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Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus

Year 2009, Volume: 3 Issue: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

https://izlik.org/JA97LG68TW

Abstract

It is generally believed that viral clearance or chronic infection following hepatitis B virus (HBV) infection is linked to the genetic background of the host and human leukocyte antigens (HLA) play a central role. This study was conducted to determine associations between some of HLA classI genes with the outcome of hepatitis B infection. Subjects of this study were 64 individuals who were assigned into two group, case and con trol, based on their clinical and ser ologic profiles. Case gr oup were 27 p atients infected with HBV and controls were 37 subjects with HBV natural convalescent who recovered from a HBV in fection. Ty ping of HLA cla ss I was performed b y serol ogic method. No significant difference was f ound between mean age of co ntrol and patie nt group while th e differ ence in sex of two groups was significant (P<0.05). The most fr equent detected HLA antigens were B51 (40, 1%), B27 (14 .1%), B8 (12 .5%) and B7 (10.9%). Significant association was found between HBV p ersistence and HLA-B27. HLA-B 27 was associated with an increase in HB Vpersistence. The findings su pport the id ea that polymorphism of HLA class I may influence th e chronicity of HBV infection

Keywords

HLA Hepatitis B HBV persistence

Year 2009, Volume: 3 Issue: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

https://izlik.org/JA97LG68TW

Abstract

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Details

Other ID JA59DY53DM
Authors

Mohammad Najafızadeh This is me

Naser Farhadı This is me

Bahador Sarkarı This is me

Publication Date July 1, 2009
IZ https://izlik.org/JA97LG68TW
Published in Issue Year 2009 Volume: 3 Issue: 2

Cite

APA Najafızadeh, M., Farhadı, N., & Sarkarı, B. (2009). Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences, 3(2), 59-61. https://izlik.org/JA97LG68TW
AMA 1.Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3(2):59-61. https://izlik.org/JA97LG68TW
Chicago Najafızadeh, Mohammad, Naser Farhadı, and Bahador Sarkarı. 2009. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3 (2): 59-61. https://izlik.org/JA97LG68TW.
EndNote Najafızadeh M, Farhadı N, Sarkarı B (July 1, 2009) Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences 3 2 59–61.
IEEE [1]M. Najafızadeh, N. Farhadı, and B. Sarkarı, “Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus”, J.appl.biol.sci., vol. 3, no. 2, pp. 59–61, July 2009, [Online]. Available: https://izlik.org/JA97LG68TW
ISNAD Najafızadeh, Mohammad - Farhadı, Naser - Sarkarı, Bahador. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3/2 (July 1, 2009): 59-61. https://izlik.org/JA97LG68TW.
JAMA 1.Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3:59–61.
MLA Najafızadeh, Mohammad, et al. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences, vol. 3, no. 2, July 2009, pp. 59-61, https://izlik.org/JA97LG68TW.
Vancouver 1.Mohammad Najafızadeh, Naser Farhadı, Bahador Sarkarı. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. [Internet]. 2009 Jul. 1;3(2):59-61. Available from: https://izlik.org/JA97LG68TW