Effects of atropine used as eye drops on tears, pupil diameter and intraocular pressure in rabbits

Year 2024, Volume: 15 Issue: 53, 106 - 112, 05.12.2024

Mehmet Çömez , Cafer Tayer İşler

Abstract

Objective: It was aimed to determine the effects of using atropine as eye drops on tear amount (Schirmer tear test, STT), pupil diameter (PD), and intraocular pressure (IOP).
Method: STT, PD and IOP measurements were made before instillation of atropine and 30 minutes after instillation of single dose atropine for seven days in the six (6) male New Zealand Rabbits. Measurements were evaluated in Wilcoxon Signed Ranks Test.
Results: The STT, PD and IOP measurement values of both left and right eyes of the atropine group were statistically significantly different compared to those who did not receive atropine (P<0.05).
Conclusion: Atropine increase the PD values in the eye, decrease the STT values and increase the IOP values if it use in long-term.

Keywords

Atropine, Schirmer tear test, intraocular pressure, pupil diameter

References

• Alagöz G, Serin D, Tırak E, Kükner Ş. Pupiller yorgunluk. MN Oftalmoloji. 2006;13(3):208-10.
• Taylor HR, West S, Muñoz B, Rosenthal FS, Bressler SB, Bressler NM. The long-term effects of visible light on the eye. Arch Ophthalmol. 1992;110(1):99-104. https://doi.org/10.1001/archopht.1992.01080130101035
• Hofmeister EM, Kaupp SE, Schallhorn SC. Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients. J Cataract Refract Surg. 2005;31(4):694-700. https://doi.org/10.1016/j.jcrs.2004.10.068
• Akpolat Ç, Kurt MM, Evliyaoğlu F,Elcioğlu MN. Pupil Diameter Study: Factors Effecting Pupil Size In Diabetic Patients. Ret-Vit. 2019;28(2):117-21.
• Koç Y, Alkan F, Tepeli C. Schirmer tear test in different rabbit breeds. Hayvancılık Araştırma Dergisi. 2005;15(2):1-5.
• Gelatt KN. Essentials of veterinary ophthalmology: John Wiley & Sons; 2013. https://doi.org/10.1002/9781118910337
• Mughannam AJ, Buyukmihci NC, Kass PH. Effect of topical atropine on intraocular pressure and pupil diameter in the normal horse eye. Vet Ophthalmol. 1999;2(4):213-5. https://doi.org/10.1046/j.1463-5224.1999.00081.x
• Wu T-EJ, Yang C-C, Chen H-S. Does atropine use increase intraocular pressure in myopic children? OOptom Vis Sci. 2012;89(2):E161-E7. https://doi.org/10.1097/OPX.0b013e31823ac4c1
• Liang X, Wei S, Li S-M, An W, Du J, Sun Y, et al. Effect of Atropine 0.01% Eye Drops on the Difference in Refraction and Axial Length between Right and Left Eyes. Ophthalmic Res. 2023;66(1):484-93. https://doi.org/10.1159/000528878
• Lee C-Y, Sun C-C, Lin Y-F, Lin K-K. Effects of topical atropine on intraocular pressure and myopia progression: a prospective comparative study. BMC Ophthalmol. 2016;16(1):1-7. https://doi.org/10.1186/s12886-016-0297-y
• Wei S, Li S-M, An W, Du J, Liang X, Sun Y, et al. Safety and efficacy of low-dose atropine eyedrops for the treatment of myopia progression in Chinese children: a randomized clinical trial. JAMA Ophthalmol. 2020;138(11):1178-84. https://doi.org/10.1001/jamaophthalmol.2020.3820
• Bukhari J, Wei S-F, Li S-M, An W-Z, Du J-L, Liang X-T, et al. Effect of 0.01% atropine eyedrops on intraocular pressure in schoolchildren: a randomized clinical trial. Int J Ophthalmol. 2022;15(9):1431. https://doi.org/10.18240/ijo.2022.09.04
• Zhou Y, Huang XB, Cai Q, Li JJ, Xiong YJ, Gong YX, et al. Comparative study of the effects of 1% atropine on the anterior segment. J Ophthalmol. 2020;2020. https://doi.org/10.1155/2020/5125243
• Davis J, Stewart T, Brazik E, Gilger B. The effect of topical administration of atropine sulfate on the normal equine pupil: influence of age, breed and gender. Vet Ophthalmol. 2003;6(4):329-32. https://doi.org/10.1111/j.1463-5224.2003.00315.x
• Ward D. Clinical ophthalmic pharmacology and therapeutics. Vet Ophthalmol. 1999;315.
• Ho M-C, Hsieh Y-T, Shen EP, Hsu W-C, Cheng H-C. Short-term refractive and ocular parameter changes after topical atropine. Taiwan J Ophthalmol. 2020;10(2):111. https://doi.org/10.4103/tjo.tjo_110_18
• Chua W-H, Balakrishnan V, Chan Y-H, Tong L, Ling Y, Quah B-L, et al. Atropine for the treatment of childhood myopia. Ophthalmology. 2006;113(12):2285-91. https://doi.org/10.1016/j.ophtha.2006.05.062
• Hollingsworth SR, Canton DD, Buyukmihci NC, Farver T. Effect of topically administered atropine on tear production in dogs. J Am Vet Med Assoc. 1992;200(10):1481-4. https://doi.org/10.2460/javma.1992.200.10.1481