Research Article
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The relationship of preterm birth with fetal fibronectin level in cervicovaginal fluid and cervical lenght in ultrasonography

Year 2023, Volume: 14 Issue: 50, 158 - 163, 30.12.2023
https://doi.org/10.17944/interdiscip.1329535

Abstract

Objective: In this study, the compatibility between fetal fibronectin determination and the use of cervical length measured by transvaginal ultrasonography of patients who were at risk of preterm birth in the examination performed at 24-34 weeks of gestation, and patients with an increased risk of preterm birth according to the result were defined.

Method: 40 patients who applied to Mustafa Kemal University Training and Research Hospital Gynecology and Obstetrics outpatient clinic between May 2021 and May 2022 were included in the study. Fibronectin results were evaluated using the liquid ELISA method taken from the vaginal secretion by a swap. Cervical lengths were evaluated as 25 mm and below, between 25-30 mm and 30 mm and above in statistical data.

Results: For fFN-positive patients, the preterm delivery rate of patients with a cervical length of 25 mm and less was determined as 100%, while the rate of preterm birth was determined as 77.8% for patients with a cervical length between 25 mm and 30 mm. In addition, the preterm labor rate of fFN-positive patients with a cervical length of 30 mm and above was determined as 78.57%.

Conclusion: All patients with a cervical length of 25 mm or less have a positive fFN test, and a strong correlation can be established between these two values. Accordingly, fFN positivity was found to have a higher sensitivity in determining the probability of preterm delivery compared to the cervical length ratio.

Project Number

21.TU.012

References

  • ong C.Y. Defining “term” pregnancy: Recommendations from the defining “term” pregnancy workgroup. Obstetrical and Gynecological Survey 2013;68(9):611-2. https://doi.org/10.1097/01.ogx.0000435519.66840.48
  • Simhan HN, Caritis SN. Prevention of preterm delivery. N Engl J Med 2007;357(5):477-87 https://doi.org/10.1056/NEJMra050435
  • Slattery MM, Morrison JJ. Preterm delivery. Lancet 2015;360(9344):1489-97. https://doi.org/10.1016/S0140-6736(02)11476-0
  • Iams JD, Berghella V. Care for Women with Prior Preterm Birth. In: Preterm Birth: Prevention and Management. Am J Obstet Gynecol 2010;203(2):89-100. https://doi.org/10.1016/j.ajog.2010.02.004
  • Iams JD, Goldenberg RL, Mercer BM, et al. The Preterm Prediction Study: Recurrence risk of spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 1998;178(5):1035-40. https://doi.org/10.1016/S0002-9378(98)70544-7
  • Chuileannain FN, Bell R, Brennecke S. Cervicovaginal fetal fibronectin testing in threatened preterm labor - Translating research findings into clinical practice. Aust NZ Obstet Gynaecol 1998;38(4):399-402. https://doi.org/10.1111/j.1479-828X.1998.tb03096.x
  • Tekesin I, Marek S, Hellmeyer L, Reitz D, Schmidt S. Assessment of Rapid Fetal Fibronectin in Predicting Preterm Delivery. Obstet Gynecol 2005;105(2):280-4. https://doi.org/10.1097/01.AOG.0000150557.00298.47
  • Peaceman AM, Andrews WW, Thorp JM, Cliver SP, Lukes A, Iams JD, et al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am J Obstet Gynecol 1997;177:13-8. https://doi.org/10.1016/S0002-9378(97)70431-9
  • Sakai M, Sasaki Y, Yamagishi N, Tanebe K, Yoneda S, Saito S. The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes. American College of Obstetricians and Gynecologists 2003;101:123-8. https://doi.org/10.1016/S0029-7844(02)02463-8
  • Rozenberg P, Goffinet F, Malagrida L, Giudicelli Y, Perdu M, Houssin I, et al. Evaluating the risk of preterm delivery: A comparison of fetal fibronectin and transvaginal ultrasonographic measurement of cervical length. Am J Obstet Gynecol 1997;176(1):196-9. https://doi.org/10.1016/S0002-9378(97)80035-X
  • Rottenstreich A, Levin G, Kleinstern G. History-indicated cervical cerclage in management of twin pregnancy. Ultrasound Obstet Gynecol 2019;54:517-23. https://doi.org/10.1002/uog.20192
  • Sen C. Preterm labor and preterm birth. J Perinat Med 2017;27;45(8):911-13. https://doi.org/10.1515/jpm-2017-0298
Year 2023, Volume: 14 Issue: 50, 158 - 163, 30.12.2023
https://doi.org/10.17944/interdiscip.1329535

Abstract

Supporting Institution

mustafa kemal üniversitesi BAP birimi

Project Number

21.TU.012

Thanks

hatay mustafa kemal üniversitesi BAP birimine teşekkürler.

