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The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery

Year 2022, Volume: 1 Issue: 3, 128 - 135, 19.12.2022
https://doi.org/10.57221/izmirtip.1167088

Abstract

Aim: The purpose of this study was comparing the type of anesthesia in geriatric patients undergoing orthopedic surgery with cerebral tissue oxygen saturation values and Mini Mental Test (MMT) scores. The relationship between cerebral tissue oxygen saturation values and MMT scores was also evaluated. Material and methods: A total of 40 patients over the age of 65 and above who were scheduled for Proximal Femoral Nail Antirotation (PFN-A) operation were included in our study. Cases were divided into 2 groups as general anesthesia (Group I) and spinal anesthesia (Group II). Cerebral tissue oxygen saturation right and left values and hemodynamic data were measured at regular intervals in the preoperative period until the postoperative 48th hour. MMT scores at the preoperative and 48th postoperative hours were evaluated. The relationship between cerebral oxygen saturation values and MMT scores were evaluated. Results: Although there was decreased in the MMT scores performed at 48th postoperative hours compared with the preoperative period, no statistically significant difference was observed between the groups (p>0.05). When the cerebral tissue oxygen saturation right and left values in the perioperative period were compared, there was no statistically significant difference between the groups, although there was a decrease in the cerebral tissue oxygen saturation values (p>0.05). When the relationship between perioperative cerebral tissue oxygen saturation right and left values and the MMT scores were examined, no statistically significant relationship was found (CI%95:0.318-35.364) (p>0.05). Conclusion: In elderly patients who undergo minimally invasive orthopedic surgery, a decrease in cerebral tissue oxygen saturation values and MMT scores can be seen in the perioperative period in both spinal anesthesia and general anesthesia. However, there was no relationship between cerebral tissue oxygen saturation values and MMT scores. 

Thanks

The authors thank Associate Professor Timur Kose and Research Assistant Semiha Ozgul (Department of Biostatistical, Ege University, Medical Faculty, Izmir, Turkey) for statistical analysis.

