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EVALUATION OF SLEEP QUALITY IN PATIENTS WITH THYROID DISEASE

Year 2025, Volume: 13 Issue: 3, 551 - 566

Abstract

Sleep is a vital process for human health, and disturbances in sleep quality can be associated with various physical and mental illnesses. Thyroid dysfunctions, especially hyperthyroidism and hypothyroidism, can affect metabolic processes and lead to sleep quality disruptions. This study aims to evaluate sleep quality in patients with thyroid dysfunctions, focusing on the effects of hyperthyroidism and hypothyroidism on sleep initiation, duration, and disturbances, as well as their impact on patients' quality of life. Additionally, it seeks to explore the relationship between thyroid dysfunctions and sleep disorders, raising awareness of this connection. The study was conducted as a descriptive research involving 52 patients diagnosed with hyperthyroidism or hypothyroidism at Gaziantep University Şahinbey Research and Application Hospital's Endocrinology Clinic between January and May 2024. Data were collected using a "Socio-Demographic Information Form" and the "Basic Scale for Sleep Complaints and Sleep Quality." Statistical analyses, including t-tests and ANOVA, were used to identify differences between groups. The results revealed that sleep disorders are common in individuals with thyroid dysfunctions, particularly showing a significant decline in sleep quality related to difficulties in falling asleep, altered sleep duration, and socio-demographic factors.

