Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats

Selim Demirtaş; Gül Şahika Gökdemir; Uğur Şeker

doi:10.17944/interdiscip.1739640

Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats

Abstract

Objective: The effects of diabetes on cardiomyopathy have been well documented in the literature. However, the effects of gilaburu fruit, which possesses antioxidant and anti-inflammatory properties, on diabetic cardiomyopathy (DCM) have not been adequately investigated. This study aimed to investigate the effects of gilaburu extract on DCM in diabetic rats. Method: Twenty-one male Wistar rats were divided into three groups. Diabetes was induced in the diabetic group with a single intraperitoneal (i.p.) injection of streptozotocin (STZ) at a dose of 50 mg/kg. The treatment group received gilaburu extract (200 mg/kg, i.p.) dissolved in phosphate buffer saline (PBS) for 37 days, starting one week before diabetes induction. Serum CK-MB and CRP levels, cardiac tissue MDA, SOD, and IL-1ß levels, as well as histopathological changes such as hypertrophy, vacuolization, and fiber disarray, were evaluated. Results: Serum CK-MB and CRP levels were significantly higher in the diabetic group compared to the control group. The diabetic group also exhibited marked myocardial hypertrophy, vacuolization, and fiber disarray, along with increased MDA and IL-1ß levels and decreased SODactivity. In the treatment group, CK-MB and CRP levels were significantly reduced, histopathological alterations were markedly attenuated, and MDA, IL-1ß, and SOD levels improved to values close to those of the control group. Conclusion: Gilaburu extract exhibits both biochemical and morphological protective effects against diabetic cardiomyopathy. These findings suggest that gilaburu may be a promising therapeutic agent for the management of diabetic cardiomyopathy.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmaceutical Chemistry, Pharmacology and Pharmaceutical Sciences (Other), Cardiology

Journal Section

Research Article

Authors

Selim Demirtaş ^*
0000-0001-7249-3092
Türkiye

Gül Şahika Gökdemir
0000-0002-8691-1504
Türkiye

Uğur Şeker
0000-0002-1693-6378
Türkiye

Publication Date

December 16, 2025

Submission Date

July 10, 2025

Acceptance Date

November 6, 2025

Published in Issue

Year 2025 Volume: 16 Number: 56

DOI

https://doi.org/10.17944/interdiscip.1739640

IZ

https://izlik.org/JA67RF36TU

Cite

RIS / Bibtex

APA

Demirtaş, S., Gökdemir, G. Ş., & Şeker, U. (2025). Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats. Interdisciplinary Medical Journal, 16(56), 205-212. https://doi.org/10.17944/interdiscip.1739640

AMA

1.Demirtaş S, Gökdemir GŞ, Şeker U. Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats. Interdiscip Med J. 2025;16(56):205-212. doi:10.17944/interdiscip.1739640

Chicago

Demirtaş, Selim, Gül Şahika Gökdemir, and Uğur Şeker. 2025. “Effects of Gilaburu Fruit Extract on Cardiomyopathy in Diabetic Rats”. Interdisciplinary Medical Journal 16 (56): 205-12. https://doi.org/10.17944/interdiscip.1739640.

EndNote

Demirtaş S, Gökdemir GŞ, Şeker U (December 1, 2025) Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats. Interdisciplinary Medical Journal 16 56 205–212.

IEEE

[1]S. Demirtaş, G. Ş. Gökdemir, and U. Şeker, “Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats”, Interdiscip Med J, vol. 16, no. 56, pp. 205–212, Dec. 2025, doi: 10.17944/interdiscip.1739640.

ISNAD

Demirtaş, Selim - Gökdemir, Gül Şahika - Şeker, Uğur. “Effects of Gilaburu Fruit Extract on Cardiomyopathy in Diabetic Rats”. Interdisciplinary Medical Journal 16/56 (December 1, 2025): 205-212. https://doi.org/10.17944/interdiscip.1739640.

JAMA

1.Demirtaş S, Gökdemir GŞ, Şeker U. Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats. Interdiscip Med J. 2025;16:205–212.

MLA

Demirtaş, Selim, et al. “Effects of Gilaburu Fruit Extract on Cardiomyopathy in Diabetic Rats”. Interdisciplinary Medical Journal, vol. 16, no. 56, Dec. 2025, pp. 205-12, doi:10.17944/interdiscip.1739640.

Vancouver

1.Selim Demirtaş, Gül Şahika Gökdemir, Uğur Şeker. Effects of gilaburu fruit extract on cardiomyopathy in diabetic rats. Interdiscip Med J. 2025 Dec. 1;16(56):205-12. doi:10.17944/interdiscip.1739640