References

  • 1.Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS, postoperative cognitive dysfunction (POCD) group. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110:548-55.
  • 2.Kotekar N, Shenkar A, Nagaraj R. Postoperative cognitive dysfunction – current preventive strategies. Clin Interv Aging. 2018;13:2267-73. 3.Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand.2003;47:260-6. 4.Fitzpatrick S, Owen K. Postoperative cognitive disorders : postoperative delirium and postoperative cognitive dysfunction. Anaesth Tutor Week. 2018;152:1-6.
  • 5.Chaudhari AP, Mazumdar K, Mehta PD. Anxiety, depression, and quality of life in women with polycystic ovarian syndrome. 2018;40:239-46.
  • 6.Figuls RM, Cosp BX, Arevalo-Rodriguez CS. Cochrane database of systematic reviews mini-mental state examination (MMSE) for the detection of Alzheimer’s disease and other dementias in people with mild cognitive impairment (MCI). 2015;5;2015:CD010783.
  • 7.Güngen C, Ertan T, Eker E, Yaşar R, Engi̇n F. Mini Mental Test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 2002;13:273-81.
  • 8.Myrberg K, Hydén LC, Samuelsson C. The mini-mental state examination (MMSE) from a language perspective: an analysis of test interaction. 2020;34:652-70.
  • 9.Owczuk R. Guidelines for general anaesthesia in the elderly of the Committee on Quality and Safety in Anaesthesia, Polish Society of Anaesthesiology and Intensive Therapy. Anaesthesiol Intensive Ther. 2013;45:57-61.
  • 10.Elwell CE, Cooper CE. Making light work: Illuminating the future of biomedical optics. Philos Trans R Soc A Math Phys Eng Sci. 2011;369(1955):4358-79.
  • 11.Ito H, Kanno I, Iida H, Hatazawa J, Shimosegawa E, Tamura H et al. Arterial fraction of cerebral blood volume in humans measured by positron emission tomography. Ann Nucl Med. 2001;15:111-6.
  • 12.Grubhofer G, Plöchl W, Skolka M, Czerny M, Ehrlich M, Lassnigg A. Comparing Doppler ultrasonography and cerebral oximetry as indicators for shunting in carotid endarterectomy. Anesth Analg. 2000;91:1339-44. 13.Tang L, Kazan R, Taddei R, Zaouter C, Cyr S, Hemmerling TM. Reduced cerebral oxygen saturation during thoracic surgery predicts early Postoperative cognitive dysfunction. Br J Anaesth. 2012;108:623-9.
  • 14.Çelik EC, Çiftçi B. Cerebral oximetry and applications under anesthesia. İstanbul Tıp Fakültesi Derg. 2018;8:33-6.
  • 15.Slater JP, Guarino T, Stack J, Vinod K, Bustami RT, Brown JM 3rd et al. Cerebral oxygen desaturation predicts cognitive decline and longer hospital stay after cardiac surgery. Ann Thorac Surg. 2009;87:36-45. 16.Hoppenstein D, Zohar E, Ramaty E, Shabat S, Fredman B. The effects of general vs spinal anesthesia on frontal cerebral oxygen saturation in geriatric patients undergoing emergency surgical fixation of the neck of femur. J Clin Anesth. 2005;17:431-8. 17.Mandal S, Basu M, Kirtania J, Sarbapalli D, Pal R, Kar S et al. Impact of general versus epidural anesthesia on early post-operative cognitive dysfunction following hip and knee surgery. J Emergencies, Trauma Shock. 2011;4:23-8.
  • 18.Shi HJ, Xue XH, Wang YL, Zhang WS, Wang ZS, Yu AL. Effects of different anesthesia methods on cognitive dysfunction after hip replacement operationin elder patients. Int J Clin Exp Med. 2015;8:3883-8.
  • 19.Papadopoulos G, Karanikolas M, Liarmakopoulou A, Papathanakos G, Korre M, Beris A. Cerebral oximetry and cognitive dysfunction in elderly patients undergoing surgery for hip fractures: a prospective observational study. Open Orthop J. 2012;6:400-5.
  • 20.Kim J, Shim JK, Song JW, Kim EK, Kwak YL. Postoperative cognitive dysfunction and the change of regional cerebral oxygen saturation in elderly patients undergoing spinal surgery. Anesth Analg. 2016;123:436-44.
  • 21.Colak Z, Borojevic M, Bogovic A, Ivancan V, Biocina B. In fl uence of intraoperative cerebral oximetry monitoring on neurocognitive function after coronary artery bypass surgery : a randomized, prospective study. 2015;47:447-54.

Ortopedik Cerrahi Geçiren Geriatrik Hastalarda Postoperatif Kognitif Disfonksiyon ve Serebral Oksimetri Korelasyonu

Year 2022, Volume: 1 Issue: 3, 128 - 135, 19.12.2022
https://doi.org/10.57221/izmirtip.1167088

Abstract

Amaç: Bu çalışmada birincil amacımız, ortopedik cerrahi uygulanan geriatrik hastalarda anestezi tipinin serebral oksijen satürasyonu değerleri ve Mini Mental Test (MMT) skorları ile karşılaştırılmasıdır. Bu çalışmadaki ikincil amacımız, serebral oksijen satürasyon değerleri ile MMT puanları arasındaki ilişkiyi değerlendirmekti. Gereç ve Yöntemler: Çalışmamıza Proksimal Femoral Çivi Antirotasyon (PFN-A) operasyonu planlanan 65 yaş üstü toplam 40 hasta dahil edildi. Olgular Genel Anestezi ve Spinal Anestezi olarak 2 gruba ayrıldı. Preoperatif dönemde postoperatif 48. saate kadar düzenli aralıklarla serebral doku oksijen satürasyonu sağ ve sol değerleri ve hemodinamik veriler ölçüldü. Ameliyat öncesi ve ameliyat sonrası 48. saatteki MMT skorları değerlendirildi. Tüm veriler grup I ve grup II arasında karşılaştırıldı. Serebral oksijen satürasyon değerleri ile MMT skorları arasındaki ilişki değerlendirildi. Bulgular: Ameliyat sonrası 48. saatte yapılan MMT skorlarında ameliyat öncesi döneme göre azalma olmasına rağmen, gruplar arasında istatistiksel olarak anlamlı fark gözlenmedi (p>0,05). Perioperatif dönemde serebral oksijen satürasyonu sağ ve sol değerleri karşılaştırıldığında, serebral oksijen satürasyonu değerlerinde azalma olmasına rağmen gruplar arasında istatistiksel olarak anlamlı fark yoktu(p>0,05). Perioperatif serebral oksijen satürasyonu sağ ve sol değerleri ile MMT skorları arasındaki ilişki incelendiğinde istatistiksel olarak anlamlı bir ilişki bulunamadı (CI% 95:0,318-35,364) (p>0,05). Sonuç: Minimal invaziv ortopedik cerrahi uygulanan geriatrik hastalarda hem spinal anestezide hem de genel anestezide perioperatif dönemde serebral doku oksijen satürasyon değerlerinde ve MMT skorlarında azalma görülebilmektedir. Ancak serebral doku oksijen satürasyon değerleri ile MMT skorları arasında ilişki yoktu. Bu konuda daha kapsamlı çalışmalara ihtiyaç vardır.

