The Evaluation of The Oxidative Stres Parameters in Cases With Hypo -or Hyper- Thyroidism

Abstract

We have investigated the oxidative stress and antioxidant capacity differences in cases with hyper- or hypo-thyroidism. We have evaluated Malonyldialdehyde (MDA) stages as an evidence of lipid peroxidation, protein carbonyl stages as a screen of protein oxidation and protein sulfydryl (SH) groups stages as a screen of antioxidant capacity in a group of 50 cases (clinically hyperthyroid, 12; subclinically hyperthyroid, 13; clinically hypothyroid, 10; and subclinically hypothyroid, 15).In comparison to the control group, MDA levels of hypothyroid and subclinic hyperthyroid groups were found to be significantly higher, and protein carbonyl levels in subclinically hypothyroid patients were significantly higher and SH group levels in subclinically hypothyroid, clinically hyperthyroid and subclinically hyperthyroid groups were lower.We have demonstrated that hyperthyroidism and hypothyroidism might lead to an increase in free radicals and might also cause a difference in the antioxidant defence system

Keywords

• Hyperthyroidism, hypothyroidism, oxidative stress