Monocyte eosinophil ratio and red blood cell distribution width in the diagnosis of asthma

Abstract

Objective: Bronchial asthma is often associated with chronic airway inflammation and airway hyperresponsiveness in which many cells and mediators are involved. Pulmonary function tests (PFTs) are used in the diagnosis of the disease. Yet PFTs are not available in every healthcare institution or some of the patients cannot cooperate with the procedure. The aim of this study was to determine whether mean platelet volume (MPV), platelet distribution width (PDW), monocyte lymphocyte ratio (MLR), monocyte eosinophil ratio (MER), and platelet lymphocyte ratio (PLR) can be used in the diagnosis of bronchial asthma. Method: Two hundred and twelve patients who were diagnosed with bronchial asthma according to the Global Initiative for Asthma (GINA) criteria and 187 patients who were deemed not to have asthma were included in the study. Two patient groups were compared by examining the hemogram parameters at the time of diagnosis or exclusion of asthma. Results: The levels of MPV, neutrophil-lymphocyte ratio (NLR), and PLR were significantly lower in the Asthma group (p <0.001, 0.005, and 0.002 respectively) while the lymphocyte, eosinophil, monocyte, basophil, PDW, MLR, and MER levels were higher in the same group. On ROC analysis areas under the curve (AUC) for RDW, MER, and PDW were found as 0.81, 0.93, and 0.76 respectively. Conclusion: In conclusion, higher lymphocyte, eosinophil, PDW, MLR, and MER whereas lower levels of MPV, NLR and PLR support the diagnosis of asthma

Keywords

• Asthma
• Red Cell Distribution Width
• Monocyte
• Eosinophil

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