Case Report
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PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW

Year 2017, Volume: 80 Issue: 2, 82 - 85, 30.06.2017
https://doi.org/10.18017/iuitfd.330078

Abstract

Pseudoangiomatous
stromal hyperplasia (PASH) is a benign proliferative lesion of the breast
stroma characterized by slit-like pseudovascular spaces lined by
endothelial-like spindle cells. It is frequently found as incidental
microscopic foci in the female breast and in gynecomastia of the male breast,
but it rarely presents as a clinical problem. We report a case of bilateral
extreme breast enlargement caused by PASH in an adolescent girl who was treated
with subcutaneous mastectomy and reconstruction with breast implants following
a recurrence after treatment with free nipple graft breast reduction.



Keywords: Pseudoangiomatous stromal hyperplasia; mammaplasty; breast implants. 

References

  • 1. Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol 1986;17(2):185-91.
  • 2. Leon ME, Leon MA, Ahuja J, Garcia FU. Nodular myofibroblastic stromal hyperplasia of the mammary gland as an accurate name for pseudoangiomatous stromal hyperplasia of the mammary gland. Breast J 2002;8(5):290-3.
  • 3. Badve S, Sloane JP. Pseudoangiomatous hyperplasia of male breast. Histopathology 1995;26(5):463-6.
  • 4. Haj M, Loberant N, Cohen I. Pseudoangiomatous hyperplasia of mammary stroma in a male breast presenting as a discrete nodule. Breast J 2005;11(6):472-3.
  • 5. Wieman SM, Landercasper J, Johnson JM, Ellis RL, Wester SM, Lambert PJ, Ross LA. Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg 2008;74(12): 1211-4.
  • 6. Drinka EK, Bargaje A, Ersahin CH, Patel P, Salhadar A, Sinacore J, Rajan P. Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases. Int J Surg Pathol 2011;20(1):54-8.
  • 7. Ozturk S, Yavuz E, Dursun M, Asoglu O, Ilhan R, Tuzlali S, Iplikci A. Pseudoangiomatous stromal hyperplasia of the breast (morphological and immunohistochemical analysis of 14 cases). Turk J Pathol 2005;21(3-4): 54-7.
  • 8. Guven E, Aydin H, Basaran K, Aydin U, Kuvat SV. Reduction mammaplasty using bipedicled dermoglandular flaps and free-nipple transplantation. Aesthetic Plast Surg 2010;34(6):738-44
  • 9. Dancey A, Khan M, Dawson J, Peart F. Gigantomastia--a classification and review of the literature. J Plast Reconstr Aesthet Surg 2008;61(5):493-502
  • 10. Schumacher O, Ashkar W, Dabernig J, Nenadic I, Ingianni G. Juvenile gigantomastia of extreme magnitude: a case report. Ann Plast Surg 2009;63(4):369-72.
  • 11. Baker SB, Burkey BA, Thornton P, LaRossa D. Juvenile gigantomastia: presentation of four cases and review of the literature. Ann Plast Surg 2001;46(5):517-25.
  • 12. Ibrahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer 1989;63(6):1154-60.
  • 13. Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, Bumpers HL. Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J 2012;18(3):242-7.
  • 14. Guray M, Sahin AA. Benign breast diseases: classification, diagnosis, and management. Oncologist 2006;11(5):435-49.
  • 15. Castro CY, Whitman GJ, Sahin AA. Pseudoangiomatous stromal hyperplasia of the breast. Am J Clin Oncol 2002;25(2):213-6.
  • 16. Pruthi S, Reynolds C, Johnson RE, Gisvold JJ. Tamoxifen in the management of pseudoangiomatous stromal hyperplasia. Breast J 2001;7(6):434-9.
  • 17. Powell CM, Cranor ML, Rosen PP. Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation. Am J Surg Pathol 1995;19(3):270-7.
  • 18. Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW. Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol 2010;17(12):3269-77.
  • 19. Ferreira M, Albarracin CT, Resetkova E. Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol 2008;21(2):201-7.