References

  • 1.Steinmetz J, Christensen KB, Lund T, Lohse N, Rasmussen LS, postoperative cognitive dysfunction (POCD) group. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110:548-55.
  • 2.Kotekar N, Shenkar A, Nagaraj R. Postoperative cognitive dysfunction – current preventive strategies. Clin Interv Aging. 2018;13:2267-73. 3.Rasmussen LS, Johnson T, Kuipers HM, Kristensen D, Siersma VD, Vila P et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand.2003;47:260-6. 4.Fitzpatrick S, Owen K. Postoperative cognitive disorders : postoperative delirium and postoperative cognitive dysfunction. Anaesth Tutor Week. 2018;152:1-6.
  • 5.Chaudhari AP, Mazumdar K, Mehta PD. Anxiety, depression, and quality of life in women with polycystic ovarian syndrome. 2018;40:239-46.
  • 6.Figuls RM, Cosp BX, Arevalo-Rodriguez CS. Cochrane database of systematic reviews mini-mental state examination (MMSE) for the detection of Alzheimer’s disease and other dementias in people with mild cognitive impairment (MCI). 2015;5;2015:CD010783.
  • 7.Güngen C, Ertan T, Eker E, Yaşar R, Engi̇n F. Mini Mental Test’in Türk toplumunda hafif demans tanısında geçerlik ve güvenilirliği. Türk Psikiyatri Dergisi 2002;13:273-81.
  • 8.Myrberg K, Hydén LC, Samuelsson C. The mini-mental state examination (MMSE) from a language perspective: an analysis of test interaction. 2020;34:652-70.
  • 9.Owczuk R. Guidelines for general anaesthesia in the elderly of the Committee on Quality and Safety in Anaesthesia, Polish Society of Anaesthesiology and Intensive Therapy. Anaesthesiol Intensive Ther. 2013;45:57-61.
  • 10.Elwell CE, Cooper CE. Making light work: Illuminating the future of biomedical optics. Philos Trans R Soc A Math Phys Eng Sci. 2011;369(1955):4358-79.
  • 11.Ito H, Kanno I, Iida H, Hatazawa J, Shimosegawa E, Tamura H et al. Arterial fraction of cerebral blood volume in humans measured by positron emission tomography. Ann Nucl Med. 2001;15:111-6.
  • 12.Grubhofer G, Plöchl W, Skolka M, Czerny M, Ehrlich M, Lassnigg A. Comparing Doppler ultrasonography and cerebral oximetry as indicators for shunting in carotid endarterectomy. Anesth Analg. 2000;91:1339-44. 13.Tang L, Kazan R, Taddei R, Zaouter C, Cyr S, Hemmerling TM. Reduced cerebral oxygen saturation during thoracic surgery predicts early Postoperative cognitive dysfunction. Br J Anaesth. 2012;108:623-9.
  • 14.Çelik EC, Çiftçi B. Cerebral oximetry and applications under anesthesia. İstanbul Tıp Fakültesi Derg. 2018;8:33-6.
  • 15.Slater JP, Guarino T, Stack J, Vinod K, Bustami RT, Brown JM 3rd et al. Cerebral oxygen desaturation predicts cognitive decline and longer hospital stay after cardiac surgery. Ann Thorac Surg. 2009;87:36-45. 16.Hoppenstein D, Zohar E, Ramaty E, Shabat S, Fredman B. The effects of general vs spinal anesthesia on frontal cerebral oxygen saturation in geriatric patients undergoing emergency surgical fixation of the neck of femur. J Clin Anesth. 2005;17:431-8. 17.Mandal S, Basu M, Kirtania J, Sarbapalli D, Pal R, Kar S et al. Impact of general versus epidural anesthesia on early post-operative cognitive dysfunction following hip and knee surgery. J Emergencies, Trauma Shock. 2011;4:23-8.
  • 18.Shi HJ, Xue XH, Wang YL, Zhang WS, Wang ZS, Yu AL. Effects of different anesthesia methods on cognitive dysfunction after hip replacement operationin elder patients. Int J Clin Exp Med. 2015;8:3883-8.
  • 19.Papadopoulos G, Karanikolas M, Liarmakopoulou A, Papathanakos G, Korre M, Beris A. Cerebral oximetry and cognitive dysfunction in elderly patients undergoing surgery for hip fractures: a prospective observational study. Open Orthop J. 2012;6:400-5.
  • 20.Kim J, Shim JK, Song JW, Kim EK, Kwak YL. Postoperative cognitive dysfunction and the change of regional cerebral oxygen saturation in elderly patients undergoing spinal surgery. Anesth Analg. 2016;123:436-44.
  • 21.Colak Z, Borojevic M, Bogovic A, Ivancan V, Biocina B. In fl uence of intraoperative cerebral oximetry monitoring on neurocognitive function after coronary artery bypass surgery : a randomized, prospective study. 2015;47:447-54.
There are 16 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Articles
Authors

