Review
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Year 2020, Volume: 50 Issue: 3, 312 - 322, 30.12.2020

Abstract

References

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  • • Fortin, S., & Berube, G. (2013). Advances in the development of hybrid anticancer drugs. Expert Opinion on Drug Discovery, 8(8), 1029–1047. http://dx.doi.org/10.1517/17460441.2013.798296.
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  • • Gaspar, V. M., Costa, E. C., Queiroz, J. A., Pichon, C., & Sousa, F. (2015). Folate-targeted multifunctional amino acid-chitosan nanoparticles for improved cancer therapy. Pharmaceutical Research, 32(2), 562–577. http://dx.doi.org/10.1007/s11095-014-1486-0.
  • • Gibiansky, L., & Gibiansky, E. (2014). Target-mediated drug disposition model and its approximations for antibody–drug conjugates. Journal of Pharmacokinetics and Pharmacodynamics, 41(1), 35–47. http://dx.doi.org/10.1007/s10928-013-9344-y.
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  • • Guo, W., Deng, L., Chen, Z., Chen, Z., Yu, J., Liu, H. … Zhang, L. (2018). Vitamin B12-conjugated sericin micelles for targeting CD320-overexpressed gastric cancer and reversing drug resistance. Nanomedicine, 14(3), 353–370. https://doi.org/102217/ nnm-2018-0321.
  • • He, R., & Yin, C. (2017). Trimethyl chitosan based conjugate for oral and intravenous delivery of paclitaxel. Acta Biomaterial, 53, 355–366. http://dx.doi.org/10.1016/j.actbio.2017.02.012.
  • • Henne, W. A., Kularatne, S. A., Hakenjos, J., Carron, J. D., & Henne, K. L. (2013). Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate. Bioorganic & Medicinal Chemistry Letters, 23(21), 5810–5813. http://dx.doi.org/10.1016/j. bmcl.2013.08.113.
  • • Ibsen, S., Zahavy, E., Wrasdilo, W., Berns, M., & Chan, M. (2010). A novel doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy. Pharmaceutical Research, 27(9), 1848–1860. http://dx.doi.org/10.1007/s11095-010-0183-x.
  • • Iversen, T. G., Skotland, T., & Sandvig, K. (2011). Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano today, 6(2), 176–185. http://dx.doi. org/10.1016/j.nantod.2011.02.003.
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  • • Leamon, C. P., Vlahov I. R., Reddy, J. A., Vetzel, M., Santhapuram, H. K., You, F. … Westrick, E. (2014). Folate-vinca alkaloid conjugates for cancer therapy: A structure- activity relationship. Bioconjugate chemistry, 25(3), 560–568. http://dx.doi.org/10.1021/bc400441s.
  • • Leamon, C. P., Reddy, J. A., Vlahov, I. R., Westrick, E., Dawson, A., Dorton, R. … Wang, Y. (2007). Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Molecular Pharmaceutics, 4(5), 659–667. https://doi.org/10.1021/mp070049c.
  • • Mahato, R., Tai, W., & Cheng, K. (2011). Prodrugs for improving tumortargetability and efficiency. Advanced Drug Delivery Reviews, 63(8), 659–670. http://dx.doi.org/10.1016/j.addr.2011.02.002.
  • • Naumann, R.W., & Coleman, R. L. (2011). Management strategies for recurrent platinum-resistant ovarian cancer. Drugs, 71(11), 1397– 1412. http://dx.doi.org/10.2165/11591720-000000000-00000.
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Vitamin-anticancer drug conjugates: a new era for cancer therapy

Year 2020, Volume: 50 Issue: 3, 312 - 322, 30.12.2020

Abstract

Background: Following cardiovascular diseases, cancer is the world's second leading cause of death. Chemotherapy is the conventional gold technique for successful treatment of cancer. There are some drawbacks associated with traditional chemotherapy, namely, low aqueous solubility, limited biological half-life, production of multidrug resistance and non-specificity (lack of targeting ability) or dose-limiting cellular toxicity. To develop a targeted drug delivery for its anticancer effect is still a challenging task. Methods: We developed literature review methods which included inclusion and exclusion criteria for identifying potentially relevant articles, articles search strategies, abstract review protocols and a comprehensive scoring system for published studies. This study contains a detailed survey of various reported methods such as folic acid-drug conjugates, Cobalamin- Drug Conjugate, Vitamin B12-Conjugated and Paclitaxel-Loaded Micelles etc., all of which were studied for their methods of preparation and possible impact on biological activity. Results: Due to its specific ability to carry anticancer drugs directly to tumours, vitamin-mediated drug targeting has recently emerged as a novel concept. Solid tumour cancer has an unquenchable appetite for various essential vitamins, resulting in over-expression of the receptors involved in cell internalization of vitamins on the surface of cancer cells. So, the vitamin drug conjugates are specifically important for carrying the anticancer drugs directly to the tumour cells. Biotin, folic acid, vitamin B12 and riboflavin, the vitamin necessary for the division of all cells, especially cancer cells, have recently been examined as targeting agents. Conclusion: Vitamin-Drug Conjugate methods were found to be the most suitable methods amongst all the other reported methods and they can be applied for current therapy against cancer.