ADOLESAN KIZ ÇOCUĞUNDA PSÖDOANJİYOMATÖZ STROMAL HİPERPLAZİ: OLGU SUNUMU VE LİTERATÜR DERLEMESİ

Year 2017, Volume: 80 Issue: 2, 82 - 85, 30.06.2017
https://doi.org/10.18017/iuitfd.330078

Abstract

Psödoanjiyomatöz
stromal hiperplazi (PASH) meme bağ dokusunun benign proliferatif lezyonlarından
birisidir. Endotel benzeri iğsi hücrelerle döşeli yarık benzeri psödovasküler
alanlarla karakterizedir. Meme eksizyonu ve jinekomasti piyeslerinde sıklıkla
insidental olarak görülse de nadiren klinik bir sorun olarak karşımıza çıkmaktadır.
Bu olgu sunumunda PASH nedeniyle aşırı derecede bilateral meme büyümesi
ile kliniğimize başvuran adolesan bir kız çocuğunun klinik seyri ve tedavisi
bildirilmektedir. Bu hastaya, serbest meme grefti kullanılarak meme küçültme
ameliyatı yapıldıktan sonra gelişen nüks nedeniyle subkutan mastektomi yapılmış
ve meme implantı yerleştirilmiştir.



Anahtar
Kelimeler: 
Psödoanjiyomatöz
stromal hiperplazi; mamoplasti; meme İmplantları.

References

  • 1. Vuitch MF, Rosen PP, Erlandson RA. Pseudoangiomatous hyperplasia of mammary stroma. Hum Pathol 1986;17(2):185-91.
  • 2. Leon ME, Leon MA, Ahuja J, Garcia FU. Nodular myofibroblastic stromal hyperplasia of the mammary gland as an accurate name for pseudoangiomatous stromal hyperplasia of the mammary gland. Breast J 2002;8(5):290-3.
  • 3. Badve S, Sloane JP. Pseudoangiomatous hyperplasia of male breast. Histopathology 1995;26(5):463-6.
  • 4. Haj M, Loberant N, Cohen I. Pseudoangiomatous hyperplasia of mammary stroma in a male breast presenting as a discrete nodule. Breast J 2005;11(6):472-3.
  • 5. Wieman SM, Landercasper J, Johnson JM, Ellis RL, Wester SM, Lambert PJ, Ross LA. Tumoral pseudoangiomatous stromal hyperplasia of the breast. Am Surg 2008;74(12): 1211-4.
  • 6. Drinka EK, Bargaje A, Ersahin CH, Patel P, Salhadar A, Sinacore J, Rajan P. Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Clinicopathological Study of 79 Cases. Int J Surg Pathol 2011;20(1):54-8.
  • 7. Ozturk S, Yavuz E, Dursun M, Asoglu O, Ilhan R, Tuzlali S, Iplikci A. Pseudoangiomatous stromal hyperplasia of the breast (morphological and immunohistochemical analysis of 14 cases). Turk J Pathol 2005;21(3-4): 54-7.
  • 8. Guven E, Aydin H, Basaran K, Aydin U, Kuvat SV. Reduction mammaplasty using bipedicled dermoglandular flaps and free-nipple transplantation. Aesthetic Plast Surg 2010;34(6):738-44
  • 9. Dancey A, Khan M, Dawson J, Peart F. Gigantomastia--a classification and review of the literature. J Plast Reconstr Aesthet Surg 2008;61(5):493-502
  • 10. Schumacher O, Ashkar W, Dabernig J, Nenadic I, Ingianni G. Juvenile gigantomastia of extreme magnitude: a case report. Ann Plast Surg 2009;63(4):369-72.
  • 11. Baker SB, Burkey BA, Thornton P, LaRossa D. Juvenile gigantomastia: presentation of four cases and review of the literature. Ann Plast Surg 2001;46(5):517-25.
  • 12. Ibrahim RE, Sciotto CG, Weidner N. Pseudoangiomatous hyperplasia of mammary stroma. Some observations regarding its clinicopathologic spectrum. Cancer 1989;63(6):1154-60.
  • 13. Bowman E, Oprea G, Okoli J, Gundry K, Rizzo M, Gabram-Mendola S, Manne U, Smith G, Pambuccian S, Bumpers HL. Pseudoangiomatous stromal hyperplasia (PASH) of the breast: a series of 24 patients. Breast J 2012;18(3):242-7.
  • 14. Guray M, Sahin AA. Benign breast diseases: classification, diagnosis, and management. Oncologist 2006;11(5):435-49.
  • 15. Castro CY, Whitman GJ, Sahin AA. Pseudoangiomatous stromal hyperplasia of the breast. Am J Clin Oncol 2002;25(2):213-6.
  • 16. Pruthi S, Reynolds C, Johnson RE, Gisvold JJ. Tamoxifen in the management of pseudoangiomatous stromal hyperplasia. Breast J 2001;7(6):434-9.
  • 17. Powell CM, Cranor ML, Rosen PP. Pseudoangiomatous stromal hyperplasia (PASH). A mammary stromal tumor with myofibroblastic differentiation. Am J Surg Pathol 1995;19(3):270-7.
  • 18. Degnim AC, Frost MH, Radisky DC, Anderson SS, Vierkant RA, Boughey JC, Pankratz VS, Ghosh K, Hartmann LC, Visscher DW. Pseudoangiomatous stromal hyperplasia and breast cancer risk. Ann Surg Oncol 2010;17(12):3269-77.
  • 19. Ferreira M, Albarracin CT, Resetkova E. Pseudoangiomatous stromal hyperplasia tumor: a clinical, radiologic and pathologic study of 26 cases. Mod Pathol 2008;21(2):201-7.
There are 19 citations in total.