References

  • ong C.Y. Defining “term” pregnancy: Recommendations from the defining “term” pregnancy workgroup. Obstetrical and Gynecological Survey 2013;68(9):611-2. https://doi.org/10.1097/01.ogx.0000435519.66840.48
  • Simhan HN, Caritis SN. Prevention of preterm delivery. N Engl J Med 2007;357(5):477-87 https://doi.org/10.1056/NEJMra050435
  • Slattery MM, Morrison JJ. Preterm delivery. Lancet 2015;360(9344):1489-97. https://doi.org/10.1016/S0140-6736(02)11476-0
  • Iams JD, Berghella V. Care for Women with Prior Preterm Birth. In: Preterm Birth: Prevention and Management. Am J Obstet Gynecol 2010;203(2):89-100. https://doi.org/10.1016/j.ajog.2010.02.004
  • Iams JD, Goldenberg RL, Mercer BM, et al. The Preterm Prediction Study: Recurrence risk of spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol 1998;178(5):1035-40. https://doi.org/10.1016/S0002-9378(98)70544-7
  • Chuileannain FN, Bell R, Brennecke S. Cervicovaginal fetal fibronectin testing in threatened preterm labor - Translating research findings into clinical practice. Aust NZ Obstet Gynaecol 1998;38(4):399-402. https://doi.org/10.1111/j.1479-828X.1998.tb03096.x
  • Tekesin I, Marek S, Hellmeyer L, Reitz D, Schmidt S. Assessment of Rapid Fetal Fibronectin in Predicting Preterm Delivery. Obstet Gynecol 2005;105(2):280-4. https://doi.org/10.1097/01.AOG.0000150557.00298.47
  • Peaceman AM, Andrews WW, Thorp JM, Cliver SP, Lukes A, Iams JD, et al. Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter trial. Am J Obstet Gynecol 1997;177:13-8. https://doi.org/10.1016/S0002-9378(97)70431-9
  • Sakai M, Sasaki Y, Yamagishi N, Tanebe K, Yoneda S, Saito S. The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes. American College of Obstetricians and Gynecologists 2003;101:123-8. https://doi.org/10.1016/S0029-7844(02)02463-8
  • Rozenberg P, Goffinet F, Malagrida L, Giudicelli Y, Perdu M, Houssin I, et al. Evaluating the risk of preterm delivery: A comparison of fetal fibronectin and transvaginal ultrasonographic measurement of cervical length. Am J Obstet Gynecol 1997;176(1):196-9. https://doi.org/10.1016/S0002-9378(97)80035-X
  • Rottenstreich A, Levin G, Kleinstern G. History-indicated cervical cerclage in management of twin pregnancy. Ultrasound Obstet Gynecol 2019;54:517-23. https://doi.org/10.1002/uog.20192
  • Sen C. Preterm labor and preterm birth. J Perinat Med 2017;27;45(8):911-13. https://doi.org/10.1515/jpm-2017-0298
There are 12 citations in total.

Details

Primary Language English
Subjects Obstetrics and Gynaecology
Journal Section Research Articles
Authors

Anıl Arpacı 0009-0001-5144-2146

Oya Soylu Karapınar 0000-0001-9990-7654

Project Number 21.TU.012
Publication Date December 30, 2023
Submission Date July 19, 2023
Published in Issue Year 2023 Volume: 14 Issue: 50

Cite

Vancouver Arpacı A, Soylu Karapınar O. The relationship of preterm birth with fetal fibronectin level in cervicovaginal fluid and cervical lenght in ultrasonography. Interdiscip Med J. 2023;14(50):158-63.