References

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  • • Bartouskova, M., Melichar, B., & Mohelnikova-Duchonova, B. (2015). Folate receptor: A potential target in ovarian cancer. Pteridines, 26(1), 1–2. https://doi.org/10.1515/pterid-2014-0013.
  • • Baskar, R., Lee, K. A., Yeo, R., & Yeoh, K. W. (2012). Cancer and radiation therapy: Current advances and future directions. International Journal of Medical Sciences, 9(3), 193. http://dx.doi.org/10.7150/ ijms.3635.
  • • Bildstein, L., Dubernet, C., & Couvreur, P. (2011). Prodrug-based intracellular delivery of anticancer agents. Advanced Drug Delivery Reviews, 63(1–2), 3–23.http://dx.doi.org/10.1016/j. addr.2010.12.005.
  • • Cavallaro, G., Maniscalco, L., Campisi, M., Schillaci, D., & Giammona, G. (2007). Synthesis, characterization and in vitro cytotoxicity studies of a macromolecular conjugate of paclitaxel bearing oxytocin as targeting moiety. European Journal of Pharmaceutics and Biopharmaceutics, 66(2), 182–192. http://dx.doi.org/10.1016/j. ejpb.2006.10.013.
  • • Chen, S., Zhao, X., Chen, J., Chen, J., Kuznetsova, L., Wong, S. S., & Ojima, I. (2010). Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release. Bioconjugate Chemistry, 21(5), 979–987. http://dx.doi.org/10.1021/bc9005656.
  • • Dai, Y., Cai, X., Bi, X., Liu, C., Yue, N., Zhu, Y. … Qian, H. (2019). Synthesis and anti-cancer evaluation of folic acid-peptide-paclitaxel conjugates for addressing drug resistance. European Journal of Medicinal Chemistry, 171,104–115. http://dx.doi.org/10.1016/j. ejmech.2019.03.031.
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  • • Florea, A. M., & Busselberg, D., (2011). Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects. Cancers, 3(1), 1351–1371. doi: 0.3390/cancers3011351
  • • Fortin, S., & Berube, G. (2013). Advances in the development of hybrid anticancer drugs. Expert Opinion on Drug Discovery, 8(8), 1029–1047. http://dx.doi.org/10.1517/17460441.2013.798296.
  • • Garraway, L. A., & Janne, P. A. (2012). Circumventing cancer drug resistance in the era of personalized medicine. Cancer Discovery, 2, 214–226. http://dx.doi.org/10.1158/2159-8290.CD-12-0012.
  • • Gaspar, V. M., Costa, E. C., Queiroz, J. A., Pichon, C., & Sousa, F. (2015). Folate-targeted multifunctional amino acid-chitosan nanoparticles for improved cancer therapy. Pharmaceutical Research, 32(2), 562–577. http://dx.doi.org/10.1007/s11095-014-1486-0.
  • • Gibiansky, L., & Gibiansky, E. (2014). Target-mediated drug disposition model and its approximations for antibody–drug conjugates. Journal of Pharmacokinetics and Pharmacodynamics, 41(1), 35–47. http://dx.doi.org/10.1007/s10928-013-9344-y.
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  • • Guo, W., Deng, L., Chen, Z., Chen, Z., Yu, J., Liu, H. … Zhang, L. (2018). Vitamin B12-conjugated sericin micelles for targeting CD320-overexpressed gastric cancer and reversing drug resistance. Nanomedicine, 14(3), 353–370. https://doi.org/102217/ nnm-2018-0321.
  • • He, R., & Yin, C. (2017). Trimethyl chitosan based conjugate for oral and intravenous delivery of paclitaxel. Acta Biomaterial, 53, 355–366. http://dx.doi.org/10.1016/j.actbio.2017.02.012.
  • • Henne, W. A., Kularatne, S. A., Hakenjos, J., Carron, J. D., & Henne, K. L. (2013). Synthesis and activity of a folate targeted monodisperse PEG camptothecin conjugate. Bioorganic & Medicinal Chemistry Letters, 23(21), 5810–5813. http://dx.doi.org/10.1016/j. bmcl.2013.08.113.
  • • Ibsen, S., Zahavy, E., Wrasdilo, W., Berns, M., & Chan, M. (2010). A novel doxorubicin prodrug with controllable photolysis activation for cancer chemotherapy. Pharmaceutical Research, 27(9), 1848–1860. http://dx.doi.org/10.1007/s11095-010-0183-x.
  • • Iversen, T. G., Skotland, T., & Sandvig, K. (2011). Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies. Nano today, 6(2), 176–185. http://dx.doi. org/10.1016/j.nantod.2011.02.003.
  • • Iwata, R., Nakayama, F., Hirochi, S., Sato, K., Piao, W., Nishina, K. … Wada, T. (2015). Synthesis and properties of vitamin E analogconjugated neomycin for delivery of RNAi drugs to liver cells. Bioorganic & Medicinal Chemistry Letters, 25(4),815–819. http://dx.doi. org/10.1016/j.bmcl.2014.12.079.
  • • Jung, J. H., & Keller, T. (2012). United States (12) Patent Application Publication (10) Pub. No.: US. 310126:A1. • Leamon, C. P. (2008) Folate-targeted drug strategies for the treatment of cancer. Current Opinion in Investigational Drugs, 9(12), 1277−1286.
  • • Leamon, C. P., Vlahov I. R., Reddy, J. A., Vetzel, M., Santhapuram, H. K., You, F. … Westrick, E. (2014). Folate-vinca alkaloid conjugates for cancer therapy: A structure- activity relationship. Bioconjugate chemistry, 25(3), 560–568. http://dx.doi.org/10.1021/bc400441s.
  • • Leamon, C. P., Reddy, J. A., Vlahov, I. R., Westrick, E., Dawson, A., Dorton, R. … Wang, Y. (2007). Preclinical antitumor activity of a novel folate-targeted dual drug conjugate. Molecular Pharmaceutics, 4(5), 659–667. https://doi.org/10.1021/mp070049c.
  • • Mahato, R., Tai, W., & Cheng, K. (2011). Prodrugs for improving tumortargetability and efficiency. Advanced Drug Delivery Reviews, 63(8), 659–670. http://dx.doi.org/10.1016/j.addr.2011.02.002.
  • • Naumann, R.W., & Coleman, R. L. (2011). Management strategies for recurrent platinum-resistant ovarian cancer. Drugs, 71(11), 1397– 1412. http://dx.doi.org/10.2165/11591720-000000000-00000.
  • • Naumann, R. W., Coleman, R. L., Burger, R. A., Sausville, E. A., Kutarska, E., Ghamande, S. A. … Gersh, R.H. (2013). PRECEDENT: A randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer. Journal of Clinical Oncology, 31(35), 4400–4406. http://dx.doi. org/10.1200/JCO.2013.49.7685.
  • • Ojima, I., Zuniga, E., Berger, W., & Seitz, J. (2012). Tumor-targeting drug delivery of new-generation taxoids. Future Medicinal Chemistry, 4(1), 33–50. http://dx.doi.org/10.4155/fmc.11.167.
  • • Padma, V. V. (2015). An overview of targeted cancer therapy. Bio- Medicine, 5(4). http://dx.doi.org/10.7603/s40681-015-0019-4.
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There are 58 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences, Health Care Administration
Journal Section Review
Authors