Fatih Mehmet Kurt 0000-0003-4953-1745

Gaye Aydın 0000-0003-1441-9462

Publication Date December 19, 2022
Submission Date August 30, 2022
Published in Issue Year 2022 Volume: 1 Issue: 3

Cite

APA Kurt, F. M., & Aydın, G. (2022). The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery. İzmir Tıp Fakültesi Dergisi, 1(3), 128-135. https://doi.org/10.57221/izmirtip.1167088
AMA Kurt FM, Aydın G. The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery. İzmir Tıp Fak. Derg. December 2022;1(3):128-135. doi:10.57221/izmirtip.1167088
Chicago Kurt, Fatih Mehmet, and Gaye Aydın. “The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery”. İzmir Tıp Fakültesi Dergisi 1, no. 3 (December 2022): 128-35. https://doi.org/10.57221/izmirtip.1167088.
EndNote Kurt FM, Aydın G (December 1, 2022) The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery. İzmir Tıp Fakültesi Dergisi 1 3 128–135.
IEEE F. M. Kurt and G. Aydın, “The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery”, İzmir Tıp Fak. Derg., vol. 1, no. 3, pp. 128–135, 2022, doi: 10.57221/izmirtip.1167088.
ISNAD Kurt, Fatih Mehmet - Aydın, Gaye. “The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery”. İzmir Tıp Fakültesi Dergisi 1/3 (December 2022), 128-135. https://doi.org/10.57221/izmirtip.1167088.
JAMA Kurt FM, Aydın G. The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery. İzmir Tıp Fak. Derg. 2022;1:128–135.
MLA Kurt, Fatih Mehmet and Gaye Aydın. “The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery”. İzmir Tıp Fakültesi Dergisi, vol. 1, no. 3, 2022, pp. 128-35, doi:10.57221/izmirtip.1167088.
Vancouver Kurt FM, Aydın G. The Correlation of Postoperative Cognitive Dysfunction and Cerebral Oximetry in Geriatric Patients Undergoing Orthopedic Surgery. İzmir Tıp Fak. Derg. 2022;1(3):128-35.