Helicobakter Pylori'nin Gastrik Karsinogenezde Etkili Virülans Faktörlerinin Değerlendirilmesi: Sistematik Derleme

Year 2023, Volume: 2 Issue: 4, 226 - 233, 25.12.2023

Yüksel Yaşın , Gulden Diniz , Şevval Evcimen , Emine Müge Karakayalı

https://doi.org/10.57221/izmirtip.1264415

Abstract

Bu çalışmada, Helicobacter pylori’nin gastrik kanser gelişiminde etkili olduğu düşünülen virülans faktörlerini araştıran çalışmaların sistematik olarak değerlendirmesi amaçlanmıştır. Bu sistematik derleme kapsamında incelenen 14 çalışma, Helicobacter pylori’nin virülans faktörleri arasındaki sitotoksin ilişkili gen A (CagA), vakuolatör sitotoksin A (VacA), dış inflamatuar proteinler, siyalik asit bağlayıcı adezin (SabA), DNA metilasyonu, üreaz, the induced by contact with epithelium gene, interlökin-8 ve E-cadherin’in mide karsinogenezi üzerine olan etkilerini irdelemektedir. Literatürde gastrik karsinogenezde önemli rol oynadığı öne sürülen tüm bu virülans faktörlerini birlikte irdeleyen bir çalışma yoktur. Bu sistematik derlemede CagA, VacA, OipA, SabA ve üreazın H. pylori'nin mide karsinogenezinde en etkili virülans faktörleri olduğu belirlenmiştir.

Keywords

Helicobacter pylori virülans faktörleri, Gastrik karsinogenez, Virülans faktörleri

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