FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES
Abstract
The prevalence of autoimmune thyroid disease (AITD) has progressively increased. Circulating autoantibodies associated with AITD may affect the result of laboratory analyses and cause incorrect conclusions in the assessment of thyroid hormone status. In this report, we present a patient with Hashimoto’s thyroiditis with high thyrotrophin and free thyroxine (T4) and triiodothyronine (T3) levels due to the presence of auto-antibodies to iodothyronines. Free T4 and free T3 levels measured by direct immunometric assays method were high, while those estimated by measurement of the serum T4-binding capacity were low. L-thyroxine replacement therapy was started. In patients with discrepant laboratory results, interference from autoantibodies should be considered.
Key words: Thyroxine auto-antibody, hypothyroidism, false high free thyroxine, triiodothyronine levels,
Keywords
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
-
Authors
Caecilie Crawley Larsen
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Solomon Maximo Greenberg
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Alfonso Massimiliano Ferrara
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Samuel Refetoff
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Ferda Sevimli Burnık
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Publication Date
April 19, 2016
Submission Date
January 8, 2016
Acceptance Date
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Published in Issue
Year 2016 Volume: 79 Number: 1