The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience

Esra Erpek; Ayşegül Aksu; Hakan Abdullah Özgül; Ahmet Şeyhanlı; Özhan Özdoğan; Mustafa Seçil; Hayri Özsan

doi:10.17944/interdiscip.1726678

The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience

Abstract

Objective: This study aims to explore the relationship between interim imaging outcomes and disease prognosis in patients diagnosed with Hodgkin lymphoma (HL) and diffuse large B-cell lymphoma (DLBCL). Method: A total of 157 patients were retrospectively analyzed, comprising 90 with DLBCL and 67 with HL, who received follow-up at our institution. Interim and baseline PET/CT scans (I-PET/CT) from 121 patients were independently interpreted by two nuclear medicine specialists, blinded to clinical data. Additionally, 53 patients underwent both initial and interim contrast-enhanced computed tomography (I-CT), which was independently reviewed by two radiologists under blinded conditions. Results: Interim PET/CT findings were analyzed in relation to post-treatment outcomes to determine the predictive performance of the imaging modality. The positive predictive value (PPV) and negative predictive value (NPV) were calculated separately for HL and DLBCL. In HL cases, I-PET/CT demonstrated a PPV of 36% and an NPV of 95.4%, while in DLBCL, the respective values were 61.9% and 93.1%. Notably, among patients assessed with both PET/CT and I-CT, 2 individuals in the DLBCL group exhibited negative I-CT results despite positive I-PET/CT findings. Conversely, 3 HL patients showed positive I-CT findings despite negative I-PET/CT. Conclusion: PET/CT provided a substantial advantage in evaluating therapeutic response over conventional CT, reducing the risk of overtreatment in early-stage disease and undertreatment in more advanced stages. Interim PET/CT negativity was found to be a strong indicator of favorable progression-free survival outcomes, potentially guiding clinicians toward more individualized and less intensive treatment strategies. Nevertheless, confirmation of these findings through prospective randomized trials remains essential.

Keywords

Ethical Statement

It was approved by the Non-Interventional Ethics Committee of Dokuz Eylul University Faculty of Medicine with the decision number 2018/11-19 dated 03.05.2018.

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Details

Primary Language

English

Subjects

Clinical Oncology

Journal Section

Research Article

Authors

Esra Erpek ^*
0000-0003-3540-4905
Türkiye

Ayşegül Aksu
0000-0002-6239-0660
Türkiye

Hakan Abdullah Özgül
0000-0001-6123-0668
Türkiye

Ahmet Şeyhanlı
0000-0001-6082-2995
Türkiye

Özhan Özdoğan
0000-0002-3357-4778
Türkiye

Mustafa Seçil
0000-0001-7350-2202
Türkiye

Hayri Özsan
0000-0002-0930-6300
Türkiye

Publication Date

April 16, 2026

Submission Date

June 24, 2025

Acceptance Date

December 8, 2025

Published in Issue

Year 2026 Volume: 17 Number: 57

DOI

https://doi.org/10.17944/interdiscip.1726678

IZ

https://izlik.org/JA73CP97ZB

Cite

RIS / Bibtex

APA

Erpek, E., Aksu, A., Özgül, H. A., Şeyhanlı, A., Özdoğan, Ö., Seçil, M., & Özsan, H. (2026). The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience. Interdisciplinary Medical Journal, 17(57), 1-9. https://doi.org/10.17944/interdiscip.1726678

AMA

1.Erpek E, Aksu A, Özgül HA, et al. The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience. Interdiscip Med J. 2026;17(57):1-9. doi:10.17944/interdiscip.1726678

Chicago

Erpek, Esra, Ayşegül Aksu, Hakan Abdullah Özgül, et al. 2026. “The Correlation Between Interim Imaging Results and Disease Prognosis of Patients With Hodgkin and Diffuse Large B Cell Lymphoma: Single Center Experience”. Interdisciplinary Medical Journal 17 (57): 1-9. https://doi.org/10.17944/interdiscip.1726678.

EndNote

Erpek E, Aksu A, Özgül HA, Şeyhanlı A, Özdoğan Ö, Seçil M, Özsan H (April 1, 2026) The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience. Interdisciplinary Medical Journal 17 57 1–9.

IEEE

[1]E. Erpek et al., “The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience”, Interdiscip Med J, vol. 17, no. 57, pp. 1–9, Apr. 2026, doi: 10.17944/interdiscip.1726678.

ISNAD

Erpek, Esra - Aksu, Ayşegül - Özgül, Hakan Abdullah - Şeyhanlı, Ahmet - Özdoğan, Özhan - Seçil, Mustafa - Özsan, Hayri. “The Correlation Between Interim Imaging Results and Disease Prognosis of Patients With Hodgkin and Diffuse Large B Cell Lymphoma: Single Center Experience”. Interdisciplinary Medical Journal 17/57 (April 1, 2026): 1-9. https://doi.org/10.17944/interdiscip.1726678.

JAMA

1.Erpek E, Aksu A, Özgül HA, Şeyhanlı A, Özdoğan Ö, Seçil M, Özsan H. The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience. Interdiscip Med J. 2026;17:1–9.

MLA

Erpek, Esra, et al. “The Correlation Between Interim Imaging Results and Disease Prognosis of Patients With Hodgkin and Diffuse Large B Cell Lymphoma: Single Center Experience”. Interdisciplinary Medical Journal, vol. 17, no. 57, Apr. 2026, pp. 1-9, doi:10.17944/interdiscip.1726678.

Vancouver

1.Esra Erpek, Ayşegül Aksu, Hakan Abdullah Özgül, Ahmet Şeyhanlı, Özhan Özdoğan, Mustafa Seçil, Hayri Özsan. The correlation between interim imaging results and disease prognosis of patients with Hodgkin and diffuse large B cell lymphoma: single center experience. Interdiscip Med J. 2026 Apr. 1;17(57):1-9. doi:10.17944/interdiscip.1726678