Evaluation of platelet indices in chronic kidney disease

Abstract

Objective: Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney functions and accumulation of uremic toxins in the body. Platelet indices have the potential to predict the inflammatory status and disease progression in patients with CKD. In this study it was aimed to investigate platelet indices and their relations with renal function and comorbid conditions in CKD patients. Method: In this study it was included 411 CKD patients. We looked for associations between platelet indices and estimated glomerular filtration rate (eGFR). We generated linear regression models for platelet indices that may be associated with eGFR. We evaluated CKD patients for possible associations between platelet indices and comorbid conditions such as diabetes, hypertension, and cardiovascular diseases. Results: The mean age of CKD patients was 60.5 and the GFR value was 40.1+24.8 mL/min/1.73m2. While the mean platelet count, MPV, PCT, PDW, P-LCR values were lower in the advanced CKD group, hematocrit adjusted platelet count (HAPC), MPV/Lymphocyte ratio and SII parameters were higher in the advanced CKD group (p<0.05 for all). In analyzes a positive correlation was detected between eGFR and HAPC, and a negative correlation was detected between MPV/Lymphocyte ratio and eGFR (p<0.001 and p=0.036). MPV, PCT, PDW, P-LCR and SII index were observed to be higher in diabetic CKD patients (p<0.05 for all). Conclusion: Platelet indices have the potential to provide valuable data about chronic diseases and their complications. MPV/Lymphocyte ratio and HAPC can give an idea about CKD progression. Our findings suggest that elevations in platelet volume indices could be indicative of diabetic nephropathy and increased inflammatory status.

Keywords

• Hematocrit adjusted platelet count
• mean platelet volume
• platelet indices
• systemic immune-inflamation index

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