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Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo

Year 2013, Volume: 6 Issue: 1, 1 - 5, 01.03.2013

Zana Sllamnikudalipi Fatmir Dragidella Metush Disha Kastriot Meqa Luljeta Begolli Gramos Begolli

Abstract

The possibility of a connection between oral cavity and systemic diseases has been intensively researched in recent years. The aim of this study was to compare the serum levels of highsensitivity C reactive protein (hs-CRP), interleukin-1 beta (IL1β), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNFα) between patients with and without periodontitis. Clinical periodontal parameters: gingival index, the dental plaque index, the probing depth, the clinical attachment level, the bleeding index and the tooth mobility index were measured at six sites per tooth in seventy-five subjects with periodontitis and in thirty-five periodontally healthy subjects. Serum levels of hs-CRP and inflammatory cytokines were assessed via Enzyme-Linked ImmunoSorbent Assay. Inter-group significance was determined by the Student’s t-test, x2-test and Mann-Whitney test. The concentrations of each biomarker (control group vs. periodontal disease group) were as follows: hsCRP (0.5 ± 0.6 vs. 2.5 ± 2.6, respectively), IL-1β (2.1 ± 2.2 vs. 7.0 ± 11.6, respectively), IL- 6 (1.9 ± 1.6 vs. 3.7 ± 4.4, respectively) and TNF- α (64.6 ± 72.3 vs. 80.0 ± 73.1, respectively). The differences between the groups showed statistical significance at p < 0.05. Periodontal disease was associated with increased circulating concentrations of hs-CRP and inflammatory cytokines. Clinical article (J Int Dent Med Res 2013; 6: (1), pp. 1-5)

Keywords

Periodontal disease interleukin–1 beta interleukin–6 tumour necrosis factor alpha high sensitivity- C reactive protein.

References

  • Williams RC, Offenbacher S: Periodontal medicine: The emergency of a new branch of periodontology. Periodontol 2000 2000;23:9-12.
  • Ebersole JL, Machen RL, Steffen MJ, Willmann DE: Systemic acute-phase reactants, C-reactive protein and haptoglobin in adult periodontitis. Clin Exp Immunol 1997; 107(2):347-352.
  • Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001; 72(9):1221-1227.
  • Kinnane DF, Lappin DF: Immune processes in periodontal disease : A review. Ann Periodontol 2001;7:62-71.
  • Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B: Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 2003; 24:2099-2107.
  • Craig RG, Yip JK, So MK, Boylan RJ, Socransky SS, Haffajee AD. Relationship of destructive periodontal disease to the acute- phase response. J Periodontol 2003;74:1007-1016.
  • Borden EC, Chin P: Interleukin 6: a cytokine with potential diagnostic and therapeutic roles. Journal of Laboratory and Clinical Medicine 1994;123:824-829.
  • Bradley JR: TNF- mediated inflammatory disease. J Pathol 2008;214:149-160.
  • Ebersole JL, Machen RL, Steffen MJ, Willmann DE: Systemic acute-phase reactants, C-reactive protein and hatoglobin in adult periodontitis. Clin Exp Immunol 1997; 107:347-352.
  • Loos BG: Systemic markers of inflammation in periodontitis. Journal of Periodontology 2005;76:2106-2115.
  • Loe H: The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610.
  • Silness P, Loe H: Periodontal disease in pregnancy. Acta Odontal Scand 1964;22:121.
  • Lopez NJ, Smith PC, Gutierrez S: Periodontal therapy may reduce risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J Periodontology 2001; 73:911-924.
  • Ridker PM, Morrow DA: C-reactive protein, inflammation, and coronary risk. Cardiol Clin 2003;21:315-325.
  • Beckman JA, Preis O, Ridker PM, Gerhard Herman M: Comparison of usefulness of inflammatory markers in patients with versus without peripheral arterial disease in predicting adverse cardiovascular outcomes (myocardial infarction, stroke and death). Am J Cardiol 2005;96:1374-1378.
  • Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infection contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72:1221-7.
  • Boucher NE Jr, Hanrahan JJ, Kihara FY: Occurrence of Creactive protein in oral disease. J Dent Res 1967;46:624.
  • Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S: Relationship between periodontal disease and C reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med 2003;163:1172-9.
  • Loos BG, Craandijik J, Hoek FJ, Wertheim –van Dillen PM, van der Velden U: Evaluation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71:1528-34.
  • Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35:277-290.
  • Engebreston SP, Lamster IB, Herrera- Abreu M, Celenti RS, Timms JM, Chaudhar AGA, Giovine F, Kornman KS: The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol 1999;70:5675
  • Hou LT, Liu CM, Rossomando EF: Cervicular interleukin 1 beta in moderate and severe periodontitis patients and the effect of phase I periodontal treatment. J Clin Periodontol 1995;22:1621
  • Marcaccini AM, Meschiari CA, Sorgi, Saraiva MCP, De Souza AM, Faccioli LH, Tanus-Santos J, Novaes AB, Gerlach RF: Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. J Periodontol 2009;80:594-602.
  • Persson GR, Pettersson T, Ohlsson O, Renvert S: Highsensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis. J Clin Periodontol 2005;32:219-224.
  • Albert MA: Race/ethnicity and inflammation- is there a link with periodontal disease? J Periodontol 2008;79:1121-3.

Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo

Year 2013, Volume: 6 Issue: 1, 1 - 5, 01.03.2013

Zana Sllamnikudalipi Fatmir Dragidella Metush Disha Kastriot Meqa Luljeta Begolli Gramos Begolli

Abstract

Keywords

-

References

  • Williams RC, Offenbacher S: Periodontal medicine: The emergency of a new branch of periodontology. Periodontol 2000 2000;23:9-12.
  • Ebersole JL, Machen RL, Steffen MJ, Willmann DE: Systemic acute-phase reactants, C-reactive protein and haptoglobin in adult periodontitis. Clin Exp Immunol 1997; 107(2):347-352.
  • Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infections contribute to elevated systemic C-reactive protein level. J Periodontol 2001; 72(9):1221-1227.
  • Kinnane DF, Lappin DF: Immune processes in periodontal disease : A review. Ann Periodontol 2001;7:62-71.
  • Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B: Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 2003; 24:2099-2107.
  • Craig RG, Yip JK, So MK, Boylan RJ, Socransky SS, Haffajee AD. Relationship of destructive periodontal disease to the acute- phase response. J Periodontol 2003;74:1007-1016.
  • Borden EC, Chin P: Interleukin 6: a cytokine with potential diagnostic and therapeutic roles. Journal of Laboratory and Clinical Medicine 1994;123:824-829.
  • Bradley JR: TNF- mediated inflammatory disease. J Pathol 2008;214:149-160.
  • Ebersole JL, Machen RL, Steffen MJ, Willmann DE: Systemic acute-phase reactants, C-reactive protein and hatoglobin in adult periodontitis. Clin Exp Immunol 1997; 107:347-352.
  • Loos BG: Systemic markers of inflammation in periodontitis. Journal of Periodontology 2005;76:2106-2115.
  • Loe H: The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610.
  • Silness P, Loe H: Periodontal disease in pregnancy. Acta Odontal Scand 1964;22:121.
  • Lopez NJ, Smith PC, Gutierrez S: Periodontal therapy may reduce risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J Periodontology 2001; 73:911-924.
  • Ridker PM, Morrow DA: C-reactive protein, inflammation, and coronary risk. Cardiol Clin 2003;21:315-325.
  • Beckman JA, Preis O, Ridker PM, Gerhard Herman M: Comparison of usefulness of inflammatory markers in patients with versus without peripheral arterial disease in predicting adverse cardiovascular outcomes (myocardial infarction, stroke and death). Am J Cardiol 2005;96:1374-1378.
  • Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E: Periodontal infection contribute to elevated systemic C-reactive protein level. J Periodontol 2001;72:1221-7.
  • Boucher NE Jr, Hanrahan JJ, Kihara FY: Occurrence of Creactive protein in oral disease. J Dent Res 1967;46:624.
  • Slade GD, Ghezzi EM, Heiss G, Beck JD, Riche E, Offenbacher S: Relationship between periodontal disease and C reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med 2003;163:1172-9.
  • Loos BG, Craandijik J, Hoek FJ, Wertheim –van Dillen PM, van der Velden U: Evaluation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000; 71:1528-34.
  • Paraskevas S, Huizinga JD, Loos BG. A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 2008;35:277-290.
  • Engebreston SP, Lamster IB, Herrera- Abreu M, Celenti RS, Timms JM, Chaudhar AGA, Giovine F, Kornman KS: The influence of interleukin gene polymorphism on expression of interleukin-1beta and tumor necrosis factor-alpha in periodontal tissue and gingival crevicular fluid. J Periodontol 1999;70:5675
  • Hou LT, Liu CM, Rossomando EF: Cervicular interleukin 1 beta in moderate and severe periodontitis patients and the effect of phase I periodontal treatment. J Clin Periodontol 1995;22:1621
  • Marcaccini AM, Meschiari CA, Sorgi, Saraiva MCP, De Souza AM, Faccioli LH, Tanus-Santos J, Novaes AB, Gerlach RF: Circulating interleukin-6 and high-sensitivity C-reactive protein decrease after periodontal therapy in otherwise healthy subjects. J Periodontol 2009;80:594-602.
  • Persson GR, Pettersson T, Ohlsson O, Renvert S: Highsensitivity serum C-reactive protein levels in subjects with or without myocardial infarction or periodontitis. J Clin Periodontol 2005;32:219-224.
  • Albert MA: Race/ethnicity and inflammation- is there a link with periodontal disease? J Periodontol 2008;79:1121-3.
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Zana Sllamnikudalipi This is me