Details

Subjects Health Care Administration
Journal Section Case Reports
Authors

H. Utkan Aydın

Salih Onur Basat This is me

Burcu Çelet Özden This is me

Ufuk Emekli

Sıtkı Tuzlalı This is me

Publication Date June 30, 2017
Submission Date April 13, 2017
Published in Issue Year 2017 Volume: 80 Issue: 2

Cite

APA Aydın, H. U., Basat, S. O., Çelet Özden, B., Emekli, U., et al. (2017). PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW. Journal of Istanbul Faculty of Medicine, 80(2), 82-85. https://doi.org/10.18017/iuitfd.330078
AMA Aydın HU, Basat SO, Çelet Özden B, Emekli U, Tuzlalı S. PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW. İst Tıp Fak Derg. June 2017;80(2):82-85. doi:10.18017/iuitfd.330078
Chicago Aydın, H. Utkan, Salih Onur Basat, Burcu Çelet Özden, Ufuk Emekli, and Sıtkı Tuzlalı. “PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW”. Journal of Istanbul Faculty of Medicine 80, no. 2 (June 2017): 82-85. https://doi.org/10.18017/iuitfd.330078.
EndNote Aydın HU, Basat SO, Çelet Özden B, Emekli U, Tuzlalı S (June 1, 2017) PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW. Journal of Istanbul Faculty of Medicine 80 2 82–85.
IEEE H. U. Aydın, S. O. Basat, B. Çelet Özden, U. Emekli, and S. Tuzlalı, “PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW”, İst Tıp Fak Derg, vol. 80, no. 2, pp. 82–85, 2017, doi: 10.18017/iuitfd.330078.
ISNAD Aydın, H. Utkan et al. “PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW”. Journal of Istanbul Faculty of Medicine 80/2 (June 2017), 82-85. https://doi.org/10.18017/iuitfd.330078.
JAMA Aydın HU, Basat SO, Çelet Özden B, Emekli U, Tuzlalı S. PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW. İst Tıp Fak Derg. 2017;80:82–85.
MLA Aydın, H. Utkan et al. “PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW”. Journal of Istanbul Faculty of Medicine, vol. 80, no. 2, 2017, pp. 82-85, doi:10.18017/iuitfd.330078.
Vancouver Aydın HU, Basat SO, Çelet Özden B, Emekli U, Tuzlalı S. PSEUDOANGIOMATOUS STROMAL HYPERPLASIA (PASH) OF THE BREAST IN AN ADOLESCENT: A CASE REPORT AND LITERATURE REVIEW. İst Tıp Fak Derg. 2017;80(2):82-5.

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