Investigation of the Protective Effect of Sığla Oil Against Carbon Tetrachloride- Induced Toxication in Kidney

Abstract

Objective: In this study, the intention was to investigate the relation between carbon tetrachloride (CCl4)-induced renal damage and malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and nitric oxide (NO) enzyme activities; as well as the effect of sığla oil (storax, also commonly known as Turkish sweetgum) on the metabolism. Materials and Methods: Rats were randomly divided into 5 groups as control (n=10), CCl4 (n=10), CCl4+sığla oil (50 mg/kg) (n=10), CCl4+ sığla oil (100 mg/kg) (n=10), and CCl+ sığla oil (200 mg/kg) (n=10). Results: In the group administered carbon tetrachloride, the CAT, GPx and GSH levels were observed to be decreased and MDA and NO levels were increased. In the treatment group (CCl4+sığla oil), the MDA and NO levels decreased and the CAT, GPx and GSH levels increased close to that of the control group. Conclusion: In this study, where the effect of sığla oil on CCl-induced renal oxidative damage was investigated, it was observed that the sığla oil reinforced the antioxidant system by suppressing the oxidative stress, and that the results obtained with the increased doses, in particular, were most effective

Keywords

• Carbon tetrachloride, kidney damage, sığla oil (Turkish sweetgum), antioxidant