References

  • Ağaryapılang South Korean Adults”. Journal of Health Informatics and Statistics 46(3):337-43. doi: 10.21032/jhis.2021.46.3.337.
  • Allen Gomes, Ana, Daniel Ruivo Marques, Ana Maria Meia-Via, Mariana Meia-Via, José Tavares, Carlos Fernandes da Silva, ve Maria Helena Pinto de Azevedo. 2015. “Basic Scale on Insomnia complaints and Quality of Sleep (BaSIQS): Reliability, initial validity and normative scores in higher education students”. Chronobiology International 32(3):428-40. doi: 10.3109/07420528.2014.986681.
  • Alreshidi, Nahlah Fahad, Hialah Alenzi, Rasha Alrashidi, Luluh Zamil Aljaloud, ve Alhanouf Bander Alshammari. 2024. “The Relationship Between Thyroid Dysfunction and Sleep Quality Among Population of Saudi Arabia”. International Journal of General Medicine 17:2497-2505. doi: 10.2147/IJGM.S462512.
  • Arosemena, M. A., Ramos, A. R., Marcus, E. N., Slota, K. A., Cheung, J., & Castillo, P. R. (2022). Primary hypothyroidism and chronotypes in adult women. BMC Research Notes, 15, 52. https://doi.org/10.1186/s13104-022-05934-3
  • Arpınar S., M., (2020). Sosyo demografik özelliklerin uyku kalitesine etkisine yönelik bir çalışma. Balkan ve Yakın Doğu Sosyal Bilimler Dergisi, 6(1), 144-157
  • Ayık, S., Apaydın, M., Aksun, S., Akhan, G., & Bahçeci, M. (2014). Obstrüktif uyku apne sendromlu olgularda hipotiroidi. Dicle Tıp Dergisi, 41(3), 512-517.
  • Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M…..L. C. (2019). Paradigms of dynamic control of thyroid hormone signaling. Endocrine Reviews, 40(4), 1000-1047. https://doi.org/10.1210/er.2018-00275
  • Birol L, Olgun N, Çelik S, (2020). “Endokrin Sistemi Hastalıkları ve Hemşirelik Bakımı”. Ss. 893-969 içinde İç Hastalıkları ve Hemşirelik Bakımı. Ankara: Akademisyen Yayınevi.
  • Consensus Conference Panel, Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., Malhotra, R. K., Martin, J. L., Patel, S. R., Quan, S. F., & Tasali, E. (2015).
  • Joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society on the recommended amount of sleep for a healthy adult: Methodology and discussion. Sleep, 38(8), 1161-1183.
  • Durgun, Zafer, Cemşah Yazıcı, ve Ali Osman İnan. 2019. “Tiroit Hormonları ve Hastalıkları”. Akdeniz Spor Bilimleri Dergisi 2(1):28-40.
  • Green, J. B., Bernet, V., & Cheung, K. L. (2021). Thyroid dysfunction and its impact on sleep disorders: A review of current literature. Journal of Endocrine Research, 36(4), 275-290.
  • Gözel N., Kılınç F.ve Demircan F., (2014). “Unilateral Graves hastalığı: Olgu sunumu.” 19(1):46-48.
  • Jensen, Esther, Ole Blaabjerg, Per Hyltoft Petersen, ve Laszlo Hegedüs. 2007. “Sampling Time Is Important but May Be Overlooked in Establishment and Use of Thyroid-Stimulating Hormone Reference Intervals”. Clinical Chemistry 53(2):355-56. doi: 10.1373/clinchem.2006.078964.
  • Kim, W., Lee, J., Ha, J., Jo, K., Lim, D.-J., Lee, J.-M., Chang, S.-A., Kang, M.-I., & Kim, M.-H. (2019). Association between sleep duration and subclinical thyroid dysfunction based on nationally representative data. Journal of Clinical Medicine, 8(11), 2010. https://doi.org/10.3390/jcm8112010
  • Koyuncuoğlu, Gül, E., Karaca, F., Alagöz,İ., Y., Kuru, F. & Koç., V., M. (t.y). “Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesindeki Tiroid Hastalarının Uyku Kalitesinin ve Durumunun Değerlendirilmesi”.
  • Mılıçoğlu, İ., Malakçıoğlu, C. & Mutlu H., H. (2021). Uykusuzluk şikâyetleri ve uyku kalitesi temel ölçeğinin türkçe geçerlilik ve güvenirliği. Türk Aile Hekimliği Ve Birinci Basamak Dergisi, 15(4), 846-852 doı: 10.21763/tjfmpc.971532.
  • Miller-Mendes, M., Gomes, A. A., Marques, D. R., Clemente, V., & Pintode Azevedo, M. H. (2019). BaSIQS - Basic scale on insomnia complaints and quality of sleep: Reliability, norms, validity, and accuracy studies, based on clinical and community samples. Chronobiology International, 36(5), 644-656.
  • Montaruli, A., Castelli L., Mulè A., Scurati R., Esposito F., Galasso L, & Roveda E. 2021. “Biological Rhythm and Chronotype: New Perspectives in Health”. Biomolecules 11(4):487. doi: 10.3390/biom11040487.
  • Nazem, Reza M., Bastanhagh, E., Emami, A., Hedayati, M., Samimi, S.& Karami, M. (2021). “The relationship between thyroid function tests and sleep quality: cross-sectional study”. Sleep Science 14(3):196-200. doi: 10.5935/1984-0063.20200050.
  • Okutan, A. (2018). Sağlık çalışanlarında uyku kalitesi ve yorgunluğun değerlendirilmesi. [Yüksek lisans tezi]. Yüksek Öğretim Kurulu Ulusal Tez Merkezi. (Tez No: 516042).
  • Mourad, O., Hammady, H., Fedorowicz, F. & Elmagarmid, A. (2016). “Rayyan—a web and mobile app for systematic reviews”. Systematic Reviews 5(1):210. doi: 10.1186/s13643-016-0384-4.
  • Saygın, M. & Özgüner, M. (2020). “Uykunun Mikro Yapısı ve Mimarisi”. Uyku Bülteni 1(1):19-29.
  • Stern, Robert, B. Robinson, A. Thorner, James Arruda, M. Prohaska, & A. R. Prange. (1996). “A survey study of neuropsychiatric complaints in patients with Graves’ disease”. The Journal of neuropsychiatry and clinical neurosciences 8:181-85. doi: 10.1176/jnp.8.2.181.
  • Suna, G. (2016). Üniversite öğrencilerinde uyku kalitesi ve yeme davranışının değerlendirilmesi. [Yüksek lisans tezi]. Yüksek Öğretim Kurulu Ulusal Tez Merkezi. (Tez No: 435818).
  • Vijaya Krishnan, S., Senthil Vadivu, S., Ashish Alappatt, G. & Kameswaran, M. (2012). “Prevalence of sleep abnormalities and their association among hypothyroid patients in an Indian population”. Sleep Medicine 13(10):1232-37. doi: 10.1016/j.sleep.2012.07.006.
  • Yan, Yuerong, Jiaqi Li, Huairong Tang, Youjuan Wang, Weiwei Zhang, Hui Liu, Leilei Zhu, Zhen Xiao, Hailing Yang, & Yerong Yu. (2022). “Elevated Thyroid-Stimulating Hormone Levels Are Associated with Poor Sleep: A Cross-Sectional and Longitudinal Study”. Endocrine 75(1):194-201. doi: 10.1007/s12020-021-02849-0.
  • Yen, P. M. (2001). “Physiological and Molecular Basis of Thyroid Hormone Action”. Physiological Reviews 81(3):1097-1142. doi: 10.1152/physrev.2001.81.3.1097.