Ritesh P. Bhole This is me 0000-0003-4088-7470

Shradha Jadhav This is me 0000-0002-6443-5009

Yogesh B. Zambare This is me 0000-0001-5115-0971

Rupesh V. Chikhale This is me 0000-0001-5622-3981

Chandrakant G. Bonde This is me 0000-0001-5712-1119

Publication Date December 30, 2020
Submission Date January 13, 2020
Published in Issue Year 2020 Volume: 50 Issue: 3

Cite

APA Bhole, R. P., Jadhav, S., Zambare, Y. B., Chikhale, R. V., et al. (2020). Vitamin-anticancer drug conjugates: a new era for cancer therapy. İstanbul Journal of Pharmacy, 50(3), 312-322.
AMA Bhole RP, Jadhav S, Zambare YB, Chikhale RV, Bonde CG. Vitamin-anticancer drug conjugates: a new era for cancer therapy. iujp. December 2020;50(3):312-322.
Chicago Bhole, Ritesh P., Shradha Jadhav, Yogesh B. Zambare, Rupesh V. Chikhale, and Chandrakant G. Bonde. “Vitamin-Anticancer Drug Conjugates: A New Era for Cancer Therapy”. İstanbul Journal of Pharmacy 50, no. 3 (December 2020): 312-22.
EndNote Bhole RP, Jadhav S, Zambare YB, Chikhale RV, Bonde CG (December 1, 2020) Vitamin-anticancer drug conjugates: a new era for cancer therapy. İstanbul Journal of Pharmacy 50 3 312–322.
IEEE R. P. Bhole, S. Jadhav, Y. B. Zambare, R. V. Chikhale, and C. G. Bonde, “Vitamin-anticancer drug conjugates: a new era for cancer therapy”, iujp, vol. 50, no. 3, pp. 312–322, 2020.
ISNAD Bhole, Ritesh P. et al. “Vitamin-Anticancer Drug Conjugates: A New Era for Cancer Therapy”. İstanbul Journal of Pharmacy 50/3 (December 2020), 312-322.
JAMA Bhole RP, Jadhav S, Zambare YB, Chikhale RV, Bonde CG. Vitamin-anticancer drug conjugates: a new era for cancer therapy. iujp. 2020;50:312–322.
MLA Bhole, Ritesh P. et al. “Vitamin-Anticancer Drug Conjugates: A New Era for Cancer Therapy”. İstanbul Journal of Pharmacy, vol. 50, no. 3, 2020, pp. 312-2.
Vancouver Bhole RP, Jadhav S, Zambare YB, Chikhale RV, Bonde CG. Vitamin-anticancer drug conjugates: a new era for cancer therapy. iujp. 2020;50(3):312-2.