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Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus

Year 2009, Volume: 3 Issue: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

Abstract

It is generally believed that viral clearance or chronic infection following hepatitis B virus (HBV) infection is linked to the genetic background of the host and human leukocyte antigens (HLA) play a central role. This study was conducted to determine associations between some of HLA classI genes with the outcome of hepatitis B infection. Subjects of this study were 64 individuals who were assigned into two group, case and con trol, based on their clinical and ser ologic profiles. Case gr oup were 27 p atients infected with HBV and controls were 37 subjects with HBV natural convalescent who recovered from a HBV in fection. Ty ping of HLA cla ss I was performed b y serol ogic method. No significant difference was f ound between mean age of co ntrol and patie nt group while th e differ ence in sex of two groups was significant (P<0.05). The most fr equent detected HLA antigens were B51 (40, 1%), B27 (14 .1%), B8 (12 .5%) and B7 (10.9%). Significant association was found between HBV p ersistence and HLA-B27. HLA-B 27 was associated with an increase in HB Vpersistence. The findings su pport the id ea that polymorphism of HLA class I may influence th e chronicity of HBV infection

Keywords

HLA Hepatitis B HBV persistence

Year 2009, Volume: 3 Issue: 2, 59 - 61, 01.07.2009

Mohammad Najafızadeh Naser Farhadı Bahador Sarkarı

Abstract

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Details

Other ID JA59DY53DM
Journal Section Research Article
Authors

Mohammad Najafızadeh This is me

Naser Farhadı This is me

Bahador Sarkarı This is me

Publication Date July 1, 2009
Published in Issue Year 2009 Volume: 3 Issue: 2

Cite

APA Najafızadeh, M., Farhadı, N., & Sarkarı, B. (2009). Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences, 3(2), 59-61.
AMA Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. July 2009;3(2):59-61.
Chicago Najafızadeh, Mohammad, Naser Farhadı, and Bahador Sarkarı. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3, no. 2 (July 2009): 59-61.
EndNote Najafızadeh M, Farhadı N, Sarkarı B (July 1, 2009) Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. Journal of Applied Biological Sciences 3 2 59–61.
IEEE M. Najafızadeh, N. Farhadı, and B. Sarkarı, “Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus”, J.appl.biol.sci., vol. 3, no. 2, pp. 59–61, 2009.
ISNAD Najafızadeh, Mohammad et al. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences 3/2 (July 2009), 59-61.
JAMA Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3:59–61.
MLA Najafızadeh, Mohammad et al. “Association of HLA- B7, B8, B27 and B51 With Genetic Protection Against Hepatitis B Virus”. Journal of Applied Biological Sciences, vol. 3, no. 2, 2009, pp. 59-61.
Vancouver Najafızadeh M, Farhadı N, Sarkarı B. Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus. J.appl.biol.sci. 2009;3(2):59-61.