FALSE ELEVATION OF FREE THYROXINE AND TRIIODOTHYRONINE DUE TO THE PRESENCE OF ANTIBODIES TO IODOTHYRONINES
Öz
The prevalence of autoimmune thyroid disease (AITD) has progressively increased. Circulating autoantibodies associated with AITD may affect the result of laboratory analyses and cause incorrect conclusions in the assessment of thyroid hormone status. In this report, we present a patient with Hashimoto’s thyroiditis with high thyrotrophin and free thyroxine (T4) and triiodothyronine (T3) levels due to the presence of auto-antibodies to iodothyronines. Free T4 and free T3 levels measured by direct immunometric assays method were high, while those estimated by measurement of the serum T4-binding capacity were low. L-thyroxine replacement therapy was started. In patients with discrepant laboratory results, interference from autoantibodies should be considered.
Key words: Thyroxine auto-antibody, hypothyroidism, false high free thyroxine, triiodothyronine levels,
Anahtar Kelimeler
Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
-
Yazarlar
Caecilie Crawley Larsen
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Solomon Maximo Greenberg
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Alfonso Massimiliano Ferrara
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Samuel Refetoff
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Ferda Sevimli Burnık
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Yayımlanma Tarihi
19 Nisan 2016
Gönderilme Tarihi
8 Ocak 2016
Kabul Tarihi
-
Yayımlandığı Sayı
Yıl 2016 Cilt: 79 Sayı: 1