The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder

Reyhan Koroglu; Muammer Urhan

doi:10.17944/interdiscip.1613184

The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder

Abstract

Objective: This study aimed to compare the visualization methods used in the follow-up of children diagnosed with neurogenic bladder and to determine which imaging method best predicts renal scarring. Method: A total of 33 children diagnosed with neurogenic bladder and 64 renal units were retrospectively evaluated. Renal ultrasound (USG), voiding cystourethrogram (VCUG), renal scintigraphy, and urine culture results obtained within 15 days were analyzed. Renal scars detected on the Technetium-99m dimercaptosuccinic acid (Tc-99m-DMSA) scan were accepted as the gold standard. The chi-square test was used to compare the results of VCUG, ultrasound, and Technetium-99m dietilentriaminepentaacetic acid (Tc-99m DTPA). Receiver Operating Characteristic Curve (ROC) analysis was performed to assess the predictive power of hydronephrosis (detected on USG) and vesicoureteral reflux (VUR) (detected on VCUG) in predicting renal scars. Results: The presence of renal scars on the Tc-99m DMSA scan was found to be 5 times higher in cases with VUR compared to those without (P=0.01, cutoff=2.00; sensitivity=0.50, specificity=0.89, positive predictive value (PPV)=0.58, negative predictive value (NPV)=0.85, area under the receiver operating characteristic curve (AUC)=0.691). The presence of renal scars was 9.3 times higher in patients with hydronephrosis detected by USG compared to those without (P=0.006, cutoff=2.0; sensitivity=0.85, specificity=0.63, PPV=0.41, NPV=0.93, AUC=0.764). Conclusion: Renal scars must be investigated in children with neurogenic bladder in the presence of both VUR and hydronephrosis, which are the two most important complications. It should also be considered that renal parenchymal damage may occur even in cases with low-grade VUR or hydronephrosis.

Keywords

References

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Details

Primary Language

English

Subjects

Paediatrics (Other), Internal Diseases

Journal Section

Research Article

Authors

Reyhan Koroglu ^*
0000-0002-3344-915X
Türkiye

Muammer Urhan This is me
0000-0002-6464-9648
Türkiye

Publication Date

December 16, 2025

Submission Date

January 4, 2025

Acceptance Date

May 24, 2025

Published in Issue

Year 2025 Volume: 16 Number: 56

DOI

https://doi.org/10.17944/interdiscip.1613184

IZ

https://izlik.org/JA83YH79YT

Cite

RIS / Bibtex

APA

Koroglu, R., & Urhan, M. (2025). The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder. Interdisciplinary Medical Journal, 16(56), 130-136. https://doi.org/10.17944/interdiscip.1613184

AMA

1.Koroglu R, Urhan M. The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder. Interdiscip Med J. 2025;16(56):130-136. doi:10.17944/interdiscip.1613184

Chicago

Koroglu, Reyhan, and Muammer Urhan. 2025. “The Role of Hydronephrosis and Vesicoureteral Reflux in Predicting Renal Scarring in Pediatric Neurogenic Bladder”. Interdisciplinary Medical Journal 16 (56): 130-36. https://doi.org/10.17944/interdiscip.1613184.

EndNote

Koroglu R, Urhan M (December 1, 2025) The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder. Interdisciplinary Medical Journal 16 56 130–136.

IEEE

[1]R. Koroglu and M. Urhan, “The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder”, Interdiscip Med J, vol. 16, no. 56, pp. 130–136, Dec. 2025, doi: 10.17944/interdiscip.1613184.

ISNAD

Koroglu, Reyhan - Urhan, Muammer. “The Role of Hydronephrosis and Vesicoureteral Reflux in Predicting Renal Scarring in Pediatric Neurogenic Bladder”. Interdisciplinary Medical Journal 16/56 (December 1, 2025): 130-136. https://doi.org/10.17944/interdiscip.1613184.

JAMA

1.Koroglu R, Urhan M. The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder. Interdiscip Med J. 2025;16:130–136.

MLA

Koroglu, Reyhan, and Muammer Urhan. “The Role of Hydronephrosis and Vesicoureteral Reflux in Predicting Renal Scarring in Pediatric Neurogenic Bladder”. Interdisciplinary Medical Journal, vol. 16, no. 56, Dec. 2025, pp. 130-6, doi:10.17944/interdiscip.1613184.

Vancouver

1.Reyhan Koroglu, Muammer Urhan. The role of hydronephrosis and vesicoureteral reflux in predicting renal scarring in pediatric neurogenic bladder. Interdiscip Med J. 2025 Dec. 1;16(56):130-6. doi:10.17944/interdiscip.1613184