküllerinin Hazırlanması ve Kitosanın Moleküler Ağırlığının İlaç Salımı Üzerindeki Etkisi

Abstract

Bu çalışmada, allantoin yüklü kitosan nanopartikülleri hazırlanmış ve kitosanın moleküler ağırlıklarının (düşük, orta ve yüksek) allantoin salınımı üzerindeki etkisi araştırılmıştır. Allantoin yüklü kitosan nanopartikülleri çeşitli yöntemlerle karakterize edilmiştir. Morfoloji, boyut, zeta potansiyeli ve yükleme etkinliği, kitosanın moleküler ağırlığından etkilenmiştir. Sonuçlar, kitosan nanopartiküllerinin ortalama hidrodinamik çapının 427-768 nm aralığında olduğunu ve 5.97 ila 5.12 mV'lik zeta potansiyelinin elde edildiğini göstermiştir. Kitosan nanopartiküllerinden allantoin salınımı 96 saat içinde plato seviyesine ulaşmıştır. Kümülatif allantoin salım değerleri düşük, orta ve yüksek molekül ağırlıklı kitosan nanopartikülleri için sırasıyla %43, %30 ve % 27 olarak tespit edilmiştir. Sonuçlara göre kitosanın molekül ağırlığı allantoin salınımını etkilemiştir.

Keywords

Allantoin, İlaç Salınımı, Kitosan Nanopartiküller, Moleküler Ağırlığı

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