EVALUATION OF SLEEP QUALITY IN PATIENTS WITH THYROID DISEASE

Year 2025, Volume: 13 Issue: 3, 551 - 566

Abstract

This study aimed to assess sleep quality in patients with thyroid dysfunction and to investigate the effects of hyperthyroidism and hypothyroidism on sleep onset, sleep duration, and sleep disturbances. Additionally, it seeks to determine the impact of these disorders on quality of life and raise awareness about the relationship between thyroid function and sleep. The research was conducted as a descriptive study on 52 patients diagnosed with hyperthyroidism or hypothyroidism in the endocrinology polyclinic of a state hospital between January 1 and May 31, 2024. Data were collected using the "Introductory Characteristics Information Form" and the "Insomnia Complaints and Sleep Quality Basic Scale." t-test and ANOVA were used for the statistical analysis of differences between the groups. The results indicate that, in individuals with thyroid dysfunction, sleep disorders are prevalent, particularly regarding sleep onset and changes in duration. The sample size was limited, and it is therefore recommended that the study be repeated in larger populations and that thyroid hormones’ impact on sleep and potential intervention strategies be evaluated.

References

  • Ağaryapılang South Korean Adults”. Journal of Health Informatics and Statistics 46(3):337-43. doi: 10.21032/jhis.2021.46.3.337.
  • Allen Gomes, Ana, Daniel Ruivo Marques, Ana Maria Meia-Via, Mariana Meia-Via, José Tavares, Carlos Fernandes da Silva, ve Maria Helena Pinto de Azevedo. 2015. “Basic Scale on Insomnia complaints and Quality of Sleep (BaSIQS): Reliability, initial validity and normative scores in higher education students”. Chronobiology International 32(3):428-40. doi: 10.3109/07420528.2014.986681.
  • Alreshidi, Nahlah Fahad, Hialah Alenzi, Rasha Alrashidi, Luluh Zamil Aljaloud, ve Alhanouf Bander Alshammari. 2024. “The Relationship Between Thyroid Dysfunction and Sleep Quality Among Population of Saudi Arabia”. International Journal of General Medicine 17:2497-2505. doi: 10.2147/IJGM.S462512.
  • Arosemena, M. A., Ramos, A. R., Marcus, E. N., Slota, K. A., Cheung, J., & Castillo, P. R. (2022). Primary hypothyroidism and chronotypes in adult women. BMC Research Notes, 15, 52. https://doi.org/10.1186/s13104-022-05934-3
  • Arpınar S., M., (2020). Sosyo demografik özelliklerin uyku kalitesine etkisine yönelik bir çalışma. Balkan ve Yakın Doğu Sosyal Bilimler Dergisi, 6(1), 144-157
  • Ayık, S., Apaydın, M., Aksun, S., Akhan, G., & Bahçeci, M. (2014). Obstrüktif uyku apne sendromlu olgularda hipotiroidi. Dicle Tıp Dergisi, 41(3), 512-517.
  • Bianco, A. C., Dumitrescu, A., Gereben, B., Ribeiro, M. O., Fonseca, T. L., Fernandes, G. W., & Bocco, B. M…..L. C. (2019). Paradigms of dynamic control of thyroid hormone signaling. Endocrine Reviews, 40(4), 1000-1047. https://doi.org/10.1210/er.2018-00275
  • Birol L, Olgun N, Çelik S, (2020). “Endokrin Sistemi Hastalıkları ve Hemşirelik Bakımı”. Ss. 893-969 içinde İç Hastalıkları ve Hemşirelik Bakımı. Ankara: Akademisyen Yayınevi.
  • Consensus Conference Panel, Watson, N. F., Badr, M. S., Belenky, G., Bliwise, D. L., Buxton, O. M., Buysse, D., Dinges, D. F., Gangwisch, J., Grandner, M. A., Kushida, C., Malhotra, R. K., Martin, J. L., Patel, S. R., Quan, S. F., & Tasali, E. (2015).
  • Joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society on the recommended amount of sleep for a healthy adult: Methodology and discussion. Sleep, 38(8), 1161-1183.
  • Durgun, Zafer, Cemşah Yazıcı, ve Ali Osman İnan. 2019. “Tiroit Hormonları ve Hastalıkları”. Akdeniz Spor Bilimleri Dergisi 2(1):28-40.
  • Green, J. B., Bernet, V., & Cheung, K. L. (2021). Thyroid dysfunction and its impact on sleep disorders: A review of current literature. Journal of Endocrine Research, 36(4), 275-290.
  • Gözel N., Kılınç F.ve Demircan F., (2014). “Unilateral Graves hastalığı: Olgu sunumu.” 19(1):46-48.