Fatmir Dragidella This is me

Metush Disha This is me

Kastriot Meqa This is me

Luljeta Begolli This is me

Gramos Begolli This is me

Publication Date March 1, 2013
Published in Issue Year 2013 Volume: 6 Issue: 1

Cite

APA Sllamnikudalipi, Z., Dragidella, F., Disha, M., Meqa, K., et al. (2013). Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo. Journal Of International Dental And Medical Research, 6(1), 1-5.
AMA Sllamnikudalipi Z, Dragidella F, Disha M, Meqa K, Begolli L, Begolli G. Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo. JIDMR. March 2013;6(1):1-5.
Chicago Sllamnikudalipi, Zana, Fatmir Dragidella, Metush Disha, Kastriot Meqa, Luljeta Begolli, and Gramos Begolli. “Inflammatory Biomarkers As Potential Mediators for the Association Between Periodontal and Systemic Disease in Kosovo”. Journal Of International Dental And Medical Research 6, no. 1 (March 2013): 1-5.
EndNote Sllamnikudalipi Z, Dragidella F, Disha M, Meqa K, Begolli L, Begolli G (March 1, 2013) Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo. Journal Of International Dental And Medical Research 6 1 1–5.
IEEE Z. Sllamnikudalipi, F. Dragidella, M. Disha, K. Meqa, L. Begolli, and G. Begolli, “Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo”, JIDMR, vol. 6, no. 1, pp. 1–5, 2013.
ISNAD Sllamnikudalipi, Zana et al. “Inflammatory Biomarkers As Potential Mediators for the Association Between Periodontal and Systemic Disease in Kosovo”. Journal Of International Dental And Medical Research 6/1 (March 2013), 1-5.
JAMA Sllamnikudalipi Z, Dragidella F, Disha M, Meqa K, Begolli L, Begolli G. Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo. JIDMR. 2013;6:1–5.
MLA Sllamnikudalipi, Zana et al. “Inflammatory Biomarkers As Potential Mediators for the Association Between Periodontal and Systemic Disease in Kosovo”. Journal Of International Dental And Medical Research, vol. 6, no. 1, 2013, pp. 1-5.
Vancouver Sllamnikudalipi Z, Dragidella F, Disha M, Meqa K, Begolli L, Begolli G. Inflammatory Biomarkers as Potential Mediators for the Association between Periodontal and Systemic Disease in Kosovo. JIDMR. 2013;6(1):1-5.