Bromelain protects kidneys against cyclophosphamide nephrotoxicity

Alper Yalçın

doi:10.17944/interdiscip.1944386

Bromelain protects kidneys against cyclophosphamide nephrotoxicity

Abstract

Objective: Cyclophosphamide (CP) is an anticancer drug; however, it has toxic adverse effects on kidney. Bromelain (BRM) is a proteolytic enzyme found in pineapple plants, having many activities in several areas of therapeutic treatments. In this experimental study, BRM was evaluated for its ability to suppress apoptosis and inflammation on CP-induced nephrotoxicity. Method: Twenty-four female albino rats (Wistar strain) were distributed into four groups (n=6): control, BRM, CP, and CP+BRM. Kidney tissues of rats were used to evaluate the apoptotic and inflammatory changes. Results: In the CP group, severe histological damage was evident; tumor necrosis factor (TNF-α), interleukin 6 (IL-6), Bcl-2-associated x protein (Bax) immunoreactivities were increased, but no statistically significant change was observed in the immunoactivity of B-cell lymphoma-2 (Bcl-2). In the CP + BRM group, BRM restored renal histopathology, and inhibited the overexpression of CP-induced apoptotic and inflammatory markers. Moreover, a statistically significant increase was observed for Bcl-2 expression in the treatment group. Conclusions: The current study indicates a significant role of apoptosis and inflammation in CP-induced kidney injury and points to the therapeutic potential of BRM against CP-induced nephrotoxicity.

Keywords

Ethical Statement

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the animal experiments local ethical committee of Harran University (Approvel number; 2026-001/01-9).

Thanks

The author would like to thank Prof. Fatih Uckardes (Department of Biostatistics and Medical Informatics, Faculty of Medicine, Adiyaman University, Türkiye) for his assistance with the statistical analysis, as well as Dr. Sibel Türedi (Department of Histology and Embryology, Faculty of Medicine, Harran University,Türkiye) for her assistance with the experimental and histopathological laboratory support.

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Details

Primary Language

English

Subjects

Medical Pharmacology

Journal Section

Research Article

Authors

Alper Yalçın ^*
0000-0002-8975-1008
Türkiye

Publication Date

August 23, 2026

Submission Date

May 5, 2026

Acceptance Date

July 7, 2026

Published in Issue

Year 2026 Volume: 17 Number: 58

DOI

https://doi.org/10.17944/interdiscip.1944386

IZ

https://izlik.org/JA54ZE78BC

Cite

RIS / Bibtex

APA

Yalçın, A. (2026). Bromelain protects kidneys against cyclophosphamide nephrotoxicity. Interdisciplinary Medical Journal, 17(58), 178-184. https://doi.org/10.17944/interdiscip.1944386

AMA

1.Yalçın A. Bromelain protects kidneys against cyclophosphamide nephrotoxicity. Interdiscip Med J. 2026;17(58):178-184. doi:10.17944/interdiscip.1944386

Chicago

Yalçın, Alper. 2026. “Bromelain Protects Kidneys Against Cyclophosphamide Nephrotoxicity”. Interdisciplinary Medical Journal 17 (58): 178-84. https://doi.org/10.17944/interdiscip.1944386.

EndNote

Yalçın A (August 1, 2026) Bromelain protects kidneys against cyclophosphamide nephrotoxicity. Interdisciplinary Medical Journal 17 58 178–184.

IEEE

[1]A. Yalçın, “Bromelain protects kidneys against cyclophosphamide nephrotoxicity”, Interdiscip Med J, vol. 17, no. 58, pp. 178–184, Aug. 2026, doi: 10.17944/interdiscip.1944386.

ISNAD

Yalçın, Alper. “Bromelain Protects Kidneys Against Cyclophosphamide Nephrotoxicity”. Interdisciplinary Medical Journal 17/58 (August 1, 2026): 178-184. https://doi.org/10.17944/interdiscip.1944386.

JAMA

1.Yalçın A. Bromelain protects kidneys against cyclophosphamide nephrotoxicity. Interdiscip Med J. 2026;17:178–184.

MLA

Yalçın, Alper. “Bromelain Protects Kidneys Against Cyclophosphamide Nephrotoxicity”. Interdisciplinary Medical Journal, vol. 17, no. 58, Aug. 2026, pp. 178-84, doi:10.17944/interdiscip.1944386.

Vancouver

1.Alper Yalçın. Bromelain protects kidneys against cyclophosphamide nephrotoxicity. Interdiscip Med J. 2026 Aug. 1;17(58):178-84. doi:10.17944/interdiscip.1944386