  • Jensen, Esther, Ole Blaabjerg, Per Hyltoft Petersen, ve Laszlo Hegedüs. 2007. “Sampling Time Is Important but May Be Overlooked in Establishment and Use of Thyroid-Stimulating Hormone Reference Intervals”. Clinical Chemistry 53(2):355-56. doi: 10.1373/clinchem.2006.078964.
  • Kim, W., Lee, J., Ha, J., Jo, K., Lim, D.-J., Lee, J.-M., Chang, S.-A., Kang, M.-I., & Kim, M.-H. (2019). Association between sleep duration and subclinical thyroid dysfunction based on nationally representative data. Journal of Clinical Medicine, 8(11), 2010. https://doi.org/10.3390/jcm8112010
  • Koyuncuoğlu, Gül, E., Karaca, F., Alagöz,İ., Y., Kuru, F. & Koç., V., M. (t.y). “Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesindeki Tiroid Hastalarının Uyku Kalitesinin ve Durumunun Değerlendirilmesi”.
  • Mılıçoğlu, İ., Malakçıoğlu, C. & Mutlu H., H. (2021). Uykusuzluk şikâyetleri ve uyku kalitesi temel ölçeğinin türkçe geçerlilik ve güvenirliği. Türk Aile Hekimliği Ve Birinci Basamak Dergisi, 15(4), 846-852 doı: 10.21763/tjfmpc.971532.
  • Miller-Mendes, M., Gomes, A. A., Marques, D. R., Clemente, V., & Pintode Azevedo, M. H. (2019). BaSIQS - Basic scale on insomnia complaints and quality of sleep: Reliability, norms, validity, and accuracy studies, based on clinical and community samples. Chronobiology International, 36(5), 644-656.
  • Montaruli, A., Castelli L., Mulè A., Scurati R., Esposito F., Galasso L, & Roveda E. 2021. “Biological Rhythm and Chronotype: New Perspectives in Health”. Biomolecules 11(4):487. doi: 10.3390/biom11040487.
  • Nazem, Reza M., Bastanhagh, E., Emami, A., Hedayati, M., Samimi, S.& Karami, M. (2021). “The relationship between thyroid function tests and sleep quality: cross-sectional study”. Sleep Science 14(3):196-200. doi: 10.5935/1984-0063.20200050.
  • Okutan, A. (2018). Sağlık çalışanlarında uyku kalitesi ve yorgunluğun değerlendirilmesi. [Yüksek lisans tezi]. Yüksek Öğretim Kurulu Ulusal Tez Merkezi. (Tez No: 516042).
  • Mourad, O., Hammady, H., Fedorowicz, F. & Elmagarmid, A. (2016). “Rayyan—a web and mobile app for systematic reviews”. Systematic Reviews 5(1):210. doi: 10.1186/s13643-016-0384-4.
  • Saygın, M. & Özgüner, M. (2020). “Uykunun Mikro Yapısı ve Mimarisi”. Uyku Bülteni 1(1):19-29.
  • Stern, Robert, B. Robinson, A. Thorner, James Arruda, M. Prohaska, & A. R. Prange. (1996). “A survey study of neuropsychiatric complaints in patients with Graves’ disease”. The Journal of neuropsychiatry and clinical neurosciences 8:181-85. doi: 10.1176/jnp.8.2.181.
  • Suna, G. (2016). Üniversite öğrencilerinde uyku kalitesi ve yeme davranışının değerlendirilmesi. [Yüksek lisans tezi]. Yüksek Öğretim Kurulu Ulusal Tez Merkezi. (Tez No: 435818).
  • Vijaya Krishnan, S., Senthil Vadivu, S., Ashish Alappatt, G. & Kameswaran, M. (2012). “Prevalence of sleep abnormalities and their association among hypothyroid patients in an Indian population”. Sleep Medicine 13(10):1232-37. doi: 10.1016/j.sleep.2012.07.006.
  • Yan, Yuerong, Jiaqi Li, Huairong Tang, Youjuan Wang, Weiwei Zhang, Hui Liu, Leilei Zhu, Zhen Xiao, Hailing Yang, & Yerong Yu. (2022). “Elevated Thyroid-Stimulating Hormone Levels Are Associated with Poor Sleep: A Cross-Sectional and Longitudinal Study”. Endocrine 75(1):194-201. doi: 10.1007/s12020-021-02849-0.
  • Yen, P. M. (2001). “Physiological and Molecular Basis of Thyroid Hormone Action”. Physiological Reviews 81(3):1097-1142. doi: 10.1152/physrev.2001.81.3.1097.
There are 28 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases Nursing​
Journal Section Araştırma Makalesi
Authors

Dilan Bilbay 0009-0001-8949-1031

Nermin Olgun 0000-0002-8704-4588

Early Pub Date October 6, 2025
Publication Date October 10, 2025
Submission Date November 3, 2024
Acceptance Date June 23, 2025
Published in Issue Year 2025 Volume: 13 Issue: 3

Cite

APA Bilbay, D., & Olgun, N. (2025). EVALUATION OF SLEEP QUALITY IN PATIENTS WITH THYROID DISEASE. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 13(3), 551-566.