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Unusual finding on bone scintigraphy: Cerebral 99m-tc mdp involvement

Year 2024, Volume: 15 Issue: 52, 96 - 98, 02.09.2024
https://doi.org/10.17944/interdiscip.1409955

Abstract

99mTc-MDP (99mTc-methylene diphosphonate) uptake in the brain parenchyma was observed in the scintigraphic imaging of a 56 years old male patient with renal cell carcinoma (RCC), who was referred to our clinic for metastasis screening due to widespread bone pain. Uptake of 99mTc-MDP in the brain parenchyma in bone scintigraphy is a rare finding. This case is presented to reveal the causes of cerebral 99mTc-MDP involvement.

References

  • Gnanasegaran G, Cook G, Adamson K, Fogelman I. Patterns. Variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39(6):380-95. https://doi.org/10.1053/j.semnuclmed.2009.07.003
  • O'Connor MK, Brown ML, Hung JC, Hayostek RJ. The art of bone scintigraphy--technical aspects. J Nucl Med. 1991;32(12):2332-41.
  • Horger M, Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin Nucl Med. 2006;36(4):286-94. https://doi.org/10.1053/j.semnuclmed.2006.05.001
  • Mohd Rohani MF, Zanial AZ, Suppiah S, et al. Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work. Nucl Med Commun. 2021;42(1):9-20. https://doi.org/10.1097/MNM.0000000000001306
  • Van den Wyngaert T, Strobel K, Kampen WU, et al; EANM Bone & Joint Committee and the Oncology Committee. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43(9):1723-38. https://doi.org/10.1007/s00259-016-3415-4
  • O'Sullivan JM, Cook GJ. A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med. 2002;46(2):152-9.
  • Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003;23(2):341-58. https://doi.org/10.1148/rg.232025103
  • Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd ed. AJNR Am J Neuroradiol. 2006;27(2):464–5.
  • Crawshaw JW, Allan R. Middle cerebral artery infarct demonstrated on bone scintigraphy. Eur J Nucl Med Mol Imaging. 2007;34(2):306. https://doi.org/10.1007/s00259-006-0181-8
  • Zuckier LS, Martineau P. Altered biodistribution of radiopharmaceuticals used in bone scintigraphy. Semin Nucl Med. 2015;45(1):81-96. https://doi.org/10.1053/j.semnuclmed.2014.07.007
  • Peller PJ, Ho VB, Kransdorf MJ. Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 1993;13(4):715-34. https://doi.org/10.1148/radiographics.13.4.8356264
Year 2024, Volume: 15 Issue: 52, 96 - 98, 02.09.2024
https://doi.org/10.17944/interdiscip.1409955

Abstract

References

  • Gnanasegaran G, Cook G, Adamson K, Fogelman I. Patterns. Variants, artifacts, and pitfalls in conventional radionuclide bone imaging and SPECT/CT. Semin Nucl Med. 2009;39(6):380-95. https://doi.org/10.1053/j.semnuclmed.2009.07.003
  • O'Connor MK, Brown ML, Hung JC, Hayostek RJ. The art of bone scintigraphy--technical aspects. J Nucl Med. 1991;32(12):2332-41.
  • Horger M, Bares R. The role of single-photon emission computed tomography/computed tomography in benign and malignant bone disease. Semin Nucl Med. 2006;36(4):286-94. https://doi.org/10.1053/j.semnuclmed.2006.05.001
  • Mohd Rohani MF, Zanial AZ, Suppiah S, et al. Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work. Nucl Med Commun. 2021;42(1):9-20. https://doi.org/10.1097/MNM.0000000000001306
  • Van den Wyngaert T, Strobel K, Kampen WU, et al; EANM Bone & Joint Committee and the Oncology Committee. The EANM practice guidelines for bone scintigraphy. Eur J Nucl Med Mol Imaging. 2016;43(9):1723-38. https://doi.org/10.1007/s00259-016-3415-4
  • O'Sullivan JM, Cook GJ. A review of the efficacy of bone scanning in prostate and breast cancer. Q J Nucl Med. 2002;46(2):152-9.
  • Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003;23(2):341-58. https://doi.org/10.1148/rg.232025103
  • Nuclear Medicine in Clinical Diagnosis and Treatment, 3rd ed. AJNR Am J Neuroradiol. 2006;27(2):464–5.
  • Crawshaw JW, Allan R. Middle cerebral artery infarct demonstrated on bone scintigraphy. Eur J Nucl Med Mol Imaging. 2007;34(2):306. https://doi.org/10.1007/s00259-006-0181-8
  • Zuckier LS, Martineau P. Altered biodistribution of radiopharmaceuticals used in bone scintigraphy. Semin Nucl Med. 2015;45(1):81-96. https://doi.org/10.1053/j.semnuclmed.2014.07.007
  • Peller PJ, Ho VB, Kransdorf MJ. Extraosseous Tc-99m MDP uptake: a pathophysiologic approach. Radiographics. 1993;13(4):715-34. https://doi.org/10.1148/radiographics.13.4.8356264
There are 11 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Case Reports
Authors

Edanur Ekinci 0000-0003-3850-5816

Ebuzer Kalender 0000-0001-8472-3174

Yusuf Burak Çayırlı 0000-0001-7563-3484

Publication Date September 2, 2024
Submission Date December 25, 2023
Acceptance Date May 4, 2024
Published in Issue Year 2024 Volume: 15 Issue: 52

Cite

Vancouver Ekinci E, Kalender E, Çayırlı YB. Unusual finding on bone scintigraphy: Cerebral 99m-tc mdp involvement. Interdiscip Med J. 2024;15(52):96-8.